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- W4307990089 abstract "As an in-depth understanding of immunotherapy continues to grow, current anticancer therapy research is increasingly focused on the tumor microenvironment (TME). MicroRNAs (miRNAs) play crucial roles in the regulation of genetic information and expression and mediate interactions between tumor cells and components in the TME, such as tumor-associated macrophages (macrophages). Macrophages are abundant in the TME, and their different polarization directions can promote or inhibit tumor growth and progression. By regulating biological behaviors, such as macrophage recruitment, infiltration, and polarization, miRNAs can affect various molecular pathways to regulate tumor progression and treatment response. In this review, we discuss in detail the effects of macrophages on tumors and the multifaceted effects of miRNAs on macrophages. We also discuss the potential clinical applications and prospects of targeted therapy based on miRNAs, novel clinical biomarkers, and drug delivery systems." @default.
- W4307990089 created "2022-11-07" @default.
- W4307990089 creator A5022135205 @default.
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- W4307990089 creator A5070054348 @default.
- W4307990089 creator A5077786954 @default.
- W4307990089 creator A5082429124 @default.
- W4307990089 date "2022-10-31" @default.
- W4307990089 modified "2023-10-14" @default.
- W4307990089 title "Crosstalk between Tumor-Associated Macrophages and MicroRNAs: A Key Role in Tumor Microenvironment" @default.
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