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- W4307964979 abstract "Abstract Ferredoxins are small iron-sulfur proteins and key players in essential metabolic pathways. Among all types, 3Fe-4S ferredoxins are less studied mostly due to anaerobic requirements. Their complexes with cy tochrome P 450 redox partners have not been structurally characterized. In the present work, we solved the structures of both 3Fe-4S ferredoxins from M. tuberculosis - Fdx alone and the fusion FdxE–CYP143. Our SPR analysis demonstrated a high affinity binding of FdxE to CYP143. According to SAXS data, the same complex is present in solution. The structure reveals extended multipoint interactions and the shape/charge complementarity of redox partners. Furthermore, FdxE binding induced conformational changes in CYP143 as evident from the solved CYP143 structure alone. The comparison of FdxE–CYP143 and modeled Fdx–CYP51 complexes further revealed the specificity of ferredoxins. Our results illuminate the diversity of electron transfer complexes for the production of different secondary metabolites." @default.
- W4307964979 created "2022-11-06" @default.
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- W4307964979 date "2022-11-02" @default.
- W4307964979 modified "2023-09-30" @default.
- W4307964979 title "Structural insights into 3Fe-4S ferredoxins diversity in<i>M.tuberculosis</i>highlighted by a first redox complex with P450" @default.
- W4307964979 cites W1968132781 @default.
- W4307964979 cites W1981346588 @default.
- W4307964979 cites W1984084102 @default.
- W4307964979 cites W2000305584 @default.
- W4307964979 cites W2003381825 @default.
- W4307964979 cites W2021321407 @default.
- W4307964979 cites W2027797186 @default.
- W4307964979 cites W2040057010 @default.
- W4307964979 cites W2040159113 @default.
- W4307964979 cites W2040760712 @default.
- W4307964979 cites W2042452521 @default.
- W4307964979 cites W2045494733 @default.
- W4307964979 cites W2047214756 @default.
- W4307964979 cites W2060939270 @default.
- W4307964979 cites W2066650866 @default.
- W4307964979 cites W2071534637 @default.
- W4307964979 cites W2082876077 @default.
- W4307964979 cites W2090079874 @default.
- W4307964979 cites W2100489286 @default.
- W4307964979 cites W2106411950 @default.
- W4307964979 cites W2106768806 @default.
- W4307964979 cites W2108921801 @default.
- W4307964979 cites W2124026197 @default.
- W4307964979 cites W2127130852 @default.
- W4307964979 cites W2136651168 @default.
- W4307964979 cites W2138431170 @default.
- W4307964979 cites W2138767311 @default.
- W4307964979 cites W2141825656 @default.
- W4307964979 cites W2145439094 @default.
- W4307964979 cites W2154197653 @default.
- W4307964979 cites W2159211495 @default.
- W4307964979 cites W2162244749 @default.
- W4307964979 cites W2163341755 @default.
- W4307964979 cites W2164361934 @default.
- W4307964979 cites W2165335121 @default.
- W4307964979 cites W2176126080 @default.
- W4307964979 cites W2286701638 @default.
- W4307964979 cites W2305834606 @default.
- W4307964979 cites W2474143322 @default.
- W4307964979 cites W2527411440 @default.
- W4307964979 cites W2558795906 @default.
- W4307964979 cites W2707646777 @default.
- W4307964979 cites W2747416177 @default.
- W4307964979 cites W2747992112 @default.
- W4307964979 cites W2765322245 @default.
- W4307964979 cites W2793558437 @default.
- W4307964979 cites W2800057751 @default.
- W4307964979 cites W2888208256 @default.
- W4307964979 cites W2888605730 @default.
- W4307964979 cites W2914236087 @default.
- W4307964979 cites W2965289466 @default.
- W4307964979 cites W2973457155 @default.
- W4307964979 cites W2977366709 @default.
- W4307964979 cites W3009192701 @default.
- W4307964979 cites W3012521310 @default.
- W4307964979 cites W3030946458 @default.
- W4307964979 cites W3091475389 @default.
- W4307964979 cites W3091861600 @default.
- W4307964979 cites W3103541536 @default.
- W4307964979 cites W3110561420 @default.
- W4307964979 cites W3119910298 @default.
- W4307964979 cites W3125903257 @default.
- W4307964979 cites W3164791910 @default.
- W4307964979 cites W3203271934 @default.
- W4307964979 cites W3208518196 @default.
- W4307964979 cites W4220777742 @default.
- W4307964979 cites W4225307741 @default.
- W4307964979 cites W4236823855 @default.
- W4307964979 cites W4245740623 @default.
- W4307964979 cites W4248872320 @default.
- W4307964979 cites W4281790889 @default.
- W4307964979 cites W4283733180 @default.