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- W4308045643 endingPage "101031" @default.
- W4308045643 startingPage "101031" @default.
- W4308045643 abstract "Alternative splicing (AS) is an essential post-transcriptional regulation mechanism for sex differentiation and gonadal development, which has rarely been reported in marine invertebrates. Sea cucumber (Apostichopus japonicus) is an economically important marine benthic echinoderm with a potential XX/XY sex determination mechanism, whose molecular mechanism in the gonadal differentiation has not been clearly understood. In this study, we analyzed available RNA-seq datasets of male and female gonads to explore if AS mechanism exerts an essential function in sex differentiation and gonadal development of A. japonicus. In our results, a total of 20,338 AS events from 7219 alternatively spliced genes, and 189 sexually differential alternative splicing (DAS) events from 156 genes were identified in gonadal transcriptome of sea cucumber. Gene Ontology analysis indicated that these DAS genes were significantly enriched in spermatogenesis-related GO terms. Maximal Clique Centrality (MCC) was then applied for protein-protein interaction (PPI) analysis to search for protein interactions and hub DAS gene. Among all DAS genes, we identified 10 DAS genes closely related to spermatogenesis and (or) sperm motility and a hub gene dnah1. Thus, this study revealed that alternative isoforms were generated from certain genes in female and male gonads through alternative splicing, which may provide direct evidence that alternative splicing mechanisms participate in female and male gonads. These results suggested a novel perspective for explaining the molecular mechanisms underlying gonadal differentiation between male and female sea cucumbers." @default.
- W4308045643 created "2022-11-07" @default.
- W4308045643 creator A5007068246 @default.
- W4308045643 creator A5044723722 @default.
- W4308045643 creator A5075770155 @default.
- W4308045643 date "2023-03-01" @default.
- W4308045643 modified "2023-10-17" @default.
- W4308045643 title "Identification of sex-specific splicing via comparative transcriptome analysis of gonads from sea cucumber Apostichopus japonicus" @default.
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- W4308045643 doi "https://doi.org/10.1016/j.cbd.2022.101031" @default.
- W4308045643 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36371882" @default.