Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308057277> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W4308057277 endingPage "793" @default.
- W4308057277 startingPage "786" @default.
- W4308057277 abstract "Prednisolone, 6-mercaptopurine, and pyridostigmine bromide are co-administered together to treat a neuromuscular autoimmune disease called myasthenia gravis. Prednisolone and 6-mercaptopurine are immunosuppressant drugs. 6-Mercaptopurine is the active form of the pro-drug azathioprine. Pyridostigmine bromide is a cholinesterase enzyme inhibitor. Curently, green characteristics are taken into account by analysts when they develop new methods.The spectra of the three compounds and plasma are highly overlapped, so this study aims to remove this overlap and determine the three components quantitatively in raw powders and spiked human plasma using green methods.Two multivariate updated chemometric models called principle component analysis and partial least-squares were developed. Three greenness assessment tools: the eco-scale, the analytical greenness metric approach, and the green analytical method index, were used to evaluate the greenness behavior of the generated models.The two models were verified in accordance with Food and Drug Administration requirements, and the results were within acceptable limits. In addition they are relatively green in accordance with the abovementioned greenness evaluation tools.The developed models succeeded in determining the proposed drugs in their tertiary combinations and spiked human plasma with satisfactory precision, accuracy, and good greenness behavior.Two ecologically evaluated, multivariate spectrophotometric methods were developed for the determination of pyridostigmine bromide, 6-mercaptopurine, and prednisolone in spiked human plasma." @default.
- W4308057277 created "2022-11-07" @default.
- W4308057277 creator A5027917050 @default.
- W4308057277 creator A5035280551 @default.
- W4308057277 creator A5066483584 @default.
- W4308057277 creator A5067181644 @default.
- W4308057277 date "2022-11-02" @default.
- W4308057277 modified "2023-09-26" @default.
- W4308057277 title "Tailoring Two Chemometric Models for Determination of Three Neuromuscular Combined Medications and Application to Spiked Human Plasma" @default.
- W4308057277 cites W1534118383 @default.
- W4308057277 cites W18245770 @default.
- W4308057277 cites W1875703089 @default.
- W4308057277 cites W1983404333 @default.
- W4308057277 cites W1992700305 @default.
- W4308057277 cites W1996842820 @default.
- W4308057277 cites W2026014423 @default.
- W4308057277 cites W2026645643 @default.
- W4308057277 cites W2033437714 @default.
- W4308057277 cites W2045927965 @default.
- W4308057277 cites W2053199438 @default.
- W4308057277 cites W2053263709 @default.
- W4308057277 cites W2076330904 @default.
- W4308057277 cites W2088663309 @default.
- W4308057277 cites W2092194924 @default.
- W4308057277 cites W2112136816 @default.
- W4308057277 cites W2118778313 @default.
- W4308057277 cites W2121673718 @default.
- W4308057277 cites W2161300457 @default.
- W4308057277 cites W2161743415 @default.
- W4308057277 cites W2171603465 @default.
- W4308057277 cites W2332947047 @default.
- W4308057277 cites W2408315300 @default.
- W4308057277 cites W2781931056 @default.
- W4308057277 cites W3035028232 @default.
- W4308057277 cites W3118764624 @default.
- W4308057277 cites W4300565850 @default.
- W4308057277 doi "https://doi.org/10.1093/jaoacint/qsac139" @default.
- W4308057277 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36322814" @default.
- W4308057277 hasPublicationYear "2022" @default.
- W4308057277 type Work @default.
- W4308057277 citedByCount "1" @default.
- W4308057277 countsByYear W43080572772023 @default.
- W4308057277 crossrefType "journal-article" @default.
- W4308057277 hasAuthorship W4308057277A5027917050 @default.
- W4308057277 hasAuthorship W4308057277A5035280551 @default.
- W4308057277 hasAuthorship W4308057277A5066483584 @default.
- W4308057277 hasAuthorship W4308057277A5067181644 @default.
- W4308057277 hasConcept C126322002 @default.
- W4308057277 hasConcept C185592680 @default.
- W4308057277 hasConcept C2776715498 @default.
- W4308057277 hasConcept C2778105408 @default.
- W4308057277 hasConcept C2779901103 @default.
- W4308057277 hasConcept C2910532367 @default.
- W4308057277 hasConcept C3020134792 @default.
- W4308057277 hasConcept C31896038 @default.
- W4308057277 hasConcept C43617362 @default.
- W4308057277 hasConcept C71924100 @default.
- W4308057277 hasConcept C98274493 @default.
- W4308057277 hasConceptScore W4308057277C126322002 @default.
- W4308057277 hasConceptScore W4308057277C185592680 @default.
- W4308057277 hasConceptScore W4308057277C2776715498 @default.
- W4308057277 hasConceptScore W4308057277C2778105408 @default.
- W4308057277 hasConceptScore W4308057277C2779901103 @default.
- W4308057277 hasConceptScore W4308057277C2910532367 @default.
- W4308057277 hasConceptScore W4308057277C3020134792 @default.
- W4308057277 hasConceptScore W4308057277C31896038 @default.
- W4308057277 hasConceptScore W4308057277C43617362 @default.
- W4308057277 hasConceptScore W4308057277C71924100 @default.
- W4308057277 hasConceptScore W4308057277C98274493 @default.
- W4308057277 hasIssue "3" @default.
- W4308057277 hasLocation W43080572771 @default.
- W4308057277 hasLocation W43080572772 @default.
- W4308057277 hasOpenAccess W4308057277 @default.
- W4308057277 hasPrimaryLocation W43080572771 @default.
- W4308057277 hasRelatedWork W1974896664 @default.
- W4308057277 hasRelatedWork W1999758184 @default.
- W4308057277 hasRelatedWork W2013439224 @default.
- W4308057277 hasRelatedWork W2050771813 @default.
- W4308057277 hasRelatedWork W2099408098 @default.
- W4308057277 hasRelatedWork W2128576733 @default.
- W4308057277 hasRelatedWork W2504719267 @default.
- W4308057277 hasRelatedWork W2556930228 @default.
- W4308057277 hasRelatedWork W4308057277 @default.
- W4308057277 hasRelatedWork W82581883 @default.
- W4308057277 hasVolume "106" @default.
- W4308057277 isParatext "false" @default.
- W4308057277 isRetracted "false" @default.
- W4308057277 workType "article" @default.