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- W4308058341 abstract "Abstract Background To describe the clinical characteristics and treatment outcomes of secondary ocular adnexal lymphoma (OAL), and emphasise the impact of timely biopsy and systemic evaluation on the diagnosis and treatment. Methods The data of patients with secondary OAL in our hospital from January 2010 to June 2021 were retrospectively reviewed. Results A total of 54 patients (30 men and 24 women) were included in the study. The mean age at presentation was 60 years (median 62 years; range 37–83 years). The main symptoms included ocular mass (74%), periorbital swelling (43%), and proptosis (39%). The main histopathological types were mucosa‐associated lymphoid tissue lymphoma (30%), diffuse large B‐cell lymphoma (28%), and natural killer/T‐cell lymphoma (18%). In particular, three patients exhibited different pathological types of ocular lymphoma compared to previously diagnosed systemic lymphoma. The most common site of ocular and systemic involvement was the orbit (85%) and lymph nodes (56%), respectively, and 25 (46%) patients had occult extraocular lesions. Additionally, the 5‐year overall survival rate of the entire cohort was 56%, and significant differences were observed between the three main pathological types and stages of the disease (all p < 0.001). Conclusions Secondary OAL is a rare disease with a poor prognosis. That the disease is associated with a more aggressive pathological type is well established, indolent lymphoma is not uncommon. Furthermore, OAL and previously diagnosed systemic lymphoma may be pathologically distinct in some patients. Therefore, we recommend a prompt excision biopsy and a thorough systemic evaluation of patients with suspected OAL." @default.
- W4308058341 created "2022-11-07" @default.
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- W4308058341 date "2022-11-18" @default.
- W4308058341 modified "2023-10-12" @default.
- W4308058341 title "Clinical characteristics and treatment outcomes of secondary ocular adnexal lymphoma" @default.
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- W4308058341 doi "https://doi.org/10.1111/ceo.14189" @default.
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