FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308015623> ?p ?o ?g. }

• W4308015623 abstract "Abstract Background Epidemiological studies have reported an association between amyotrophic lateral sclerosis (ALS) and different autoimmune disorders. This study aims to explore the causal relationship between autoimmune disorders and ALS using Mendelian randomization (MR). Methods To test the genetically predicted effects of liability towards immune-related outcomes on ALS risk, we used summary statistics from the largest European genome-wide association studies (GWAS) for these disorders in a two-sample MR setting. To do this, we extracted single nucleotide polymorphisms (SNPs) from the GWAS, which strongly associated with the 12 traits, and queried their effects in a large European ALS GWAS (27,265 cases and 110,881 controls). To avoid bias in our MR instruments related to the complex linkage disequilibrium structure of the human leukocyte antigen (HLA) region, we excluded SNPs within this region from the analyses. We computed inverse-variance weighted (IVW) MR estimates and undertook sensitivity analyses using MR methods robust to horizontal pleiotropy. We also performed a reverse MR analysis testing the causal effects of ALS on the above autoimmune traits. Results After applying Bonferroni correction for multiple testing, our MR analyses showed that the liability to autoimmune disorders does not affect ALS risk. Our reverse MR analysis also did not support the effects of liability to ALS on other autoimmune disorders. The results of the main IVW MR analyses were generally supported by our sensitivity MR analyses. The variance in the exposures explained by the sets of SNPs used as MR instruments ranged from 8.1 × 10 −4 to 0.31. Our MR study was well-powered to detect effects as small as an odds ratio (OR) of 1.045 for ALS in the main MR and as small as an OR of 1.32 in the reverse MR. Conclusion Our MR study does not support a relationship between liability to autoimmune disorders and ALS risk in the European population. The associations observed in epidemiological studies could be partly attributed to shared biology or environmental confounders." @default.
• W4308015623 created "2022-11-07" @default.
• W4308015623 creator A5002529713 @default.
• W4308015623 creator A5002628021 @default.
• W4308015623 creator A5041301339 @default.
• W4308015623 creator A5052174215 @default.
• W4308015623 creator A5053417689 @default.
• W4308015623 creator A5069000668 @default.
• W4308015623 creator A5076682951 @default.
• W4308015623 date "2022-11-02" @default.
• W4308015623 modified "2023-10-10" @default.
• W4308015623 title "Investigation of the causal relationship between ALS and autoimmune disorders: a Mendelian randomization study" @default.
• W4308015623 cites W1552106782 @default.
• W4308015623 cites W1905058580 @default.
• W4308015623 cites W1975705143 @default.
• W4308015623 cites W1979375317 @default.
• W4308015623 cites W1989590412 @default.
• W4308015623 cites W2023233358 @default.
• W4308015623 cites W2028097575 @default.
• W4308015623 cites W2040578796 @default.
• W4308015623 cites W2058742494 @default.
• W4308015623 cites W2095352962 @default.
• W4308015623 cites W2095685454 @default.
• W4308015623 cites W2102889851 @default.
• W4308015623 cites W2109899118 @default.
• W4308015623 cites W2113699335 @default.
• W4308015623 cites W2127768736 @default.
• W4308015623 cites W2128736149 @default.
• W4308015623 cites W2155221045 @default.
• W4308015623 cites W2155533485 @default.
• W4308015623 cites W2163749231 @default.
• W4308015623 cites W2167295920 @default.
• W4308015623 cites W2169283889 @default.
• W4308015623 cites W2324862792 @default.
• W4308015623 cites W2528302205 @default.
• W4308015623 cites W2556818673 @default.
• W4308015623 cites W2563442740 @default.
• W4308015623 cites W2571503386 @default.
• W4308015623 cites W2577452028 @default.
• W4308015623 cites W2608171249 @default.
• W4308015623 cites W2761403361 @default.
• W4308015623 cites W2770598799 @default.
• W4308015623 cites W2803072880 @default.
• W4308015623 cites W2805983714 @default.
• W4308015623 cites W2818417770 @default.
• W4308015623 cites W2891812515 @default.
• W4308015623 cites W2901303766 @default.
• W4308015623 cites W2953121869 @default.
• W4308015623 cites W2963484270 @default.
• W4308015623 cites W2981477552 @default.
• W4308015623 cites W2991007563 @default.
• W4308015623 cites W3003402082 @default.
• W4308015623 cites W3007476749 @default.
• W4308015623 cites W3128131872 @default.
• W4308015623 cites W3165249197 @default.
• W4308015623 cites W3172857299 @default.
• W4308015623 cites W3202518185 @default.
• W4308015623 cites W4206029180 @default.
• W4308015623 cites W4210703904 @default.
• W4308015623 cites W4226286160 @default.
• W4308015623 cites W4252979096 @default.
• W4308015623 cites W4253754191 @default.
• W4308015623 doi "https://doi.org/10.1186/s12916-022-02578-9" @default.
• W4308015623 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36320012" @default.
• W4308015623 hasPublicationYear "2022" @default.
• W4308015623 type Work @default.
• W4308015623 citedByCount "2" @default.
• W4308015623 countsByYear W43080156232023 @default.
• W4308015623 crossrefType "journal-article" @default.
• W4308015623 hasAuthorship W4308015623A5002529713 @default.
• W4308015623 hasAuthorship W4308015623A5002628021 @default.
• W4308015623 hasAuthorship W4308015623A5041301339 @default.
• W4308015623 hasAuthorship W4308015623A5052174215 @default.
• W4308015623 hasAuthorship W4308015623A5053417689 @default.
• W4308015623 hasAuthorship W4308015623A5069000668 @default.
• W4308015623 hasAuthorship W4308015623A5076682951 @default.
• W4308015623 hasBestOaLocation W43080156231 @default.
• W4308015623 hasConcept C104317684 @default.
• W4308015623 hasConcept C105795698 @default.
• W4308015623 hasConcept C106208931 @default.
• W4308015623 hasConcept C127716648 @default.
• W4308015623 hasConcept C127808970 @default.
• W4308015623 hasConcept C135763542 @default.
• W4308015623 hasConcept C147483822 @default.
• W4308015623 hasConcept C153209595 @default.
• W4308015623 hasConcept C183905921 @default.
• W4308015623 hasConcept C186413461 @default.
• W4308015623 hasConcept C188280979 @default.
• W4308015623 hasConcept C203014093 @default.
• W4308015623 hasConcept C26207810 @default.
• W4308015623 hasConcept C2779901538 @default.
• W4308015623 hasConcept C2910691881 @default.
• W4308015623 hasConcept C2993967602 @default.
• W4308015623 hasConcept C33923547 @default.
• W4308015623 hasConcept C35605836 @default.
• W4308015623 hasConcept C54355233 @default.
• W4308015623 hasConcept C71924100 @default.
• W4308015623 hasConcept C86803240 @default.
• W4308015623 hasConceptScore W4308015623C104317684 @default.
• W4308015623 hasConceptScore W4308015623C105795698 @default.

• next