Matches in SemOpenAlex for { <https://semopenalex.org/work/W4307993602> ?p ?o ?g. }
- W4307993602 endingPage "36" @default.
- W4307993602 startingPage "23" @default.
- W4307993602 abstract "Primary sclerosing cholangitis (PSC) is a progressive liver disease with poor prognosis and no effective therapies to prevent progression. An aetiopathological link between PSC and gastrointestinal microbial dysbiosis has been suggested.To evaluate all potential medical therapies which may exert their effect in PSC by modulation of the gut-liver axis.We conducted a comprehensive scoping review of PubMed and Cochrane Library, including all articles evaluating an intervention aimed at manipulating the gastrointestinal microbiome in PSC.A wide range of therapies proposed altering the gastrointestinal microbiome for the treatment of PSC. In particular, these considered antibiotics including vancomycin, metronidazole, rifaximin, minocycline and azithromycin. However, few therapies have been investigated in randomised, placebo-controlled trials. Vancomycin has been the most widely studied antibiotic, with improvement in alkaline phosphatase reported in two randomised controlled trials, but with no data on disease progression. Unlike antibiotics, strategies such as faecal microbiota transplantation and dietary therapy can improve microbial diversity. However, since these have only been tested in small numbers of patients, robust efficacy data are currently lacking.The gut-liver axis is increasingly considered a potential target for the treatment of PSC. However, no therapies have been demonstrated to improve transplant-free survival. Innovative and well-designed clinical trials of microbiome-targeted therapies with long-term follow-up are required for this orphan disease." @default.
- W4307993602 created "2022-11-07" @default.
- W4307993602 creator A5000863078 @default.
- W4307993602 creator A5007139358 @default.
- W4307993602 creator A5020065368 @default.
- W4307993602 creator A5071481733 @default.
- W4307993602 date "2022-11-02" @default.
- W4307993602 modified "2023-10-14" @default.
- W4307993602 title "Systematic review: microbial manipulation as therapy for primary sclerosing cholangitis" @default.
- W4307993602 cites W1479884833 @default.
- W4307993602 cites W1617200419 @default.
- W4307993602 cites W1915780233 @default.
- W4307993602 cites W1971668211 @default.
- W4307993602 cites W1993535010 @default.
- W4307993602 cites W1995534781 @default.
- W4307993602 cites W2006412887 @default.
- W4307993602 cites W2015161836 @default.
- W4307993602 cites W2018381077 @default.
- W4307993602 cites W2018878564 @default.
- W4307993602 cites W2028005970 @default.
- W4307993602 cites W2030752472 @default.
- W4307993602 cites W2033755132 @default.
- W4307993602 cites W2040286034 @default.
- W4307993602 cites W2049914976 @default.
- W4307993602 cites W2055959209 @default.
- W4307993602 cites W2057955069 @default.
- W4307993602 cites W2062111585 @default.
- W4307993602 cites W2072921310 @default.
- W4307993602 cites W2099360240 @default.
- W4307993602 cites W2100862969 @default.
- W4307993602 cites W2102005215 @default.
- W4307993602 cites W2108230902 @default.
- W4307993602 cites W2108826619 @default.
- W4307993602 cites W2119114528 @default.
- W4307993602 cites W2125894152 @default.
- W4307993602 cites W2138196119 @default.
- W4307993602 cites W2142286221 @default.
- W4307993602 cites W2147512343 @default.
- W4307993602 cites W2148171446 @default.
- W4307993602 cites W2174303134 @default.
- W4307993602 cites W2186911163 @default.
- W4307993602 cites W2254262042 @default.
- W4307993602 cites W2259743485 @default.
- W4307993602 cites W2303705264 @default.
- W4307993602 cites W2399440084 @default.
- W4307993602 cites W2408052000 @default.
- W4307993602 cites W2511281246 @default.
- W4307993602 cites W2530349027 @default.
- W4307993602 cites W2586374101 @default.
- W4307993602 cites W2591423554 @default.
- W4307993602 cites W2601282333 @default.
- W4307993602 cites W2605581216 @default.
- W4307993602 cites W2606167666 @default.
- W4307993602 cites W2611666938 @default.
- W4307993602 cites W2625740605 @default.
- W4307993602 cites W2728654001 @default.
- W4307993602 cites W2735259022 @default.
- W4307993602 cites W2738454635 @default.
- W4307993602 cites W2738962050 @default.
- W4307993602 cites W2749270116 @default.
- W4307993602 cites W2757594951 @default.
- W4307993602 cites W2762994022 @default.
- W4307993602 cites W2787746816 @default.
- W4307993602 cites W2791978017 @default.
- W4307993602 cites W2803499191 @default.
- W4307993602 cites W2804619508 @default.
- W4307993602 cites W2883054118 @default.
- W4307993602 cites W2887447992 @default.
- W4307993602 cites W2888067148 @default.
- W4307993602 cites W2898630509 @default.
- W4307993602 cites W2901937827 @default.
- W4307993602 cites W2905044063 @default.
- W4307993602 cites W2909724008 @default.
- W4307993602 cites W2909878330 @default.
- W4307993602 cites W2911269279 @default.
- W4307993602 cites W2921805808 @default.
- W4307993602 cites W2937834684 @default.
- W4307993602 cites W2947046480 @default.
- W4307993602 cites W2954128657 @default.
- W4307993602 cites W2961378238 @default.
- W4307993602 cites W3087505454 @default.
- W4307993602 cites W3087574823 @default.
- W4307993602 cites W3109336373 @default.
- W4307993602 cites W3158249546 @default.
- W4307993602 cites W3193898248 @default.
- W4307993602 cites W4233893512 @default.
- W4307993602 cites W4235763806 @default.
- W4307993602 cites W4255102446 @default.
- W4307993602 cites W4294405992 @default.
- W4307993602 cites W4307993602 @default.
- W4307993602 cites W4376601183 @default.
- W4307993602 doi "https://doi.org/10.1111/apt.17251" @default.
- W4307993602 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36324251" @default.
- W4307993602 hasPublicationYear "2022" @default.
- W4307993602 type Work @default.
- W4307993602 citedByCount "2" @default.
- W4307993602 countsByYear W43079936022022 @default.
- W4307993602 countsByYear W43079936022023 @default.