FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4307974103> ?p ?o ?g. }

• W4307974103 endingPage "1115" @default.
• W4307974103 startingPage "1108" @default.
• W4307974103 abstract "Oxidative stress plays an important role in the pathology of thyroid disorders. This study examined the effect of gallic acid (GA) on the oxidative status and expression of liver antioxidant genes including thioredoxin (TXN1 & TXN2) and thioredoxin reductase1 (TXNRd1) in hypo- and hyperthyroid rat models. Forty-nine male Wistar rats were randomly assigned into seven groups as follows: control group, hypothyroid and hyperthyroid groups respectively induced by propylthiouracil and levothyroxine, hypo- and hyper thyroid-treated groups (where the groups were separately treated with 50 and 100 mg/kg of GA daily, orally). The levels of thyroid hormones and serum oxidative stress markers were evaluated after 5 weeks. The relative expression of TXN1,2 and TXNRd1 genes was measured via real-time qRT-PCR. The mean level of total antioxidant capacity (TAC), malondialdehyde, and uric acid index diminished in the hypothyroid group. Increased TAC reached almost the level of control in hypothyroid groups treated with GA. Elevation of thiol index in the hypothyroid group was observed (p < 0.01), which diminished to the control level after GA treatment. The relative expression of TXN1, TXNRd1, and TXN2 genes in the hypothyroid and hyperthyroid groups significantly increased compared to the control group (p ≥ 0.05), but in the groups treated with GA, the expression of these genes declined significantly (p ≥ 0.05). Our results indicated GA can affect the expression of TXN system genes in the rat liver. Also, the results suggest GA has a more positive effect on modulating serum oxidative parameters in hypothyroid rat models than in hyperthyroid." @default.
• W4307974103 created "2022-11-06" @default.
• W4307974103 creator A5017678810 @default.
• W4307974103 creator A5021373781 @default.
• W4307974103 creator A5024582387 @default.
• W4307974103 creator A5025487907 @default.
• W4307974103 creator A5072988616 @default.
• W4307974103 date "2022-10-31" @default.
• W4307974103 modified "2023-10-01" @default.
• W4307974103 title "The molecular evaluation of thioredoxin (TXN1 & TXN2), thioredoxin reductase 1 (TXNRd1), and oxidative stress markers in a binary rat model of hypo- and hyperthyroidism after treatment with gallic acid" @default.
• W4307974103 cites W1504555765 @default.
• W4307974103 cites W1550909330 @default.
• W4307974103 cites W1927650744 @default.
• W4307974103 cites W1977941415 @default.
• W4307974103 cites W1999977463 @default.
• W4307974103 cites W2002593979 @default.
• W4307974103 cites W2004022011 @default.
• W4307974103 cites W2007734870 @default.
• W4307974103 cites W2009864041 @default.
• W4307974103 cites W2065314794 @default.
• W4307974103 cites W2065985218 @default.
• W4307974103 cites W2067036546 @default.
• W4307974103 cites W2072623280 @default.
• W4307974103 cites W2078409401 @default.
• W4307974103 cites W2088826552 @default.
• W4307974103 cites W2089314102 @default.
• W4307974103 cites W2115734998 @default.
• W4307974103 cites W2124101478 @default.
• W4307974103 cites W2140370824 @default.
• W4307974103 cites W2165292984 @default.
• W4307974103 cites W2174642539 @default.
• W4307974103 cites W2600689296 @default.
• W4307974103 cites W2621034172 @default.
• W4307974103 cites W2792411929 @default.
• W4307974103 cites W2905580912 @default.
• W4307974103 cites W2989429168 @default.
• W4307974103 cites W3008311686 @default.
• W4307974103 cites W3200513687 @default.
• W4307974103 doi "https://doi.org/10.1080/01480545.2022.2131812" @default.
• W4307974103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36314079" @default.
• W4307974103 hasPublicationYear "2022" @default.
• W4307974103 type Work @default.
• W4307974103 citedByCount "0" @default.
• W4307974103 crossrefType "journal-article" @default.
• W4307974103 hasAuthorship W4307974103A5017678810 @default.
• W4307974103 hasAuthorship W4307974103A5021373781 @default.
• W4307974103 hasAuthorship W4307974103A5024582387 @default.
• W4307974103 hasAuthorship W4307974103A5025487907 @default.
• W4307974103 hasAuthorship W4307974103A5072988616 @default.
• W4307974103 hasConcept C126322002 @default.
• W4307974103 hasConcept C134018914 @default.
• W4307974103 hasConcept C171269688 @default.
• W4307974103 hasConcept C185592680 @default.
• W4307974103 hasConcept C2775960720 @default.
• W4307974103 hasConcept C2776151105 @default.
• W4307974103 hasConcept C2778004101 @default.
• W4307974103 hasConcept C2778362808 @default.
• W4307974103 hasConcept C2778401633 @default.
• W4307974103 hasConcept C2778417266 @default.
• W4307974103 hasConcept C2779571634 @default.
• W4307974103 hasConcept C2779881121 @default.
• W4307974103 hasConcept C3623737 @default.
• W4307974103 hasConcept C526584372 @default.
• W4307974103 hasConcept C55493867 @default.
• W4307974103 hasConcept C71315377 @default.
• W4307974103 hasConcept C71924100 @default.
• W4307974103 hasConceptScore W4307974103C126322002 @default.
• W4307974103 hasConceptScore W4307974103C134018914 @default.
• W4307974103 hasConceptScore W4307974103C171269688 @default.
• W4307974103 hasConceptScore W4307974103C185592680 @default.
• W4307974103 hasConceptScore W4307974103C2775960720 @default.
• W4307974103 hasConceptScore W4307974103C2776151105 @default.
• W4307974103 hasConceptScore W4307974103C2778004101 @default.
• W4307974103 hasConceptScore W4307974103C2778362808 @default.
• W4307974103 hasConceptScore W4307974103C2778401633 @default.
• W4307974103 hasConceptScore W4307974103C2778417266 @default.
• W4307974103 hasConceptScore W4307974103C2779571634 @default.
• W4307974103 hasConceptScore W4307974103C2779881121 @default.
• W4307974103 hasConceptScore W4307974103C3623737 @default.
• W4307974103 hasConceptScore W4307974103C526584372 @default.
• W4307974103 hasConceptScore W4307974103C55493867 @default.
• W4307974103 hasConceptScore W4307974103C71315377 @default.
• W4307974103 hasConceptScore W4307974103C71924100 @default.
• W4307974103 hasFunder F4320323129 @default.
• W4307974103 hasIssue "6" @default.
• W4307974103 hasLocation W43079741031 @default.
• W4307974103 hasLocation W43079741032 @default.
• W4307974103 hasOpenAccess W4307974103 @default.
• W4307974103 hasPrimaryLocation W43079741031 @default.
• W4307974103 hasRelatedWork W1986172466 @default.
• W4307974103 hasRelatedWork W2010645160 @default.
• W4307974103 hasRelatedWork W2011960454 @default.
• W4307974103 hasRelatedWork W2069420617 @default.
• W4307974103 hasRelatedWork W2070995469 @default.
• W4307974103 hasRelatedWork W2079613337 @default.
• W4307974103 hasRelatedWork W2107664466 @default.
• W4307974103 hasRelatedWork W2155312245 @default.
• W4307974103 hasRelatedWork W2163236351 @default.

• next