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• W4308055783 abstract "Accurate diagnosis of diseases located in deep tissues is always challenging. The always-on probe often leads to false-positive signals due to nonspecific interaction of nanoprobes. Thus, stimuli-responsive nanoprobes are highly desirable, which, however, require complicated surface modification so as to achieve trigger-induced signal changes. Here pH-triggered switchable magnetic resonance imaging (MRI) nanoprobes were constructed by coordination-driven self-assembly of monodispersed iron oxide nanoparticles (MIONPs) with simple amino acid derivatives, which displayed typical T2-weighted MRI features, yet, were turned into T1-weighted MRI under slightly acidic conditions at the tumor site. The dynamic assembly and disassembly properties of MIONPs afford T2/T1 switchable contrast imaging, enabling selective turn-on signals at the tumor site with high specificity." @default.
• W4308055783 created "2022-11-07" @default.
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• W4308055783 date "2022-11-03" @default.
• W4308055783 modified "2023-10-14" @default.
• W4308055783 title "Coordination-Driven Self-Assembly of Iron Oxide Nanoparticles for Tumor Microenvironment-Responsive Magnetic Resonance Imaging" @default.
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• W4308055783 doi "https://doi.org/10.1021/acs.analchem.2c01341" @default.
• W4308055783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36326828" @default.
• W4308055783 hasPublicationYear "2022" @default.
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