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- W4308062012 abstract "Aberrant DNA replication is the main source of genomic instability that leads to tumorigenesis and progression. MCM2, a core subunit of eukaryotic helicase, plays a vital role in DNA replication. The dysfunction of MCM2 results in the occurrence and progression of multiple cancers through impairing DNA replication and cell proliferation.MCM2 is a vital regulator in DNA replication. The overexpression of MCM2 was detected in multiple types of cancers, and the dysfunction of MCM2 was correlated with the progression and poor prognoses of malignant tumors. According to the altered expression of MCM2 and its correlation with clinicopathological features of cancer patients, MCM2 was thought to be a sensitive biomarker for cancer diagnosis, prognosis, and chemotherapy response. The anti-tumor effect induced by MCM2 inhibition implies the potential of MCM2 to be a novel therapeutic target for cancer treatment. Since DNA replication stress, which may stimulate anti-tumor immunity, frequently occurs in MCM2 deficient cells, it also proposes the possibility that MCM2 targeting improves the effect of tumor immunotherapy." @default.
- W4308062012 created "2022-11-07" @default.
- W4308062012 creator A5038386460 @default.
- W4308062012 creator A5042407103 @default.
- W4308062012 creator A5072135248 @default.
- W4308062012 date "2022-10-27" @default.
- W4308062012 modified "2023-10-14" @default.
- W4308062012 title "MCM2 in human cancer: functions, mechanisms, and clinical significance" @default.
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