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- W4307940231 abstract "Glioma is the most common intracranial malignant tumor, and the current main standard treatment option is a combination of tumor surgical resection, chemotherapy and radiotherapy. Due to the terribly poor five-year survival rate of patients with gliomas and the high recurrence rate of gliomas, some new and efficient therapeutic strategies are expected. Recently, ferroptosis, as a new form of cell death, has played a significant role in the treatment of gliomas. Specifically, studies have revealed key processes of ferroptosis, including iron overload in cells, occurrence of lipid peroxidation, inactivation of cysteine/glutathione antiporter system Xc− (xCT) and glutathione peroxidase 4 (GPX4). In the present review, we summarized the molecular mechanisms of ferroptosis and introduced the application and challenges of ferroptosis in the development and treatment of gliomas. Moreover, we highlighted the therapeutic opportunities of manipulating ferroptosis to improve glioma treatments, which may improve the clinical outcome." @default.
- W4307940231 created "2022-11-06" @default.
- W4307940231 creator A5014466461 @default.
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- W4307940231 creator A5070352390 @default.
- W4307940231 creator A5076497603 @default.
- W4307940231 date "2022-10-28" @default.
- W4307940231 modified "2023-10-14" @default.
- W4307940231 title "Ferroptosis and Its Potential Role in Glioma: From Molecular Mechanisms to Therapeutic Opportunities" @default.
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