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• W4307908369 abstract "Seasonal malaria chemoprevention is an important intervention recommended for children aged 3–59 months living in highly seasonal transmission areas of the Sahel subregion of Africa to provide protection against malaria during the rainy season. 1 WHOWHO policy recommendation: seasonal malaria chemoprevention (SMC) for Plasmodium falciparum malaria control in highly seasonal transmission areas of the Sahel sub-region in Africa. https://apps.who.int/iris/handle/10665/337978Date: 2012 Date accessed: September 12, 2022 Google Scholar In The Lancet Infectious Diseases, Colin J Sutherland and colleagues 2 Beshir KB Muwanguzi J Nader J et al. Prevalence of Plasmodium falciparum haplotypes associated with resistance to sulfadoxine–pyrimethamine and amodiaquine before and after upscaling of seasonal malaria chemoprevention in seven African countries: a genomics surveillance study. Lancet Infect Dis. 2022; (published online Oct 31.)https://doi.org/10.1016/S1473-3099(22)00593-X Summary Full Text Full Text PDF PubMed Scopus (4) Google Scholar report on the prevalence of Plasmodium falciparum genetic variants associated with drug resistance before and after the implementation of seasonal malaria chemoprevention with sulfadoxine–pyrimethamine plus amodiaquine in areas across seven Sahelian countries (Burkina Faso, Chad, Guinea, Mali, Nigeria, Niger, and The Gambia). In these areas, monthly seasonal malaria chemoprevention was scaled up among children younger than 5 years in 2016, and community surveys including a collection of dried blood spot samples were conducted at baseline from December, 2015, to March, 2016, and two years later, from December, 2017, to March, 2018 (periods theoretically following the malaria transmission seasons in the study areas). In parallel, individuals aged 10–30 years not receiving seasonal malaria chemoprevention drugs were surveyed as a control population. Infections with P falciparum parasites were monitored, with attention paid to isolates harbouring specific molecular markers to sulfadoxine–pyrimethamine (ie, alleles in the dhfr and dhps genes) and to amodiaquine (ie, alleles in the crt and mdr1 genes). 2 Beshir KB Muwanguzi J Nader J et al. Prevalence of Plasmodium falciparum haplotypes associated with resistance to sulfadoxine–pyrimethamine and amodiaquine before and after upscaling of seasonal malaria chemoprevention in seven African countries: a genomics surveillance study. Lancet Infect Dis. 2022; (published online Oct 31.)https://doi.org/10.1016/S1473-3099(22)00593-X Summary Full Text Full Text PDF PubMed Scopus (4) Google Scholar Prevalence of Plasmodium falciparum haplotypes associated with resistance to sulfadoxine–pyrimethamine and amodiaquine before and after upscaling of seasonal malaria chemoprevention in seven African countries: a genomic surveillance studyIn seven African countries, evidence of a significant reduction in parasite carriage among children receiving seasonal malaria chemoprevention was found 2 years after intervention scale-up. Combined resistance-associated haplotypes remained rare, and seasonal malaria chemoprevention with sulfadoxine–pyrimethamine and amodiaquine is expected to retain effectiveness. The threat of future erosion of effectiveness due to dhps variant haplotypes requires further monitoring. Full-Text PDF Open Access" @default.
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• W4307908369 date "2023-03-01" @default.
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• W4307908369 title "Usefulness of seasonal malaria chemoprevention in the Sahel" @default.
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• W4307908369 doi "https://doi.org/10.1016/s1473-3099(22)00654-5" @default.
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