Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308012981> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W4308012981 abstract "Abstract Background: Flow cytometry (FC) is an expensive investigation that is unaffordable for many patients from underprivileged nations. We aimed to reduce the total budget of the test by optimizing a limited antibody panel as guided by morphological assessment. Materials and methods: This single-center, the experimental study included 247 patients referred for Flow cytometry at Rehman Medical Institute, Peshawar.There were 162 male (65.4 %) and 85 female patients (34.6%) with a mean age of 38.78±21.55 years. Bone marrow or peripheral blood samples were used for immunophenotyping. After the morphological assessment, a limited panel of flow markers was selected. All samples were stained with fluorochromes labeled monoclonal antibodies, acquired, and analyzed with a flow cytometer (Cytoflex, BeckMan-Coulter, USA). Data were statistically analyzed through SPSS-22, and descriptive statistics were applied for all variables. All results were presented in form of graphs, tables, and charts Results: Out of 247 cases, an Acute leukemia panel was requested for 128 cases, a lymphoproliferative panel for 56 cases, T-cell subset analysis for 53 cases, and PNH clone screening for 10 cases. Newly diagnosed cases were 221 while 26 cases were known labeled cases of Acute leukemia for Minimal Residual Disease (MRD) analysis. Among the cases for MRD analysis, 10 cases were in remission, 12 cases relapsed and 04 cases were not in the remission phase. 98% of cases referred for Acute leukemia and Lymphoproliferative disorders, and 100% of cases referred for proximal nocturnal Hemoglobinuria (PNH) and T-cell subset analysis was conclusively diagnosed by our limited flow cytometry panels with low-cost effect. Conclusions: In resource-constrained settings, optimization of a limited antibody panel is extremely facilitating to provide a Flow cytometry-based diagnosis which further guides the treatment decision." @default.
- W4308012981 created "2022-11-07" @default.
- W4308012981 creator A5011921004 @default.
- W4308012981 creator A5012718293 @default.
- W4308012981 creator A5025070320 @default.
- W4308012981 creator A5030883549 @default.
- W4308012981 creator A5046442658 @default.
- W4308012981 creator A5067558273 @default.
- W4308012981 date "2022-11-01" @default.
- W4308012981 modified "2023-10-18" @default.
- W4308012981 title "Diagnostic utility of flow cytometry in resource-constrained settings- a single center experience" @default.
- W4308012981 cites W1990583153 @default.
- W4308012981 cites W2095901905 @default.
- W4308012981 cites W2101591778 @default.
- W4308012981 cites W2114575000 @default.
- W4308012981 cites W2277222786 @default.
- W4308012981 cites W2325454814 @default.
- W4308012981 cites W2328992047 @default.
- W4308012981 cites W2558502346 @default.
- W4308012981 cites W2782136952 @default.
- W4308012981 cites W2912041734 @default.
- W4308012981 cites W2947514480 @default.
- W4308012981 cites W2951210774 @default.
- W4308012981 cites W2984707601 @default.
- W4308012981 cites W2989482274 @default.
- W4308012981 cites W3001570485 @default.
- W4308012981 cites W3187031157 @default.
- W4308012981 cites W4237163879 @default.
- W4308012981 doi "https://doi.org/10.21203/rs.3.rs-2210472/v1" @default.
- W4308012981 hasPublicationYear "2022" @default.
- W4308012981 type Work @default.
- W4308012981 citedByCount "0" @default.
- W4308012981 crossrefType "posted-content" @default.
- W4308012981 hasAuthorship W4308012981A5011921004 @default.
- W4308012981 hasAuthorship W4308012981A5012718293 @default.
- W4308012981 hasAuthorship W4308012981A5025070320 @default.
- W4308012981 hasAuthorship W4308012981A5030883549 @default.
- W4308012981 hasAuthorship W4308012981A5046442658 @default.
- W4308012981 hasAuthorship W4308012981A5067558273 @default.
- W4308012981 hasBestOaLocation W43080129811 @default.
- W4308012981 hasConcept C126322002 @default.
- W4308012981 hasConcept C142724271 @default.
- W4308012981 hasConcept C196166836 @default.
- W4308012981 hasConcept C203014093 @default.
- W4308012981 hasConcept C2776863199 @default.
- W4308012981 hasConcept C2776995267 @default.
- W4308012981 hasConcept C2777346216 @default.
- W4308012981 hasConcept C2778461978 @default.
- W4308012981 hasConcept C2779338263 @default.
- W4308012981 hasConcept C2779823535 @default.
- W4308012981 hasConcept C2780007613 @default.
- W4308012981 hasConcept C2780073493 @default.
- W4308012981 hasConcept C2780339063 @default.
- W4308012981 hasConcept C54355233 @default.
- W4308012981 hasConcept C552990157 @default.
- W4308012981 hasConcept C553184892 @default.
- W4308012981 hasConcept C71924100 @default.
- W4308012981 hasConcept C81089528 @default.
- W4308012981 hasConcept C86803240 @default.
- W4308012981 hasConcept C90924648 @default.
- W4308012981 hasConceptScore W4308012981C126322002 @default.
- W4308012981 hasConceptScore W4308012981C142724271 @default.
- W4308012981 hasConceptScore W4308012981C196166836 @default.
- W4308012981 hasConceptScore W4308012981C203014093 @default.
- W4308012981 hasConceptScore W4308012981C2776863199 @default.
- W4308012981 hasConceptScore W4308012981C2776995267 @default.
- W4308012981 hasConceptScore W4308012981C2777346216 @default.
- W4308012981 hasConceptScore W4308012981C2778461978 @default.
- W4308012981 hasConceptScore W4308012981C2779338263 @default.
- W4308012981 hasConceptScore W4308012981C2779823535 @default.
- W4308012981 hasConceptScore W4308012981C2780007613 @default.
- W4308012981 hasConceptScore W4308012981C2780073493 @default.
- W4308012981 hasConceptScore W4308012981C2780339063 @default.
- W4308012981 hasConceptScore W4308012981C54355233 @default.
- W4308012981 hasConceptScore W4308012981C552990157 @default.
- W4308012981 hasConceptScore W4308012981C553184892 @default.
- W4308012981 hasConceptScore W4308012981C71924100 @default.
- W4308012981 hasConceptScore W4308012981C81089528 @default.
- W4308012981 hasConceptScore W4308012981C86803240 @default.
- W4308012981 hasConceptScore W4308012981C90924648 @default.
- W4308012981 hasLocation W43080129811 @default.
- W4308012981 hasOpenAccess W4308012981 @default.
- W4308012981 hasPrimaryLocation W43080129811 @default.
- W4308012981 hasRelatedWork W2002441913 @default.
- W4308012981 hasRelatedWork W2073832543 @default.
- W4308012981 hasRelatedWork W228239861 @default.
- W4308012981 hasRelatedWork W2359322268 @default.
- W4308012981 hasRelatedWork W2371673673 @default.
- W4308012981 hasRelatedWork W2377424070 @default.
- W4308012981 hasRelatedWork W3030951506 @default.
- W4308012981 hasRelatedWork W3141035211 @default.
- W4308012981 hasRelatedWork W4308012981 @default.
- W4308012981 hasRelatedWork W4313491894 @default.
- W4308012981 isParatext "false" @default.
- W4308012981 isRetracted "false" @default.
- W4308012981 workType "article" @default.