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- W4307970939 endingPage "2205489" @default.
- W4307970939 startingPage "2205489" @default.
- W4307970939 abstract "Current diabetic wound treatments remain unsatisfactory due to the lack of a comprehensive strategy that can integrate strong applicability (tissue adhesiveness, shape adaptability, fast self-healability, and facile dressing change) with the initiation and smooth connection of the cascade wound healing processes. Herein, benefiting from the multifaceted bonding ability of tannic acid to metal ions and various polymers, a family of tannin-europium coordination complex crosslinked citrate-based mussel-inspired bioadhesives (TE-CMBAs) are specially developed for diabetic wound healing. TE-CMBAs can gel instantly (< 60 s), possess favorable shape-adaptability, considerable mechanical strengths, high elasticity, considerable wet tissue adhesiveness (≈40 kPa), favorable photothermal antimicrobial activity, excellent anti-oxidant activity, biocompatibility, and angiogenetic property. The reversible hydrogen bond crosslinking and sensitive metal-phenolic coordination also confers TE-CMBAs with self-healability, pH-responsive europium ion and TA releasing properties and on-demand removability upon mixing with borax solution, enabling convenient painless dressing change and the smooth connection of inflammatory microenvironment modulation, angiogenesis promotion, and effective extracellular matrix production leveraging the acidic pH condition of diabetic wounds. This adhesive dressing provides a comprehensive regenerative strategy for diabetic wound management and can be extended to other complicated tissue healing scenarios." @default.
- W4307970939 created "2022-11-06" @default.
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- W4307970939 date "2022-11-01" @default.
- W4307970939 modified "2023-10-16" @default.
- W4307970939 title "On‐Demand Removable Self‐Healing and pH‐Responsive Europium‐Releasing Adhesive Dressing Enables Inflammatory Microenvironment Modulation and Angiogenesis for Diabetic Wound Healing" @default.
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- W4307970939 doi "https://doi.org/10.1002/smll.202205489" @default.
- W4307970939 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36319477" @default.
- W4307970939 hasPublicationYear "2022" @default.
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