Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308010197> ?p ?o ?g. }
Showing items 1 to 58 of
58
with 100 items per page.
- W4308010197 abstract "Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2). We harnessed the power of unbiased, whole transcriptome differential gene expression analysis, utilizing primary patient cells and tissues to discover genes whose expression defines ALS using published data (3, 4). We found significant differential expression of COL19A1, encoding collagen type XIX alpha 1 chain, in the skeletal muscle of patients with ALS. COL19A1 was also differentially expressed in the induced pluripotent stem cell (iPSC)-derived motor neurons of patients with ALS. COL19A1 transcript was present at significantly higher levels in ALS patient skeletal muscle as compared to control skeletal muscle. These analyses will begin to define the transcriptional landscape of ALS." @default.
- W4308010197 created "2022-11-07" @default.
- W4308010197 creator A5024900493 @default.
- W4308010197 date "2022-11-01" @default.
- W4308010197 modified "2023-09-27" @default.
- W4308010197 title "Differential expression of COL19A1 in amyotrophic lateral sclerosis." @default.
- W4308010197 doi "https://doi.org/10.31219/osf.io/tw37r" @default.
- W4308010197 hasPublicationYear "2022" @default.
- W4308010197 type Work @default.
- W4308010197 citedByCount "0" @default.
- W4308010197 crossrefType "posted-content" @default.
- W4308010197 hasAuthorship W4308010197A5024900493 @default.
- W4308010197 hasBestOaLocation W43080101971 @default.
- W4308010197 hasConcept C104317684 @default.
- W4308010197 hasConcept C105702510 @default.
- W4308010197 hasConcept C107459253 @default.
- W4308010197 hasConcept C142724271 @default.
- W4308010197 hasConcept C145103041 @default.
- W4308010197 hasConcept C150194340 @default.
- W4308010197 hasConcept C162317418 @default.
- W4308010197 hasConcept C169760540 @default.
- W4308010197 hasConcept C2779134260 @default.
- W4308010197 hasConcept C2779959927 @default.
- W4308010197 hasConcept C2780596555 @default.
- W4308010197 hasConcept C54355233 @default.
- W4308010197 hasConcept C71924100 @default.
- W4308010197 hasConcept C86803240 @default.
- W4308010197 hasConceptScore W4308010197C104317684 @default.
- W4308010197 hasConceptScore W4308010197C105702510 @default.
- W4308010197 hasConceptScore W4308010197C107459253 @default.
- W4308010197 hasConceptScore W4308010197C142724271 @default.
- W4308010197 hasConceptScore W4308010197C145103041 @default.
- W4308010197 hasConceptScore W4308010197C150194340 @default.
- W4308010197 hasConceptScore W4308010197C162317418 @default.
- W4308010197 hasConceptScore W4308010197C169760540 @default.
- W4308010197 hasConceptScore W4308010197C2779134260 @default.
- W4308010197 hasConceptScore W4308010197C2779959927 @default.
- W4308010197 hasConceptScore W4308010197C2780596555 @default.
- W4308010197 hasConceptScore W4308010197C54355233 @default.
- W4308010197 hasConceptScore W4308010197C71924100 @default.
- W4308010197 hasConceptScore W4308010197C86803240 @default.
- W4308010197 hasLocation W43080101971 @default.
- W4308010197 hasLocation W43080101972 @default.
- W4308010197 hasOpenAccess W4308010197 @default.
- W4308010197 hasPrimaryLocation W43080101971 @default.
- W4308010197 hasRelatedWork W1917568245 @default.
- W4308010197 hasRelatedWork W2009966535 @default.
- W4308010197 hasRelatedWork W2083356601 @default.
- W4308010197 hasRelatedWork W2101631778 @default.
- W4308010197 hasRelatedWork W2317226401 @default.
- W4308010197 hasRelatedWork W2769704507 @default.
- W4308010197 hasRelatedWork W3012091774 @default.
- W4308010197 hasRelatedWork W3199135772 @default.
- W4308010197 hasRelatedWork W4207037142 @default.
- W4308010197 hasRelatedWork W572960715 @default.
- W4308010197 isParatext "false" @default.
- W4308010197 isRetracted "false" @default.
- W4308010197 workType "article" @default.