Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308001638> ?p ?o ?g. }
- W4308001638 endingPage "184" @default.
- W4308001638 startingPage "169" @default.
- W4308001638 abstract "We investigated the role of cancer stem cells (CSCs) in a population of triple-negative breast cancer (TNBC) cells that are resistant to apoptosis. A human breast cancer cell population capable of inducing p53 expression with doxycycline (Dox) was created and used as an untreated control (UT). After the addition of Dox to UT for 5 days, the cell population reconstituted with cells showing resistance to apoptosis was named RE. Fluorescence-activated cell sorting (FACS) and immunostaining revealed that after the addition of Dox, the ratio of cells in the S and G2/M phases decreased in UT as apoptosis proceeded, but did not markedly change in apoptosis-resistant RE. CSC-like cells in RE exhibited a cell morphology with a larger ratio of the major/minor axis than UT. FACS showed that RE had a higher proportion of CSC-like cells and contained more CD44+CD24- mesenchymal CSCs than ALDH1A3+ epithelial-like CSCs. In a Matrigel invasion assay, UT was more likely to form a three-dimensional cell population, whereas RE exhibited a planar population, higher migration ability, and the up-regulated expression of epithelial-mesenchymal transition-related genes. These results provide insights into the mechanisms by which TNBC cells acquire treatment resistance at the time of recurrence." @default.
- W4308001638 created "2022-11-07" @default.
- W4308001638 creator A5001553671 @default.
- W4308001638 creator A5002455849 @default.
- W4308001638 creator A5005164101 @default.
- W4308001638 creator A5007098954 @default.
- W4308001638 creator A5012086986 @default.
- W4308001638 creator A5049259831 @default.
- W4308001638 creator A5055850706 @default.
- W4308001638 creator A5080674295 @default.
- W4308001638 creator A5086172272 @default.
- W4308001638 date "2022-10-28" @default.
- W4308001638 modified "2023-10-03" @default.
- W4308001638 title "Role of Cancer Stem-like Cells in the Process of Invasion and Mesenchymal Transformation by a Reconstituted Triple-negative Breast Cancer Cell Population Resistant to p53-induced Apoptosis" @default.
- W4308001638 cites W1490094425 @default.
- W4308001638 cites W1964081206 @default.
- W4308001638 cites W1975821156 @default.
- W4308001638 cites W1979243197 @default.
- W4308001638 cites W1983364027 @default.
- W4308001638 cites W1986857654 @default.
- W4308001638 cites W1991617381 @default.
- W4308001638 cites W1994242450 @default.
- W4308001638 cites W1997476786 @default.
- W4308001638 cites W1997688669 @default.
- W4308001638 cites W2007421933 @default.
- W4308001638 cites W2012376126 @default.
- W4308001638 cites W2014691022 @default.
- W4308001638 cites W2018586847 @default.
- W4308001638 cites W2019774245 @default.
- W4308001638 cites W2023427658 @default.
- W4308001638 cites W2042198997 @default.
- W4308001638 cites W2043895269 @default.
- W4308001638 cites W2047172303 @default.
- W4308001638 cites W2048735580 @default.
- W4308001638 cites W2051002945 @default.
- W4308001638 cites W2055312095 @default.
- W4308001638 cites W2060937867 @default.
- W4308001638 cites W2073566510 @default.
- W4308001638 cites W2074420260 @default.
- W4308001638 cites W2076446882 @default.
- W4308001638 cites W2090699761 @default.
- W4308001638 cites W2100826888 @default.
- W4308001638 cites W2101179492 @default.
- W4308001638 cites W2104818667 @default.
- W4308001638 cites W2105504936 @default.
- W4308001638 cites W2106332137 @default.
- W4308001638 cites W2130524883 @default.
- W4308001638 cites W2132820593 @default.
- W4308001638 cites W2137586381 @default.
- W4308001638 cites W2143383125 @default.
- W4308001638 cites W2145013849 @default.
- W4308001638 cites W2165286055 @default.
- W4308001638 cites W2167279371 @default.
- W4308001638 cites W2170602872 @default.
- W4308001638 cites W2262500441 @default.
- W4308001638 cites W2465250101 @default.
- W4308001638 cites W2534540013 @default.
- W4308001638 cites W2561035699 @default.
- W4308001638 cites W2607042702 @default.
- W4308001638 cites W2754823840 @default.
- W4308001638 cites W2774323335 @default.
- W4308001638 cites W2803256996 @default.
- W4308001638 cites W2807762373 @default.
- W4308001638 cites W2904799526 @default.
- W4308001638 cites W2953057790 @default.
- W4308001638 cites W2966151337 @default.
- W4308001638 cites W2969263349 @default.
- W4308001638 cites W2972270957 @default.
- W4308001638 cites W2981076470 @default.
- W4308001638 cites W3154027012 @default.
- W4308001638 cites W4237479280 @default.
- W4308001638 cites W983771422 @default.
- W4308001638 doi "https://doi.org/10.1267/ahc.22-00076" @default.
- W4308001638 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36405550" @default.
- W4308001638 hasPublicationYear "2022" @default.
- W4308001638 type Work @default.
- W4308001638 citedByCount "1" @default.
- W4308001638 countsByYear W43080016382023 @default.
- W4308001638 crossrefType "journal-article" @default.
- W4308001638 hasAuthorship W4308001638A5001553671 @default.
- W4308001638 hasAuthorship W4308001638A5002455849 @default.
- W4308001638 hasAuthorship W4308001638A5005164101 @default.
- W4308001638 hasAuthorship W4308001638A5007098954 @default.
- W4308001638 hasAuthorship W4308001638A5012086986 @default.
- W4308001638 hasAuthorship W4308001638A5049259831 @default.
- W4308001638 hasAuthorship W4308001638A5055850706 @default.
- W4308001638 hasAuthorship W4308001638A5080674295 @default.
- W4308001638 hasAuthorship W4308001638A5086172272 @default.
- W4308001638 hasBestOaLocation W43080016381 @default.
- W4308001638 hasConcept C121608353 @default.
- W4308001638 hasConcept C1491633281 @default.
- W4308001638 hasConcept C185592680 @default.
- W4308001638 hasConcept C190283241 @default.
- W4308001638 hasConcept C198826908 @default.
- W4308001638 hasConcept C2778608917 @default.
- W4308001638 hasConcept C2779013556 @default.
- W4308001638 hasConcept C2780110267 @default.
- W4308001638 hasConcept C2780394083 @default.