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- W4308045338 endingPage "855" @default.
- W4308045338 startingPage "846" @default.
- W4308045338 abstract "The development of methods to derive induced pluripotent stem cells (iPSCs) has propelled stem cell research, and has the potential to revolutionize many areas of medicine, including cancer immunotherapy. These cells can be propagated limitlessly and can differentiate into nearly any specialized cell type. The ability to perform precise multigene engineering at the iPSC stage, generate master cell lines after clonal selection, and faithfully promote differentiation along natural killer (NK) cells and T-cell lineages is now leading to new opportunities for the administration of off-the-shelf cytotoxic lymphocytes with direct antigen targeting to treat patients with relapsed/refractory cancer. In this review, we highlight the recent progress in iPSC editing and guided differentiation in the development of NK- and T-cell products for immunotherapy. We also discuss some of the potential barriers that remain in unleashing the full potential of iPSC-derived cytotoxic effector cells in the adoptive transfer setting, and how some of these limitations may be overcome through gene editing." @default.
- W4308045338 created "2022-11-07" @default.
- W4308045338 creator A5023014242 @default.
- W4308045338 creator A5027151969 @default.
- W4308045338 creator A5039003411 @default.
- W4308045338 date "2023-02-23" @default.
- W4308045338 modified "2023-09-30" @default.
- W4308045338 title "Engineered and banked iPSCs for advanced NK- and T-cell immunotherapies" @default.
- W4308045338 cites W1487014009 @default.
- W4308045338 cites W1632369379 @default.
- W4308045338 cites W1922239585 @default.
- W4308045338 cites W1939360714 @default.
- W4308045338 cites W1966128754 @default.
- W4308045338 cites W1966240013 @default.
- W4308045338 cites W1970894097 @default.
- W4308045338 cites W1985981664 @default.
- W4308045338 cites W1986371962 @default.
- W4308045338 cites W1987774343 @default.
- W4308045338 cites W1990416052 @default.
- W4308045338 cites W1991494425 @default.
- W4308045338 cites W1991936258 @default.
- W4308045338 cites W1997656140 @default.
- W4308045338 cites W1998104632 @default.
- W4308045338 cites W2008315025 @default.
- W4308045338 cites W2010607826 @default.
- W4308045338 cites W2012012527 @default.
- W4308045338 cites W2015958044 @default.
- W4308045338 cites W2027160668 @default.
- W4308045338 cites W2035121417 @default.
- W4308045338 cites W2039648189 @default.
- W4308045338 cites W2049358079 @default.
- W4308045338 cites W2050302632 @default.
- W4308045338 cites W2052002403 @default.
- W4308045338 cites W2059229059 @default.
- W4308045338 cites W2062504594 @default.
- W4308045338 cites W2065751798 @default.
- W4308045338 cites W2073247934 @default.
- W4308045338 cites W2081047303 @default.
- W4308045338 cites W2085771245 @default.
- W4308045338 cites W2092166052 @default.
- W4308045338 cites W2093732800 @default.
- W4308045338 cites W2097050852 @default.
- W4308045338 cites W2097790514 @default.
- W4308045338 cites W2100761325 @default.
- W4308045338 cites W2101736621 @default.
- W4308045338 cites W2105361655 @default.
- W4308045338 cites W2106219879 @default.
- W4308045338 cites W2109427914 @default.
- W4308045338 cites W2109544983 @default.
- W4308045338 cites W2113802879 @default.
- W4308045338 cites W2114358743 @default.
- W4308045338 cites W2115228434 @default.
- W4308045338 cites W2116818706 @default.
- W4308045338 cites W2119695630 @default.
- W4308045338 cites W2125987139 @default.
- W4308045338 cites W2140457680 @default.
- W4308045338 cites W2141553969 @default.
- W4308045338 cites W2142046859 @default.
- W4308045338 cites W2153416566 @default.
- W4308045338 cites W2153712501 @default.
- W4308045338 cites W2159846996 @default.
- W4308045338 cites W2162377851 @default.
- W4308045338 cites W2163988610 @default.
- W4308045338 cites W2165813814 @default.
- W4308045338 cites W2168864499 @default.
- W4308045338 cites W2262576767 @default.
- W4308045338 cites W2322553446 @default.
- W4308045338 cites W2342423058 @default.
- W4308045338 cites W2401987785 @default.
- W4308045338 cites W2419600344 @default.
- W4308045338 cites W2550226908 @default.
- W4308045338 cites W2605463821 @default.
- W4308045338 cites W2608500349 @default.
- W4308045338 cites W2787621143 @default.
- W4308045338 cites W2791653000 @default.
- W4308045338 cites W2793644168 @default.
- W4308045338 cites W2811330283 @default.
- W4308045338 cites W2864786814 @default.
- W4308045338 cites W2900794929 @default.
- W4308045338 cites W2922288722 @default.
- W4308045338 cites W2943383470 @default.
- W4308045338 cites W2944128808 @default.
- W4308045338 cites W2988189351 @default.
- W4308045338 cites W2995447672 @default.
- W4308045338 cites W3009933121 @default.
- W4308045338 cites W3014106461 @default.
- W4308045338 cites W3034974614 @default.
- W4308045338 cites W3041276616 @default.
- W4308045338 cites W3097128992 @default.
- W4308045338 cites W3122702917 @default.
- W4308045338 cites W3131629568 @default.
- W4308045338 cites W3133850382 @default.
- W4308045338 cites W3160669634 @default.
- W4308045338 cites W3186790035 @default.
- W4308045338 cites W3195992586 @default.
- W4308045338 cites W3201853605 @default.
- W4308045338 cites W4220893211 @default.
- W4308045338 cites W4225726604 @default.