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• W4308012329 abstract "Abstract Background Treatment of Cutaneous Leishmaniasis (CL) remains a major challenge for the public health and medical community. Natural compounds such as larval products of Lucilia sericata flies have Leishmanicidal effects against some species of Leishmania . The present study aimed at assessing the in vitro effects larval products against the promastigote and intracellular amastigote forms of Leishmania major . Also, the therapeutic effect of larval products on lesions induced by L. major infection was evaluated in BALB/c mice models. Methods The parasites and cells were treated with concentration of larval products ranging from 75-750ug/mL for 24-120h. Lesion progression and parasite load were investigated in the models for assessing the therapeutic effects of the products. Results The larval saliva and hemolymph showed highly cytotoxic effect against L. major promastigotes with IC 50 values of 100.6 and 37.96ug/mL, respectively compared to Glucantime with 9.480ug/mL. Also, the results indicated that the larval products of L. sericata had greater cytotoxic effects on the promastigotes of L. major than on the macrophage cells ( P < 0.05 ). Treatment with larval products decreased the infection rate and the number of amastigotes per host cell at all concentrations. The in vivo results showed a significantly ( p < 0.0001 ) smaller lesion size in the groups of treated mice compared with the untreated control group. The average parasite burden groups of treated mice (1.81 ± 0.74, 1.03 ± 0.45 and 3.37 ± 0.41) were significantly lower ( p = 0.0001 ) than untreated control group (6.72 ± 2.37), and was similar to the group treated with daily injection of Glucantime (1.77 ± 0.99). Conclusion The results suggested that L. sericata larval products are effective L. major in vivo and in vitro . However, more clinical trial studies are recommended to appraise the effects of these larval products in human subjects." @default.
• W4308012329 created "2022-11-07" @default.
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• W4308012329 date "2022-11-01" @default.
• W4308012329 modified "2023-10-17" @default.
• W4308012329 title "The therapeutic effect of larval saliva and hemolymph of Lucilia sericata on the treatment of Leishmania major lesion in BALB/c mice" @default.
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• W4308012329 doi "https://doi.org/10.21203/rs.3.rs-2209624/v1" @default.
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