Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308037687> ?p ?o ?g. }
- W4308037687 endingPage "111585" @default.
- W4308037687 startingPage "111585" @default.
- W4308037687 abstract "Posttranscriptional RNA modifications by adenosine-to-inosine (A-to-I) editing are abundant in the brain, yet elucidating functional sites remains challenging. To bridge this gap, we investigate spatiotemporal and genetically regulated A-to-I editing sites across prenatal and postnatal stages of human brain development. More than 10,000 spatiotemporally regulated A-to-I sites were identified that occur predominately in 3' UTRs and introns, as well as 37 sites that recode amino acids in protein coding regions with precise changes in editing levels across development. Hyper-edited transcripts are also enriched in the aging brain and stabilize RNA secondary structures. These features are conserved in murine and non-human primate models of neurodevelopment. Finally, thousands of cis-editing quantitative trait loci (edQTLs) were identified with unique regulatory effects during prenatal and postnatal development. Collectively, this work offers a resolved atlas linking spatiotemporal variation in editing levels to genetic regulatory effects throughout distinct stages of brain maturation." @default.
- W4308037687 created "2022-11-07" @default.
- W4308037687 creator A5014727014 @default.
- W4308037687 creator A5016013607 @default.
- W4308037687 creator A5019826061 @default.
- W4308037687 creator A5021301519 @default.
- W4308037687 creator A5026436089 @default.
- W4308037687 creator A5036647389 @default.
- W4308037687 creator A5042915991 @default.
- W4308037687 creator A5046881277 @default.
- W4308037687 creator A5047185009 @default.
- W4308037687 creator A5049830131 @default.
- W4308037687 creator A5050904472 @default.
- W4308037687 creator A5052199001 @default.
- W4308037687 creator A5063422669 @default.
- W4308037687 creator A5069644457 @default.
- W4308037687 creator A5077476842 @default.
- W4308037687 creator A5084641514 @default.
- W4308037687 date "2022-11-01" @default.
- W4308037687 modified "2023-10-02" @default.
- W4308037687 title "Spatiotemporal and genetic regulation of A-to-I editing throughout human brain development" @default.
- W4308037687 cites W1552434751 @default.
- W4308037687 cites W1780209601 @default.
- W4308037687 cites W1855150869 @default.
- W4308037687 cites W1912692175 @default.
- W4308037687 cites W1966955323 @default.
- W4308037687 cites W1971019263 @default.
- W4308037687 cites W1984068087 @default.
- W4308037687 cites W1986923087 @default.
- W4308037687 cites W1997535872 @default.
- W4308037687 cites W2005259783 @default.
- W4308037687 cites W2009215595 @default.
- W4308037687 cites W2010691380 @default.
- W4308037687 cites W2012800815 @default.
- W4308037687 cites W2014327850 @default.
- W4308037687 cites W2023923807 @default.
- W4308037687 cites W2023962370 @default.
- W4308037687 cites W2031820172 @default.
- W4308037687 cites W2033385373 @default.
- W4308037687 cites W2034018159 @default.
- W4308037687 cites W2040839903 @default.
- W4308037687 cites W2041509376 @default.
- W4308037687 cites W2051084778 @default.
- W4308037687 cites W2056025481 @default.
- W4308037687 cites W2056573404 @default.
- W4308037687 cites W2058112421 @default.
- W4308037687 cites W2065466457 @default.
- W4308037687 cites W2067547076 @default.
- W4308037687 cites W2071598557 @default.
- W4308037687 cites W2080847523 @default.
- W4308037687 cites W2101357408 @default.
- W4308037687 cites W2103250001 @default.
- W4308037687 cites W2119824183 @default.
- W4308037687 cites W2124649657 @default.
- W4308037687 cites W2136221057 @default.
- W4308037687 cites W2138188450 @default.
- W4308037687 cites W2139852278 @default.
- W4308037687 cites W2146127418 @default.
- W4308037687 cites W2146323391 @default.
- W4308037687 cites W2146512944 @default.
- W4308037687 cites W2146922461 @default.
- W4308037687 cites W2149217126 @default.
- W4308037687 cites W2154349943 @default.
- W4308037687 cites W2154653170 @default.
- W4308037687 cites W2157958624 @default.
- W4308037687 cites W2162169386 @default.
- W4308037687 cites W2166229429 @default.
- W4308037687 cites W2166736284 @default.
- W4308037687 cites W2169456326 @default.
- W4308037687 cites W2170786603 @default.
- W4308037687 cites W2241686927 @default.
- W4308037687 cites W2280633723 @default.
- W4308037687 cites W2410887442 @default.
- W4308037687 cites W2470212121 @default.
- W4308037687 cites W2492077070 @default.
- W4308037687 cites W2510286488 @default.
- W4308037687 cites W2527311739 @default.
- W4308037687 cites W2737121642 @default.
- W4308037687 cites W2742124973 @default.
- W4308037687 cites W2762506271 @default.
- W4308037687 cites W2763937007 @default.
- W4308037687 cites W2765641908 @default.
- W4308037687 cites W2766586377 @default.
- W4308037687 cites W2767741749 @default.
- W4308037687 cites W2790599046 @default.
- W4308037687 cites W2796236298 @default.
- W4308037687 cites W2802815532 @default.
- W4308037687 cites W2804152737 @default.
- W4308037687 cites W2883573930 @default.
- W4308037687 cites W2887408891 @default.
- W4308037687 cites W2889790826 @default.
- W4308037687 cites W2891169704 @default.
- W4308037687 cites W2903689387 @default.
- W4308037687 cites W2905504964 @default.
- W4308037687 cites W2909194804 @default.
- W4308037687 cites W2914482125 @default.
- W4308037687 cites W2928449698 @default.
- W4308037687 cites W2948949781 @default.