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• W4307967277 abstract "Abstract Oncogenic Merkel cell polyomavirus (MCPyV) provokes a widespread and asymptomatic infection in humans. Herein, sera from healthy children and young adults (HC, n = 344) aged 0–20 years old were evaluated for anti‐MCPyV immunoglobulin G (IgG) and IgM antibodies employing a recently developed immunoassay. Serum MCPyV IgG data from healthy subjects (HS, n = 510) and elderlies (ES, n = 226), aged 21–65/66–100 years old, from our previous studies, were included. The anti‐MCPyV IgG and IgM rates in HC sera were 40.7% and 29.7%, respectively. A lower prevalence of anti‐MCPyV IgGs was found in HC aged 0–5 years old (13%) compared to 6–10 (52.3%), 11–15 (60.5%) and 16–20 years old (61.6%) cohorts. Age‐stratified HCs exhibited similar anti‐MCPyV IgM rates (27.9%–32.9%). Serological profiles indicated that anti‐MCPyV IgGs and IgMs had low optical densities (ODs) during the first years of life, while IgM ODs appeared to decrease throughout young adulthood. A lower anti‐MCPyV IgGs rate was found in HC (40.7%) than HS (61.8%) and ES (63.7%). Upon the 5‐years range age‐stratification, a lower anti‐MCPyV IgGs rate was found in the younger HC cohort aged 0–5 years old compared to the remaining older HC/HS/ES cohorts (52.3%–72%). The younger HC cohort exhibited the lowest anti‐MCPyV IgG ODs than the older cohorts. Low anti‐MCPyV IgMs rates and ODs were found in the 21–25 (17.5%) and 26–30 (7.7%) years old cohorts. Our data indicate that, upon an early‐in‐life seroconversion, the seropositivity for oncogenic MCPyV peaks in late childhood/young adulthood and remains at high prevalence and relatively stable throughout life." @default.
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• W4307967277 date "2022-12-11" @default.
• W4307967277 modified "2023-10-16" @default.
• W4307967277 title "Immunological evidence of an early seroconversion to oncogenic Merkel cell polyomavirus in healthy children and young adults" @default.
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• W4307967277 doi "https://doi.org/10.1111/imm.13601" @default.
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