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- W4307918985 abstract "Abstract The hippocampus is a complex structure composed of distinct subfields. It has been central to understanding neural foundations of episodic memory. In the current cross‐sectional study, using a large sample of 830, 3‐ to 21‐year‐olds from a unique, publicly available dataset we examined the following questions: (1) Is there elevated grey matter volume of the hippocampus and subfields in late compared to early development? (2) How does hippocampal volume compare with the rest of the cerebral cortex at different developmental stages? and (3) What is the relation between hippocampal volume and connectivity with episodic memory performance? We found hippocampal subfield volumes exhibited a nonlinear relation with age and showed a lag in volumetric change with age when compared to adjacent cortical regions (e.g., entorhinal cortex). We also observed a significant reduction in cortical volume across older cohorts, while hippocampal volume showed the opposite pattern. In addition to age‐related differences in gray matter volume, dentate gyrus/cornu ammonis 3 volume was significantly related to episodic memory. We did not, however, find any associations with episodic memory performance and connectivity through the uncinate fasciculus, fornix, or cingulum. The results are discussed in the context of current research and theories of hippocampal development and its relation to episodic memory." @default.
- W4307918985 created "2022-11-06" @default.
- W4307918985 creator A5001323150 @default.
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- W4307918985 date "2022-10-31" @default.
- W4307918985 modified "2023-09-26" @default.
- W4307918985 title "Volumetric development of hippocampal subfields and hippocampal white matter connectivity: Relationship with episodic memory" @default.
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