FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4307906303> ?p ?o ?g. }

• W4307906303 endingPage "105456" @default.
• W4307906303 startingPage "105456" @default.
• W4307906303 abstract "BK polyomavirus-associated nephropathy is one of serious complications in transplant recipients. Everolimus–a mammalian target of rapamycin inhibitor–has been shown to reduce the incidence of BK polyomavirus infection in transplant recipients. In this study, the effects of everolimus were examined on viral replication and the spread of infection in BK polyomavirus-infected cultures. BK polyomavirus replicated in renal and pulmonary cells, contrary to that in hepatocytes, and spread as diffusely scattered patterns of infected cells, unlike plaque formation through the cell-to-cell mode. BK polyomavirus is stable to heat up to 65 °C with a particle per infectivity ratio of 5000, and the replication cycle was for approximately 34 h. Everolimus administration remarkably reduced the viral replication to 20% in cells treated with 0.1–10 ng/mL, the concentration at which everolimus reached the serum of transplant recipients. In addition, it reduced the amount of viral capsid protein 1 at 5 ng/mL without reducing the ratio of viral capsid protein 1 versus β-actin, and it also retained the pattern of viral capsid protein 1 localization in the nuclei. Everolimus suppressed the number of infected cells to 32.8% during a 14-day treatment, indicating the reduction of BK polyomavirus-infected cell mass to 18.8% of untreated cultures by modifying cellular functions. The reduction in the total number of BK polyomavirus infected cells by everolimus indicates that everolimus alleviates BK polyomavirus infection, including nephropathy in transplant recipients." @default.
• W4307906303 created "2022-11-06" @default.
• W4307906303 creator A5007613905 @default.
• W4307906303 creator A5016274180 @default.
• W4307906303 creator A5031231986 @default.
• W4307906303 creator A5039217080 @default.
• W4307906303 creator A5040004569 @default.
• W4307906303 creator A5046211758 @default.
• W4307906303 creator A5050145930 @default.
• W4307906303 creator A5078077911 @default.
• W4307906303 creator A5079193296 @default.
• W4307906303 date "2022-12-01" @default.
• W4307906303 modified "2023-10-10" @default.
• W4307906303 title "Everolimus reduces BK polyomavirus infection by suppressing its replication and spread of infection" @default.
• W4307906303 cites W1600996638 @default.
• W4307906303 cites W1994524871 @default.
• W4307906303 cites W2004122096 @default.
• W4307906303 cites W2010330416 @default.
• W4307906303 cites W2027232309 @default.
• W4307906303 cites W2034567308 @default.
• W4307906303 cites W2054311780 @default.
• W4307906303 cites W2084411902 @default.
• W4307906303 cites W2088168913 @default.
• W4307906303 cites W2099073545 @default.
• W4307906303 cites W2099540110 @default.
• W4307906303 cites W2112595386 @default.
• W4307906303 cites W2130566278 @default.
• W4307906303 cites W2136464549 @default.
• W4307906303 cites W2142207981 @default.
• W4307906303 cites W2153066661 @default.
• W4307906303 cites W2191953148 @default.
• W4307906303 cites W2232708494 @default.
• W4307906303 cites W2584555419 @default.
• W4307906303 cites W2584967320 @default.
• W4307906303 cites W2623181425 @default.
• W4307906303 cites W2778181590 @default.
• W4307906303 cites W2799859234 @default.
• W4307906303 cites W2904812958 @default.
• W4307906303 cites W2913695173 @default.
• W4307906303 cites W2916803262 @default.
• W4307906303 cites W2919855672 @default.
• W4307906303 cites W2940714457 @default.
• W4307906303 cites W2948396358 @default.
• W4307906303 cites W3005590930 @default.
• W4307906303 cites W3023097846 @default.
• W4307906303 cites W3034833465 @default.
• W4307906303 doi "https://doi.org/10.1016/j.antiviral.2022.105456" @default.
• W4307906303 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36328070" @default.
• W4307906303 hasPublicationYear "2022" @default.
• W4307906303 type Work @default.
• W4307906303 citedByCount "1" @default.
• W4307906303 countsByYear W43079063032023 @default.
• W4307906303 crossrefType "journal-article" @default.
• W4307906303 hasAuthorship W4307906303A5007613905 @default.
• W4307906303 hasAuthorship W4307906303A5016274180 @default.
• W4307906303 hasAuthorship W4307906303A5031231986 @default.
• W4307906303 hasAuthorship W4307906303A5039217080 @default.
• W4307906303 hasAuthorship W4307906303A5040004569 @default.
• W4307906303 hasAuthorship W4307906303A5046211758 @default.
• W4307906303 hasAuthorship W4307906303A5050145930 @default.
• W4307906303 hasAuthorship W4307906303A5078077911 @default.
• W4307906303 hasAuthorship W4307906303A5079193296 @default.
• W4307906303 hasConcept C106358424 @default.
• W4307906303 hasConcept C134018914 @default.
• W4307906303 hasConcept C140704245 @default.
• W4307906303 hasConcept C142462285 @default.
• W4307906303 hasConcept C159047783 @default.
• W4307906303 hasConcept C202878990 @default.
• W4307906303 hasConcept C2522874641 @default.
• W4307906303 hasConcept C2778199330 @default.
• W4307906303 hasConcept C2779699572 @default.
• W4307906303 hasConcept C2780091579 @default.
• W4307906303 hasConcept C2780303639 @default.
• W4307906303 hasConcept C2909782663 @default.
• W4307906303 hasConcept C54355233 @default.
• W4307906303 hasConcept C86803240 @default.
• W4307906303 hasConceptScore W4307906303C106358424 @default.
• W4307906303 hasConceptScore W4307906303C134018914 @default.
• W4307906303 hasConceptScore W4307906303C140704245 @default.
• W4307906303 hasConceptScore W4307906303C142462285 @default.
• W4307906303 hasConceptScore W4307906303C159047783 @default.
• W4307906303 hasConceptScore W4307906303C202878990 @default.
• W4307906303 hasConceptScore W4307906303C2522874641 @default.
• W4307906303 hasConceptScore W4307906303C2778199330 @default.
• W4307906303 hasConceptScore W4307906303C2779699572 @default.
• W4307906303 hasConceptScore W4307906303C2780091579 @default.
• W4307906303 hasConceptScore W4307906303C2780303639 @default.
• W4307906303 hasConceptScore W4307906303C2909782663 @default.
• W4307906303 hasConceptScore W4307906303C54355233 @default.
• W4307906303 hasConceptScore W4307906303C86803240 @default.
• W4307906303 hasFunder F4320334764 @default.
• W4307906303 hasLocation W43079063031 @default.
• W4307906303 hasLocation W43079063032 @default.
• W4307906303 hasOpenAccess W4307906303 @default.
• W4307906303 hasPrimaryLocation W43079063031 @default.
• W4307906303 hasRelatedWork W2035043466 @default.
• W4307906303 hasRelatedWork W2205973852 @default.
• W4307906303 hasRelatedWork W2327414686 @default.

• next