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- W4308028084 abstract "Abstract T cell exhaustion develops in human immunodeficiency virus (HIV) infection due to chronic viral antigenic stimulation. This adaptive response primarily affects virus-specific CD8 + T cells, which may remain dysfunctional despite viral load-reducing antiretroviral therapy; however, abnormalities may also be evident in non-HIV-specific populations. Both could limit the efficacy of cell therapies against viral reservoirs. Here, we show that bulk (polyclonal) CD8 + T cells from people living with HIV (PLWH) express proposed markers of dysfunctional HIV-specific T cells at high levels yet form lytic immunological synapses (IS) and eliminate primary resting infected (HIV Gag lo ) CD4 + T cells, when redirected by potent bispecific T cell-retargeting molecules, Immune mobilising monoclonal T cell receptors (TCR) Against Virus (ImmTAV). While PLWH CD8 + T cells are functionally impaired when compared to CD8 + T cells from HIV-naïve donors, ImmTAV redirection enables them to eliminate Gag lo CD4 + T cells that are insensitive to autologous HIV-specific cytolytic T cells. ImmTAV molecules may therefore be able to target HIV reservoirs, which represent a major barrier to a cure." @default.
- W4308028084 created "2022-11-07" @default.
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- W4308028084 date "2022-11-01" @default.
- W4308028084 modified "2023-10-12" @default.
- W4308028084 title "Immune mobilising T cell receptors redirect polyclonal CD8+ T cells in chronic HIV infection to form immunological synapses" @default.
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- W4308028084 doi "https://doi.org/10.1038/s41598-022-23228-3" @default.
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- W4308028084 hasPublicationYear "2022" @default.
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