Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308045504> ?p ?o ?g. }
- W4308045504 endingPage "127" @default.
- W4308045504 startingPage "115" @default.
- W4308045504 abstract "Diabetic foot ulcer (DFU) is among the most frequent complications of diabetes and is associated with significant morbidity and mortality. Excessive neutrophil extracellular traps (NETs) delay wound healing in diabetic patients. Therefore, interventions targeting NET release need to be developed to effectively prevent NET-based wound healing impairment. Gasdermin D (GSDMD), a pore-forming protein acts as a central executioner of inflammatory cell death and can activate inflammasomes in neutrophils to release NETs. A precise understanding of the mechanism underlying NET-mediated delay in diabetic wound healing may be valuable in identifying potential therapeutic targets to improve clinical outcomes. In this study, we reported that neutrophils were more susceptible to NETosis in diabetic wound environments of patients with DFU. By in vitro experiments and using in vivo mouse models of diabetic wound healing (wide-type, Nlrp3-/-, Casp-1-/-, and Gsdmd-/- mice), we demonstrated that NLRP3/caspase-1/GSDMD pathway on activation controls NET release by neutrophils in diabetic wound tissue. Furthermore, inhibition of GSDMD with disulfiram or genic deletion of Gsdmd abrogated NET formation, thereby accelerating diabetic wound healing. Disulfiram could inhibit NETs-mediated diabetic foot ulcer healing impairment by suppressing the NLRP3/Caspase-1/GSDMD pathway. In summary, our findings uncover a novel therapeutic role of disulfiram in inhibiting NET formation, which is of considerable value in accelerating wound healing in patients with DFU." @default.
- W4308045504 created "2022-11-07" @default.
- W4308045504 creator A5001970688 @default.
- W4308045504 creator A5003547177 @default.
- W4308045504 creator A5011487190 @default.
- W4308045504 creator A5022126305 @default.
- W4308045504 creator A5032073558 @default.
- W4308045504 creator A5050311492 @default.
- W4308045504 creator A5066210914 @default.
- W4308045504 creator A5071418579 @default.
- W4308045504 creator A5083099706 @default.
- W4308045504 date "2023-04-01" @default.
- W4308045504 modified "2023-10-15" @default.
- W4308045504 title "Disulfiram accelerates diabetic foot ulcer healing by blocking NET formation via suppressing the NLRP3/Caspase-1/GSDMD pathway" @default.
- W4308045504 cites W1518370142 @default.
- W4308045504 cites W1864325817 @default.
- W4308045504 cites W1913879859 @default.
- W4308045504 cites W1969806743 @default.
- W4308045504 cites W2102221395 @default.
- W4308045504 cites W2104934425 @default.
- W4308045504 cites W2110231257 @default.
- W4308045504 cites W2120472250 @default.
- W4308045504 cites W2125366323 @default.
- W4308045504 cites W2135290187 @default.
- W4308045504 cites W2144190812 @default.
- W4308045504 cites W2145280222 @default.
- W4308045504 cites W2164304811 @default.
- W4308045504 cites W2166585891 @default.
- W4308045504 cites W2175794645 @default.
- W4308045504 cites W2254774777 @default.
- W4308045504 cites W2418822219 @default.
- W4308045504 cites W2478547083 @default.
- W4308045504 cites W2513097242 @default.
- W4308045504 cites W2753229994 @default.
- W4308045504 cites W2762816177 @default.
- W4308045504 cites W2775777510 @default.
- W4308045504 cites W2777665100 @default.
- W4308045504 cites W2789617183 @default.
- W4308045504 cites W2792307022 @default.
- W4308045504 cites W2888168693 @default.
- W4308045504 cites W2888725678 @default.
- W4308045504 cites W2897465515 @default.
- W4308045504 cites W2908752885 @default.
- W4308045504 cites W2912016163 @default.
- W4308045504 cites W2953897413 @default.
- W4308045504 cites W2969750300 @default.
- W4308045504 cites W2972817358 @default.
- W4308045504 cites W2991708020 @default.
- W4308045504 cites W3000146621 @default.
- W4308045504 cites W3010604501 @default.
- W4308045504 cites W3017862272 @default.
- W4308045504 cites W3018968275 @default.
- W4308045504 cites W3022981886 @default.
- W4308045504 cites W3033024816 @default.
- W4308045504 cites W3036907807 @default.
- W4308045504 cites W3059773150 @default.
- W4308045504 cites W3088048785 @default.
- W4308045504 cites W3165203800 @default.
- W4308045504 cites W3172752297 @default.
- W4308045504 cites W3196091337 @default.
- W4308045504 cites W3205653341 @default.
- W4308045504 cites W3216206476 @default.
- W4308045504 cites W4210850500 @default.
- W4308045504 cites W4220788086 @default.
- W4308045504 cites W4294053335 @default.
- W4308045504 doi "https://doi.org/10.1016/j.trsl.2022.10.008" @default.
- W4308045504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36336332" @default.
- W4308045504 hasPublicationYear "2023" @default.
- W4308045504 type Work @default.
- W4308045504 citedByCount "8" @default.
- W4308045504 countsByYear W43080455042023 @default.
- W4308045504 crossrefType "journal-article" @default.
- W4308045504 hasAuthorship W4308045504A5001970688 @default.
- W4308045504 hasAuthorship W4308045504A5003547177 @default.
- W4308045504 hasAuthorship W4308045504A5011487190 @default.
- W4308045504 hasAuthorship W4308045504A5022126305 @default.
- W4308045504 hasAuthorship W4308045504A5032073558 @default.
- W4308045504 hasAuthorship W4308045504A5050311492 @default.
- W4308045504 hasAuthorship W4308045504A5066210914 @default.
- W4308045504 hasAuthorship W4308045504A5071418579 @default.
- W4308045504 hasAuthorship W4308045504A5083099706 @default.
- W4308045504 hasConcept C134018914 @default.
- W4308045504 hasConcept C134897094 @default.
- W4308045504 hasConcept C150903083 @default.
- W4308045504 hasConcept C203014093 @default.
- W4308045504 hasConcept C207001950 @default.
- W4308045504 hasConcept C2776914184 @default.
- W4308045504 hasConcept C2777858829 @default.
- W4308045504 hasConcept C2778144972 @default.
- W4308045504 hasConcept C2778523461 @default.
- W4308045504 hasConcept C2780269544 @default.
- W4308045504 hasConcept C555293320 @default.
- W4308045504 hasConcept C71924100 @default.
- W4308045504 hasConcept C86803240 @default.
- W4308045504 hasConcept C98274493 @default.
- W4308045504 hasConceptScore W4308045504C134018914 @default.
- W4308045504 hasConceptScore W4308045504C134897094 @default.
- W4308045504 hasConceptScore W4308045504C150903083 @default.