Matches in SemOpenAlex for { <https://semopenalex.org/work/W4307940215> ?p ?o ?g. }
- W4307940215 endingPage "7326" @default.
- W4307940215 startingPage "7326" @default.
- W4307940215 abstract "N-rich organic materials bearing polyphenolic moieties in their building networks and nanoscale porosities are very demanding in the context of designing efficient biomaterials or drug carriers for the cancer treatment. Here, we report the synthesis of a new triazine-based secondary-amine- and imine-linked polyphenolic porous organic polymer material TrzTFPPOP and explored its potential for in vitro anticancer activity on the human colorectal carcinoma (HCT 116) cell line. This functionalized (-OH, -NH-, -C=N-) organic material displayed an exceptionally high BET surface area of 2140 m2 g-1 along with hierarchical porosity (micropores and mesopores), and it induced apoptotic changes leading to high efficiency in colon cancer cell destruction via p53-regulated DNA damage pathway. The IC30, IC50, and IC70 values obtained from the MTT assay are 1.24, 3.25, and 5.25 μg/mL, respectively." @default.
- W4307940215 created "2022-11-06" @default.
- W4307940215 creator A5004788402 @default.
- W4307940215 creator A5020033035 @default.
- W4307940215 creator A5020388476 @default.
- W4307940215 creator A5043502752 @default.
- W4307940215 creator A5057823980 @default.
- W4307940215 creator A5086070290 @default.
- W4307940215 creator A5088198697 @default.
- W4307940215 date "2022-10-28" @default.
- W4307940215 modified "2023-09-27" @default.
- W4307940215 title "N-Rich, Polyphenolic Porous Organic Polymer and Its In Vitro Anticancer Activity on Colorectal Cancer" @default.
- W4307940215 cites W1992903999 @default.
- W4307940215 cites W1996830477 @default.
- W4307940215 cites W2009712659 @default.
- W4307940215 cites W2041855679 @default.
- W4307940215 cites W2054406083 @default.
- W4307940215 cites W2074693879 @default.
- W4307940215 cites W2077431908 @default.
- W4307940215 cites W2091979118 @default.
- W4307940215 cites W2096005449 @default.
- W4307940215 cites W2108638396 @default.
- W4307940215 cites W2138536939 @default.
- W4307940215 cites W2151467658 @default.
- W4307940215 cites W2172915374 @default.
- W4307940215 cites W2230354098 @default.
- W4307940215 cites W2510478131 @default.
- W4307940215 cites W2564707016 @default.
- W4307940215 cites W2586716011 @default.
- W4307940215 cites W2605595400 @default.
- W4307940215 cites W2749559405 @default.
- W4307940215 cites W2767319871 @default.
- W4307940215 cites W2783888971 @default.
- W4307940215 cites W2785315092 @default.
- W4307940215 cites W2790775088 @default.
- W4307940215 cites W2809727850 @default.
- W4307940215 cites W2809915751 @default.
- W4307940215 cites W2884818090 @default.
- W4307940215 cites W2886152898 @default.
- W4307940215 cites W2896089400 @default.
- W4307940215 cites W2910018406 @default.
- W4307940215 cites W2951071083 @default.
- W4307940215 cites W2972067996 @default.
- W4307940215 cites W2974709888 @default.
- W4307940215 cites W2991258270 @default.
- W4307940215 cites W3003716272 @default.
- W4307940215 cites W3018714945 @default.
- W4307940215 cites W3021488066 @default.
- W4307940215 cites W3033472536 @default.
- W4307940215 cites W3036299581 @default.
- W4307940215 cites W3045227647 @default.
- W4307940215 cites W3071626627 @default.
- W4307940215 cites W3080216539 @default.
- W4307940215 cites W3104725503 @default.
- W4307940215 cites W3118393993 @default.
- W4307940215 cites W3118721388 @default.
- W4307940215 cites W3123188618 @default.
- W4307940215 cites W3135541738 @default.
- W4307940215 cites W3158430989 @default.
- W4307940215 cites W3207215701 @default.
- W4307940215 cites W4200154134 @default.
- W4307940215 cites W4286444132 @default.
- W4307940215 cites W950131151 @default.
- W4307940215 cites W97766958 @default.
- W4307940215 doi "https://doi.org/10.3390/molecules27217326" @default.
- W4307940215 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36364150" @default.
- W4307940215 hasPublicationYear "2022" @default.
- W4307940215 type Work @default.
- W4307940215 citedByCount "3" @default.
- W4307940215 countsByYear W43079402152023 @default.
- W4307940215 crossrefType "journal-article" @default.
- W4307940215 hasAuthorship W4307940215A5004788402 @default.
- W4307940215 hasAuthorship W4307940215A5020033035 @default.
- W4307940215 hasAuthorship W4307940215A5020388476 @default.
- W4307940215 hasAuthorship W4307940215A5043502752 @default.
- W4307940215 hasAuthorship W4307940215A5057823980 @default.
- W4307940215 hasAuthorship W4307940215A5086070290 @default.
- W4307940215 hasAuthorship W4307940215A5088198697 @default.
- W4307940215 hasBestOaLocation W43079402151 @default.
- W4307940215 hasConcept C121608353 @default.
- W4307940215 hasConcept C12554922 @default.
- W4307940215 hasConcept C126322002 @default.
- W4307940215 hasConcept C151730666 @default.
- W4307940215 hasConcept C161790260 @default.
- W4307940215 hasConcept C171250308 @default.
- W4307940215 hasConcept C178790620 @default.
- W4307940215 hasConcept C185592680 @default.
- W4307940215 hasConcept C190283241 @default.
- W4307940215 hasConcept C192562407 @default.
- W4307940215 hasConcept C202751555 @default.
- W4307940215 hasConcept C2777752497 @default.
- W4307940215 hasConcept C2778004101 @default.
- W4307940215 hasConcept C2779343474 @default.
- W4307940215 hasConcept C521977710 @default.
- W4307940215 hasConcept C526805850 @default.
- W4307940215 hasConcept C55493867 @default.
- W4307940215 hasConcept C6648577 @default.
- W4307940215 hasConcept C70899900 @default.