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• W4308061193 endingPage "1974" @default.
• W4308061193 startingPage "1957" @default.
• W4308061193 abstract "Introduction There is a bi-directional link between type 2 diabetes mellitus (T2DM) and heart failure (HF) and their co-existence markedly increases an individual’s morbidity and mortality. Therefore, it is of major importance to diagnose early (and, even better, prevent) HF in T2DM patients, as well as adequately treat T2DM patients with HF.Areas covered The present narrative review discusses the effects of different antidiabetic drugs [metformin, pioglitazone, sulphonylureas (SUs), dipeptidyl peptidase 4 inhibitors (DPP4i), glucagon-like peptide-1 receptor agonists (GLP-1 RAs), sodium-glucose cotransporter 2 inhibitors (SGLT2i) and insulin] on HF incidence, hospitalization and outcomes. Current guidelines of diabetes and cardiology societies on this issue are also commented on.Expert opinion Metformin (+lifestyle interventions) is the first-line treatment for all T2DM patients and SGLT2i are the preferred drugs (class I, level of evidence A) in patients with T2DM and HF. Pioglitazone is contraindicated in HF, whereas SUs, DPP4i, GLP-1 RAs and insulin are considered as neutral. However, SUs may cause hypoglycemia and weight gain, saxagliptin (a DPP4i) must be avoided in this setting and GLP-1 RAs seem not to affect HF risk. There is an urgent need of increasing guidelines implementation regarding SGLT2i use in clinical practice, to sufficiently tackle the HF burden in T2DM." @default.
• W4308061193 created "2022-11-07" @default.
• W4308061193 creator A5010061478 @default.
• W4308061193 creator A5042594415 @default.
• W4308061193 creator A5058321397 @default.
• W4308061193 date "2022-11-20" @default.
• W4308061193 modified "2023-09-28" @default.
• W4308061193 title "Contemporary choice of glucose lowering agents in heart failure patients with type 2 diabetes" @default.
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