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- W4307938417 abstract "This study investigated the effects of moderately increasing medium viscosity through two viscosity enhancing agents (VEA) (HPMC and sucrose) on the intrinsic dissolution of a BCS class II drug (ibuprofen). The differences in intrinsic dissolution were characterized through the estimation of a diffusion coefficient (D) of ibuprofen in different media with the Levich equation. Increasing viscosity decreased the intrinsic dissolution rate of ibuprofen with both VEAs. The calculated D from intrinsic dissolution data overestimated the experimental value, but the results suggest that intrinsic dissolution could be used as a tool to estimate a relative change in D in different viscosities. " @default.
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- W4307938417 date "2022-11-03" @default.
- W4307938417 modified "2023-10-01" @default.
- W4307938417 title "Assessing the effect of moderately increasing medium viscosity on the intrinsic dissolution rate and diffusion coefficient of ibuprofen particles" @default.
- W4307938417 doi "https://doi.org/10.5920/bjpharm.1130" @default.
- W4307938417 hasPublicationYear "2022" @default.
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