Matches in SemOpenAlex for { <https://semopenalex.org/work/W4307981395> ?p ?o ?g. }
- W4307981395 endingPage "109312" @default.
- W4307981395 startingPage "109312" @default.
- W4307981395 abstract "In this review, we focus on prenatal opioid exposure (POE) given the significant concern for the mental health outcomes of children with parents affected by opioid use disorder (OUD) in the view of the current opioid crisis. We highlight some of the less explored interactions between developmental age and sex on synaptic plasticity and associated behavioral outcomes in preclinical POE research. We begin with an overview of the rich literature on hippocampal related behaviors and plasticity across POE exposure paradigms. We then discuss recent work on reward circuit dysregulation following POE. Additional risk factors such as early life stress (ELS) could further influence synaptic and behavioral outcomes of POE. Therefore, we include an overview on the use of preclinical ELS models where ELS exposure during key critical developmental periods confers considerable vulnerability to addiction and stress psychopathology. Here, we hope to highlight the similarity between POE and ELS on development and maintenance of opioid-induced plasticity and altered opioid-related behaviors where similar enduring plasticity in reward circuits may occur. We conclude the review with some of the limitations that should be considered in future investigations. This article is part of the Special Issue on 'Opioid-induced addiction'." @default.
- W4307981395 created "2022-11-07" @default.
- W4307981395 creator A5041947441 @default.
- W4307981395 creator A5048550774 @default.
- W4307981395 creator A5050632811 @default.
- W4307981395 creator A5059562228 @default.
- W4307981395 date "2023-01-01" @default.
- W4307981395 modified "2023-10-14" @default.
- W4307981395 title "Effects of prenatal opioid exposure on synaptic adaptations and behaviors across development" @default.
- W4307981395 cites W142375790 @default.
- W4307981395 cites W1492717422 @default.
- W4307981395 cites W1518423770 @default.
- W4307981395 cites W1520271859 @default.
- W4307981395 cites W1559705399 @default.
- W4307981395 cites W1593533288 @default.
- W4307981395 cites W1602139841 @default.
- W4307981395 cites W160745650 @default.
- W4307981395 cites W1700309272 @default.
- W4307981395 cites W1710963664 @default.
- W4307981395 cites W1764067125 @default.
- W4307981395 cites W1814212931 @default.
- W4307981395 cites W1888358006 @default.
- W4307981395 cites W1928590576 @default.
- W4307981395 cites W1963831674 @default.
- W4307981395 cites W1963895084 @default.
- W4307981395 cites W1964516189 @default.
- W4307981395 cites W1966375501 @default.
- W4307981395 cites W1966666459 @default.
- W4307981395 cites W1967428068 @default.
- W4307981395 cites W1973172035 @default.
- W4307981395 cites W1973824544 @default.
- W4307981395 cites W1978307048 @default.
- W4307981395 cites W1978818986 @default.
- W4307981395 cites W1979031324 @default.
- W4307981395 cites W1982176826 @default.
- W4307981395 cites W1983330905 @default.
- W4307981395 cites W1984956006 @default.
- W4307981395 cites W1987028639 @default.
- W4307981395 cites W1987629025 @default.
- W4307981395 cites W1988082976 @default.
- W4307981395 cites W1988405353 @default.
- W4307981395 cites W1993159694 @default.
- W4307981395 cites W1994302329 @default.
- W4307981395 cites W1995833581 @default.
- W4307981395 cites W1995956435 @default.
- W4307981395 cites W1996912271 @default.
- W4307981395 cites W1998486998 @default.
- W4307981395 cites W1999646306 @default.
- W4307981395 cites W2003262023 @default.
- W4307981395 cites W2004163425 @default.
- W4307981395 cites W2004771475 @default.
- W4307981395 cites W2005020429 @default.
- W4307981395 cites W2006729395 @default.
- W4307981395 cites W2008488411 @default.
- W4307981395 cites W2008589574 @default.
- W4307981395 cites W2009680578 @default.
- W4307981395 cites W2009839417 @default.
- W4307981395 cites W2012472811 @default.
- W4307981395 cites W2015843236 @default.
- W4307981395 cites W2018089173 @default.
- W4307981395 cites W2021601254 @default.
- W4307981395 cites W2022363910 @default.
- W4307981395 cites W2024238924 @default.
- W4307981395 cites W2025122498 @default.
- W4307981395 cites W2027385154 @default.
- W4307981395 cites W2027917639 @default.
- W4307981395 cites W2028100866 @default.
- W4307981395 cites W2028372287 @default.
- W4307981395 cites W2031021551 @default.
- W4307981395 cites W2031580286 @default.
- W4307981395 cites W2032656645 @default.
- W4307981395 cites W2033905798 @default.
- W4307981395 cites W2034154165 @default.
- W4307981395 cites W2035522065 @default.
- W4307981395 cites W2036990247 @default.
- W4307981395 cites W2037003853 @default.
- W4307981395 cites W2037730176 @default.
- W4307981395 cites W2040899392 @default.
- W4307981395 cites W2041164640 @default.
- W4307981395 cites W2041418210 @default.
- W4307981395 cites W2042085544 @default.
- W4307981395 cites W2043559838 @default.
- W4307981395 cites W2045121272 @default.
- W4307981395 cites W2045698590 @default.
- W4307981395 cites W2045821490 @default.
- W4307981395 cites W2046732597 @default.
- W4307981395 cites W2046804265 @default.
- W4307981395 cites W2047199487 @default.
- W4307981395 cites W2048025784 @default.
- W4307981395 cites W2048836606 @default.
- W4307981395 cites W2049627519 @default.
- W4307981395 cites W2050038083 @default.
- W4307981395 cites W2053660748 @default.
- W4307981395 cites W2056583643 @default.
- W4307981395 cites W2058849090 @default.
- W4307981395 cites W2059022502 @default.
- W4307981395 cites W2060077561 @default.
- W4307981395 cites W2061095064 @default.