Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308045323> ?p ?o ?g. }
- W4308045323 endingPage "109170" @default.
- W4308045323 startingPage "109170" @default.
- W4308045323 abstract "Juvenile idiopathic arthritis (JIA) is a multifactorial autoimmune disease mediated by both adaptive and innate immunity. The role of neutrophils in the pathogenesis of autoimmune diseases is well-established; however, in JIA they are still markedly understudied. Here, we explored the neutrophil features and role of platelet-neutrophil aggregates in JIA patients and assessed the effect of TNF inhibitor (TNFi) therapy. We provide evidence of dysbalanced neutrophil subsets in JIA patients, with a shift towards immature and suppressive subpopulations that lack the cell-adhesion molecules. Correspondingly, patient sera contained high amounts of neutrophil- and platelet-related products. Transcriptomic analysis revealed neutrophil degranulation as the most affected process by TNFi therapy, which was mirrored by the decrease in degranulation products in the patient sera. Toll-like receptors −4, −7, and − 8 signaling pathways are particularly hyperresponsive in patients, but are strongly suppressed by TNFi. Overall, our study demonstrates augmented neutrophil and platelet responses in JIA patients." @default.
- W4308045323 created "2022-11-07" @default.
- W4308045323 creator A5026708588 @default.
- W4308045323 creator A5045453114 @default.
- W4308045323 creator A5063053463 @default.
- W4308045323 creator A5069973361 @default.
- W4308045323 creator A5081069024 @default.
- W4308045323 creator A5087626636 @default.
- W4308045323 creator A5088005536 @default.
- W4308045323 date "2022-12-01" @default.
- W4308045323 modified "2023-09-30" @default.
- W4308045323 title "Immunomodulation of neutrophils and platelets by TNF blockage in patients with juvenile idiopathic arthritis" @default.
- W4308045323 cites W195866280 @default.
- W4308045323 cites W1991586357 @default.
- W4308045323 cites W1997839876 @default.
- W4308045323 cites W2004382335 @default.
- W4308045323 cites W2007493927 @default.
- W4308045323 cites W2019922403 @default.
- W4308045323 cites W2024714476 @default.
- W4308045323 cites W2031474938 @default.
- W4308045323 cites W2033753616 @default.
- W4308045323 cites W2069385366 @default.
- W4308045323 cites W2070050178 @default.
- W4308045323 cites W2082273479 @default.
- W4308045323 cites W2089442993 @default.
- W4308045323 cites W2097599737 @default.
- W4308045323 cites W2103703668 @default.
- W4308045323 cites W2126747080 @default.
- W4308045323 cites W2172191543 @default.
- W4308045323 cites W2254094172 @default.
- W4308045323 cites W2307247696 @default.
- W4308045323 cites W2317865868 @default.
- W4308045323 cites W2345356016 @default.
- W4308045323 cites W2533664315 @default.
- W4308045323 cites W2550206620 @default.
- W4308045323 cites W2614641079 @default.
- W4308045323 cites W2769853730 @default.
- W4308045323 cites W2775642644 @default.
- W4308045323 cites W2793685667 @default.
- W4308045323 cites W2902411448 @default.
- W4308045323 cites W2903217807 @default.
- W4308045323 cites W2904625821 @default.
- W4308045323 cites W2912087422 @default.
- W4308045323 cites W2923462844 @default.
- W4308045323 cites W2950067394 @default.
- W4308045323 cites W2954731619 @default.
- W4308045323 cites W2964207622 @default.
- W4308045323 cites W2991624040 @default.
- W4308045323 cites W3027571932 @default.
- W4308045323 cites W3107992831 @default.
- W4308045323 cites W3110112428 @default.
- W4308045323 cites W3145969289 @default.
- W4308045323 cites W3147851779 @default.
- W4308045323 cites W3159729619 @default.
- W4308045323 cites W4205522860 @default.
- W4308045323 cites W4205802447 @default.
- W4308045323 doi "https://doi.org/10.1016/j.clim.2022.109170" @default.
- W4308045323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36336331" @default.
- W4308045323 hasPublicationYear "2022" @default.
- W4308045323 type Work @default.
- W4308045323 citedByCount "2" @default.
- W4308045323 countsByYear W43080453232023 @default.
- W4308045323 crossrefType "journal-article" @default.
- W4308045323 hasAuthorship W4308045323A5026708588 @default.
- W4308045323 hasAuthorship W4308045323A5045453114 @default.
- W4308045323 hasAuthorship W4308045323A5063053463 @default.
- W4308045323 hasAuthorship W4308045323A5069973361 @default.
- W4308045323 hasAuthorship W4308045323A5081069024 @default.
- W4308045323 hasAuthorship W4308045323A5087626636 @default.
- W4308045323 hasAuthorship W4308045323A5088005536 @default.
- W4308045323 hasBestOaLocation W43080453231 @default.
- W4308045323 hasConcept C126322002 @default.
- W4308045323 hasConcept C134897094 @default.
- W4308045323 hasConcept C136449434 @default.
- W4308045323 hasConcept C170493617 @default.
- W4308045323 hasConcept C17991360 @default.
- W4308045323 hasConcept C203014093 @default.
- W4308045323 hasConcept C2776914184 @default.
- W4308045323 hasConcept C2777077863 @default.
- W4308045323 hasConcept C2777983669 @default.
- W4308045323 hasConcept C2780942790 @default.
- W4308045323 hasConcept C49802076 @default.
- W4308045323 hasConcept C71924100 @default.
- W4308045323 hasConcept C8891405 @default.
- W4308045323 hasConcept C89560881 @default.
- W4308045323 hasConceptScore W4308045323C126322002 @default.
- W4308045323 hasConceptScore W4308045323C134897094 @default.
- W4308045323 hasConceptScore W4308045323C136449434 @default.
- W4308045323 hasConceptScore W4308045323C170493617 @default.
- W4308045323 hasConceptScore W4308045323C17991360 @default.
- W4308045323 hasConceptScore W4308045323C203014093 @default.
- W4308045323 hasConceptScore W4308045323C2776914184 @default.
- W4308045323 hasConceptScore W4308045323C2777077863 @default.
- W4308045323 hasConceptScore W4308045323C2777983669 @default.
- W4308045323 hasConceptScore W4308045323C2780942790 @default.
- W4308045323 hasConceptScore W4308045323C49802076 @default.
- W4308045323 hasConceptScore W4308045323C71924100 @default.
- W4308045323 hasConceptScore W4308045323C8891405 @default.