FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308012145> ?p ?o ?g. }

• W4308012145 endingPage "59" @default.
• W4308012145 startingPage "54" @default.
• W4308012145 abstract "Objective: The present study aimed to evaluate of antimigraine activity of methanolic extract of Abroma augusta L. leaves in laboratory animals. Methods: The antimigraine activity was evaluated against nitroglycerine (NTG, 10 mg·kg−1, i. p.) and bradykinin (BK, 10 µg, intra-arterial) induced hyperalgesia in rats. Rats were divided randomly into six groups: normal, control, standard (sumatriptan, 42 mg·kg−1, s. c.), and Abroma augusta L. (100,200 and 400 mg·kg−1, p. o.). In the nitroglycerin (NTG) induced hyperalgesia model, rats were pre-treated with standard drug sumatriptan and Abroma augusta L. for 0, 7 and 14 d and tail flick latency were recorded separately in 0-day, 7-day and 14-day pretreatment study. Brain serotonin concentration was also estimated by HPLC method at the end of the study. In bradykinin induced hyperalgesia model the number of vocalizations were recorded as a measure of hyperalgesia in rats. Results: Abroma augusta L. showed a significant (P<0.001) elevation in the tail-flick latency (at dose 400 mg·kg−1) and body weight (at doses 100, 200, and 400 mg·kg−1) in NTG-induced hyperalgesia model in rats. Further, A. augusta L. (400 mg/kg) showed a significant (P<0.001) increase in brain serotonin concentration compared to NTG control group animal. It showed a significant (P<0.01, P<0.001) reduction in the elevated number of vocalizations at doses (200 and 400 mg·kg−1) in the bradykinin-induced hyperalgesia model in rats. Conclusion: We concluded that the methanolic extract of Aroma augusta L. possessed an anti-migraine effect in nitroglycerine and bradykinin-induced hyperalgesia model in rats." @default.
• W4308012145 created "2022-11-07" @default.
• W4308012145 creator A5018115341 @default.
• W4308012145 creator A5038980636 @default.
• W4308012145 date "2022-11-01" @default.
• W4308012145 modified "2023-09-26" @default.
• W4308012145 title "ANTIMIGRAINE ACTIVITY OF METHANOLIC EXTRACT OF ABROMA AUGUSTA L. IN LABORATORY ANIMALS" @default.
• W4308012145 cites W1973464565 @default.
• W4308012145 cites W1973742265 @default.
• W4308012145 cites W1975101207 @default.
• W4308012145 cites W1975952670 @default.
• W4308012145 cites W1979563617 @default.
• W4308012145 cites W1987527657 @default.
• W4308012145 cites W1987992465 @default.
• W4308012145 cites W1993987435 @default.
• W4308012145 cites W1994551290 @default.
• W4308012145 cites W1998999302 @default.
• W4308012145 cites W2013440527 @default.
• W4308012145 cites W2020385538 @default.
• W4308012145 cites W2022356113 @default.
• W4308012145 cites W2023039388 @default.
• W4308012145 cites W2033825789 @default.
• W4308012145 cites W2037374843 @default.
• W4308012145 cites W2047455969 @default.
• W4308012145 cites W2053892531 @default.
• W4308012145 cites W2065685736 @default.
• W4308012145 cites W2078596134 @default.
• W4308012145 cites W2086126627 @default.
• W4308012145 cites W2086453887 @default.
• W4308012145 cites W2091260251 @default.
• W4308012145 cites W2091270761 @default.
• W4308012145 cites W2094566631 @default.
• W4308012145 cites W2110621782 @default.
• W4308012145 cites W2133642963 @default.
• W4308012145 cites W2142397168 @default.
• W4308012145 cites W2155313713 @default.
• W4308012145 cites W2304871116 @default.
• W4308012145 cites W2306489483 @default.
• W4308012145 cites W2399750252 @default.
• W4308012145 cites W2406663808 @default.
• W4308012145 cites W2791168275 @default.
• W4308012145 doi "https://doi.org/10.22159/ijpps.2022v14i11.45810" @default.
• W4308012145 hasPublicationYear "2022" @default.
• W4308012145 type Work @default.
• W4308012145 citedByCount "0" @default.
• W4308012145 crossrefType "journal-article" @default.
• W4308012145 hasAuthorship W4308012145A5018115341 @default.
• W4308012145 hasAuthorship W4308012145A5038980636 @default.
• W4308012145 hasBestOaLocation W43080121451 @default.
• W4308012145 hasConcept C126322002 @default.
• W4308012145 hasConcept C15490471 @default.
• W4308012145 hasConcept C170493617 @default.
• W4308012145 hasConcept C185592680 @default.
• W4308012145 hasConcept C2775864247 @default.
• W4308012145 hasConcept C2778871607 @default.
• W4308012145 hasConcept C2778938600 @default.
• W4308012145 hasConcept C2779245659 @default.
• W4308012145 hasConcept C2779591629 @default.
• W4308012145 hasConcept C42219234 @default.
• W4308012145 hasConcept C71924100 @default.
• W4308012145 hasConcept C98274493 @default.
• W4308012145 hasConceptScore W4308012145C126322002 @default.
• W4308012145 hasConceptScore W4308012145C15490471 @default.
• W4308012145 hasConceptScore W4308012145C170493617 @default.
• W4308012145 hasConceptScore W4308012145C185592680 @default.
• W4308012145 hasConceptScore W4308012145C2775864247 @default.
• W4308012145 hasConceptScore W4308012145C2778871607 @default.
• W4308012145 hasConceptScore W4308012145C2778938600 @default.
• W4308012145 hasConceptScore W4308012145C2779245659 @default.
• W4308012145 hasConceptScore W4308012145C2779591629 @default.
• W4308012145 hasConceptScore W4308012145C42219234 @default.
• W4308012145 hasConceptScore W4308012145C71924100 @default.
• W4308012145 hasConceptScore W4308012145C98274493 @default.
• W4308012145 hasLocation W43080121451 @default.
• W4308012145 hasOpenAccess W4308012145 @default.
• W4308012145 hasPrimaryLocation W43080121451 @default.
• W4308012145 hasRelatedWork W2015060909 @default.
• W4308012145 hasRelatedWork W2025218189 @default.
• W4308012145 hasRelatedWork W2036693266 @default.
• W4308012145 hasRelatedWork W2044188934 @default.
• W4308012145 hasRelatedWork W2084868722 @default.
• W4308012145 hasRelatedWork W2091910916 @default.
• W4308012145 hasRelatedWork W2748952813 @default.
• W4308012145 hasRelatedWork W2899084033 @default.
• W4308012145 hasRelatedWork W4308012145 @default.
• W4308012145 hasRelatedWork W798824832 @default.
• W4308012145 isParatext "false" @default.
• W4308012145 isRetracted "false" @default.
• W4308012145 workType "article" @default.