Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308039420> ?p ?o ?g. }
- W4308039420 endingPage "213175" @default.
- W4308039420 startingPage "213175" @default.
- W4308039420 abstract "Skin wounds have been reported to increase the number of microbial colonies susceptible to infection. Treatments using oral antibiotics have been limited due to their toxicity and hydrophobic characteristics. In this study, we developed a formulation of chloramphenicol microparticles (CPL MPs), which was modified into chitosan hydrogel to increase treatment efficiency in targeting infections and creating an optimal environment to support the healing process. CPL MPs were prepared by a cross-linker stabilized method using whey protein (WPI) biopolymer, and the CPL MPs hydrogel was designed using chitosan biopolymer. Based on the result, CPL-loaded MPs showed desired physical and encapsulation characteristics. In the in vitro study, drug release of CPL MPs in simulated wound fluid represented approximately 99.40 ± 7.01 % of the system after 24 h. The antibacterial activity of CPL-loaded MPs formulation (MIC value 12.5 μg/mL, MBC 25 μg/mL) was effective as MIC concentration increased. Furthermore, the formulation of CPL MPs into hydrogel showed a better dermatokinetic profile compared to hydrogel with pure CPL. Interestingly, the antibacterial activity of the ex vivo infection model showed that Staphylococcus aureus activity decreased by up to 99.98 % after 24 h administration of CPL MPs hydrogel when compared to pure-CPL hydrogel and blank hydrogel. These studies have confirmed that incorporating CPL MPs into hydrogel can provide a promising approach to skin infection treatment." @default.
- W4308039420 created "2022-11-07" @default.
- W4308039420 creator A5002797443 @default.
- W4308039420 creator A5018764501 @default.
- W4308039420 creator A5024892874 @default.
- W4308039420 creator A5046304069 @default.
- W4308039420 creator A5071876776 @default.
- W4308039420 creator A5088282141 @default.
- W4308039420 date "2022-12-01" @default.
- W4308039420 modified "2023-10-14" @default.
- W4308039420 title "Development of chloramphenicol wound dressing protein-based microparticles in chitosan hydrogel system for improved effectiveness of dermal wound therapy" @default.
- W4308039420 cites W1772188244 @default.
- W4308039420 cites W1980461645 @default.
- W4308039420 cites W2020294648 @default.
- W4308039420 cites W2020404336 @default.
- W4308039420 cites W2024816950 @default.
- W4308039420 cites W2028349699 @default.
- W4308039420 cites W2028440673 @default.
- W4308039420 cites W2033609511 @default.
- W4308039420 cites W2039810958 @default.
- W4308039420 cites W2047894660 @default.
- W4308039420 cites W2054903874 @default.
- W4308039420 cites W2062600088 @default.
- W4308039420 cites W2065038940 @default.
- W4308039420 cites W2075640084 @default.
- W4308039420 cites W2076013209 @default.
- W4308039420 cites W2081202706 @default.
- W4308039420 cites W2084472693 @default.
- W4308039420 cites W2088739013 @default.
- W4308039420 cites W2104347910 @default.
- W4308039420 cites W2128145732 @default.
- W4308039420 cites W2147038478 @default.
- W4308039420 cites W2175047975 @default.
- W4308039420 cites W2195330118 @default.
- W4308039420 cites W2208496709 @default.
- W4308039420 cites W2223402274 @default.
- W4308039420 cites W2333799339 @default.
- W4308039420 cites W2344598639 @default.
- W4308039420 cites W2415836609 @default.
- W4308039420 cites W2525225058 @default.
- W4308039420 cites W2550659691 @default.
- W4308039420 cites W2566464127 @default.
- W4308039420 cites W2783839254 @default.
- W4308039420 cites W2797376858 @default.
- W4308039420 cites W2799661631 @default.
- W4308039420 cites W2902042188 @default.
- W4308039420 cites W2921110755 @default.
- W4308039420 cites W2948360456 @default.
- W4308039420 cites W2951662684 @default.
- W4308039420 cites W2968727489 @default.
- W4308039420 cites W2968786318 @default.
- W4308039420 cites W2974107084 @default.
- W4308039420 cites W2981630148 @default.
- W4308039420 cites W3000100734 @default.
- W4308039420 cites W3000469614 @default.
- W4308039420 cites W3009125054 @default.
- W4308039420 cites W3040824094 @default.
- W4308039420 cites W3043229277 @default.
- W4308039420 cites W3081401332 @default.
- W4308039420 cites W3083730418 @default.
- W4308039420 cites W3091589802 @default.
- W4308039420 cites W3113234239 @default.
- W4308039420 cites W3154506809 @default.
- W4308039420 cites W3190984626 @default.
- W4308039420 cites W3191636295 @default.
- W4308039420 cites W4200510292 @default.
- W4308039420 doi "https://doi.org/10.1016/j.bioadv.2022.213175" @default.
- W4308039420 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36368057" @default.
- W4308039420 hasPublicationYear "2022" @default.
- W4308039420 type Work @default.
- W4308039420 citedByCount "1" @default.
- W4308039420 countsByYear W43080394202023 @default.
- W4308039420 crossrefType "journal-article" @default.
- W4308039420 hasAuthorship W4308039420A5002797443 @default.
- W4308039420 hasAuthorship W4308039420A5018764501 @default.
- W4308039420 hasAuthorship W4308039420A5024892874 @default.
- W4308039420 hasAuthorship W4308039420A5046304069 @default.
- W4308039420 hasAuthorship W4308039420A5071876776 @default.
- W4308039420 hasAuthorship W4308039420A5088282141 @default.
- W4308039420 hasConcept C136229726 @default.
- W4308039420 hasConcept C141071460 @default.
- W4308039420 hasConcept C150903083 @default.
- W4308039420 hasConcept C159985019 @default.
- W4308039420 hasConcept C178790620 @default.
- W4308039420 hasConcept C185592680 @default.
- W4308039420 hasConcept C192562407 @default.
- W4308039420 hasConcept C207001950 @default.
- W4308039420 hasConcept C2778473333 @default.
- W4308039420 hasConcept C2778636629 @default.
- W4308039420 hasConcept C2779489039 @default.
- W4308039420 hasConcept C2779732960 @default.
- W4308039420 hasConcept C2780104969 @default.
- W4308039420 hasConcept C2780269544 @default.
- W4308039420 hasConcept C2993269979 @default.
- W4308039420 hasConcept C501593827 @default.
- W4308039420 hasConcept C521977710 @default.
- W4308039420 hasConcept C523546767 @default.
- W4308039420 hasConcept C54355233 @default.