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- W4307961031 endingPage "2231" @default.
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- W4307961031 abstract "Abstract A substantial global health burden is associated with neurotoxicity caused by lead (Pb) exposure and the common mechanism of this toxicity is mainly via oxidative damage. Curcumin has remarkable pharmacological activities but remains clinically constrained due to its poor bioavailability when orally administered. Currently, cockle shell‐derived calcium carbonate nanoparticle (CSCaCO 3 NP) is gaining more acceptance in nanomedicine as a nanocarrier to various therapeutics. This study aimed at investigating the ameliorative effect of curcumin‐loaded CSCaCO 3 NP (Cur‐CSCaCO 3 NP) on lead‐induced neurotoxicity in rats. A total of 36 male Sprague–Dawley rats were randomly assigned into five groups. Each group consists of 6 rats apart from the control group which consists of 12 rats. During the 4 weeks induction phase, all rats received a flat dose of 50 mg/kg of lead while the control group received normal saline. The treatment phase lasted for 4 weeks, and all rats received various doses of treatments as follows: group C (Cur 100) received 100 mg/kg of curcumin, group D (Cur‐CSCaCO 3 NP 50) received 50 mg/kg of Cur‐CSCaCO 3 NP, and group E (Cur‐CSCaCO 3 NP 100) received 100 mg/kg of Cur‐CSCaCO 3 NP. The motor function test was carried out using the horizontal bar method. The cerebral and cerebellar oxidative biomarker levels were estimated using ELISA and enzyme assay kits. Lead‐administered rats revealed a significant decrease in motor scores and SOD activities with a resultant increase in MDA levels. Furthermore, marked cellular death of the cerebral and cerebellar cortex was observed. Conversely, treatment with Cur‐CSCaCO 3 NP demonstrated enhanced ameliorative effects when compared with free curcumin treatment by significantly reversing the aforementioned alterations caused by lead. Thus, CSCaCO 3 NP enhanced the efficacy of curcumin by ameliorating the lead‐induced neurotoxicity via enhanced attenuation of oxidative stress." @default.
- W4307961031 created "2022-11-06" @default.
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- W4307961031 creator A5071893762 @default.
- W4307961031 creator A5081383359 @default.
- W4307961031 date "2022-10-30" @default.
- W4307961031 modified "2023-09-26" @default.
- W4307961031 title "Curcumin‐loaded cockle shell‐derived calcium carbonate nanoparticles ameliorates lead‐induced neurotoxicity in rats via attenuation of oxidative stress" @default.
- W4307961031 cites W1507621840 @default.
- W4307961031 cites W1758957447 @default.
- W4307961031 cites W1935621077 @default.
- W4307961031 cites W1969845678 @default.
- W4307961031 cites W1971422792 @default.
- W4307961031 cites W1972256665 @default.
- W4307961031 cites W1977191081 @default.
- W4307961031 cites W1981777504 @default.
- W4307961031 cites W1982645876 @default.
- W4307961031 cites W1992478997 @default.
- W4307961031 cites W1995905697 @default.
- W4307961031 cites W1996027116 @default.
- W4307961031 cites W1996720824 @default.
- W4307961031 cites W1997603886 @default.
- W4307961031 cites W2007999077 @default.
- W4307961031 cites W2020195616 @default.
- W4307961031 cites W2023545466 @default.
- W4307961031 cites W2027792640 @default.
- W4307961031 cites W2027833950 @default.
- W4307961031 cites W2029780227 @default.
- W4307961031 cites W2032096033 @default.
- W4307961031 cites W2033431239 @default.
- W4307961031 cites W2048591508 @default.
- W4307961031 cites W2053374578 @default.
- W4307961031 cites W2055584550 @default.
- W4307961031 cites W2059841383 @default.
- W4307961031 cites W2060662813 @default.
- W4307961031 cites W2079731478 @default.
- W4307961031 cites W2081970712 @default.
- W4307961031 cites W2083248581 @default.
- W4307961031 cites W2088242076 @default.
- W4307961031 cites W2097399046 @default.
- W4307961031 cites W2100625035 @default.
- W4307961031 cites W2101779356 @default.
- W4307961031 cites W2128426922 @default.
- W4307961031 cites W2146113829 @default.
- W4307961031 cites W2151699770 @default.
- W4307961031 cites W2154395565 @default.
- W4307961031 cites W2154733522 @default.
- W4307961031 cites W2170551565 @default.
- W4307961031 cites W2181581228 @default.
- W4307961031 cites W2210114002 @default.
- W4307961031 cites W2326385763 @default.
- W4307961031 cites W2404870875 @default.
- W4307961031 cites W2411154620 @default.
- W4307961031 cites W2416347552 @default.
- W4307961031 cites W2522138202 @default.
- W4307961031 cites W2558086882 @default.
- W4307961031 cites W2566414983 @default.
- W4307961031 cites W2574761932 @default.
- W4307961031 cites W2576154328 @default.
- W4307961031 cites W2588338305 @default.
- W4307961031 cites W2591026680 @default.
- W4307961031 cites W2604634793 @default.
- W4307961031 cites W2612455949 @default.
- W4307961031 cites W2613269927 @default.
- W4307961031 cites W2696164464 @default.
- W4307961031 cites W2752944051 @default.
- W4307961031 cites W2754261921 @default.
- W4307961031 cites W2765726410 @default.
- W4307961031 cites W2766083858 @default.
- W4307961031 cites W2792425408 @default.
- W4307961031 cites W2793637366 @default.
- W4307961031 cites W2802112449 @default.
- W4307961031 cites W2803499852 @default.
- W4307961031 cites W2806487170 @default.
- W4307961031 cites W2806822754 @default.
- W4307961031 cites W2809885438 @default.
- W4307961031 cites W2811125117 @default.
- W4307961031 cites W2891244187 @default.
- W4307961031 cites W2896417688 @default.
- W4307961031 cites W2907769303 @default.
- W4307961031 cites W2911738675 @default.
- W4307961031 cites W2914817934 @default.
- W4307961031 cites W2917242485 @default.
- W4307961031 cites W2920763895 @default.
- W4307961031 cites W2933145083 @default.
- W4307961031 cites W2935316630 @default.
- W4307961031 cites W2946404004 @default.
- W4307961031 cites W2962965421 @default.
- W4307961031 cites W2971377277 @default.
- W4307961031 cites W2990131383 @default.
- W4307961031 cites W4226119471 @default.
- W4307961031 cites W4250699538 @default.
- W4307961031 cites W4285785653 @default.