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- W4308061036 abstract "The total synthesis of alcyonolide, an antitumor xenicn diterpenoid, has been achieved. The inverse electron demand hetero-Diels–Alder reaction using a dienophile possessing an electron-withdrawing group provided the endo adduct which included a condensed lactone and dihydropyran rings with the desired three stereogenic centers. After introduction of the side chain by the Negishi coupling, the lactone ring was opened to form a Weinreb amide. The sequential transformation including conversion of Weinreb amide to aldehyde, PMB to acetate, and allylation of the aldehyde gave a mixture of separable four diastereomers. The desired stereoisomer was submitted to the 2,2,6,6-tetramethylpiperidine 1-oxyl oxidation, which afforded the δ-lactone and the methyl ketone side chain. Finally, the olefin metathesis of the desired isomer gave racemic alcyonolide." @default.
- W4308061036 created "2022-11-07" @default.
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- W4308061036 date "2022-11-03" @default.
- W4308061036 modified "2023-09-24" @default.
- W4308061036 title "Total Synthesis of Alcyonolide" @default.
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- W4308061036 doi "https://doi.org/10.1021/acs.joc.2c02031" @default.
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