Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308063241> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W4308063241 abstract "Abstract Background Sodium-glucose cotransporter 2 inhibitors reduce cardiovascular mortality in patients. We studied the effect of canagliflozin on cardiac remodeling and myocardial metabolism in a rat model of heart failure with preserved ejection fraction (HFpEF). Methods In this study, a rat model of HFpEF was treated with canagliflozin, and blood glucose, renal function, oxidative stress indexes, lipid parameters, biochemical indexes and echocardiographic left ventricular function were assessed in the normal control group (group A), heart failure group (group B) and treatment group (group C). Metabolomics was used to analyze the possible pathways involved in the activity of canagliflozin. Results After canagliflozin treatment, E/A significantly increased, the myocardial volume decreased, the fibrotic area decreased, and cardiac remodeling improved in the rats with HFpEF. Rats with HFpEF displayed higher levels of L-lysine, D-glucose, uridine, O-phosphoethanolamine, L-norleucine, ribothymidine, and UDP-N-acetyl-alpha-D-galactosamine, reflecting hypermetabolism, and these increases were reversed by canagliflozin treatment. Myocardial metabolomics analysis of HFpEF rats compared with normal controls showed enrichment of metabolites involved in β-alanine metabolism, pyrimidine metabolism, arginine metabolism, proline metabolism, the citrate cycle (TCA cycle), glycolysis or gluconeogenesis and pyruvate metabolism. Canagliflozin decreased starch and galactose metabolism; cysteine and methionine metabolism; phenylalanine, tyrosine and tryptophan biosynthesis; and phenylalanine metabolism pathway activity and improved energy metabolism. Conclusions Canagliflozin had a cardioprotective effect in rats with HFpEF." @default.
- W4308063241 created "2022-11-07" @default.
- W4308063241 creator A5003642180 @default.
- W4308063241 creator A5007410863 @default.
- W4308063241 creator A5008008825 @default.
- W4308063241 creator A5015042324 @default.
- W4308063241 creator A5036499113 @default.
- W4308063241 creator A5046452161 @default.
- W4308063241 creator A5059603277 @default.
- W4308063241 creator A5062826296 @default.
- W4308063241 creator A5088142461 @default.
- W4308063241 date "2022-11-03" @default.
- W4308063241 modified "2023-10-17" @default.
- W4308063241 title "Metabolomic analysis of the effect of canagliflozin on HFpEF rats and its underlying mechanism" @default.
- W4308063241 cites W2025266397 @default.
- W4308063241 cites W2039764145 @default.
- W4308063241 cites W2041205525 @default.
- W4308063241 cites W2146264128 @default.
- W4308063241 cites W2257723432 @default.
- W4308063241 cites W2424539745 @default.
- W4308063241 cites W2572506333 @default.
- W4308063241 cites W2626446274 @default.
- W4308063241 cites W2654143839 @default.
- W4308063241 cites W2745942654 @default.
- W4308063241 cites W2746903407 @default.
- W4308063241 cites W2764144227 @default.
- W4308063241 cites W2790864824 @default.
- W4308063241 cites W2884101530 @default.
- W4308063241 cites W2900413769 @default.
- W4308063241 cites W2913619273 @default.
- W4308063241 cites W2935805363 @default.
- W4308063241 cites W2980072629 @default.
- W4308063241 cites W2996492475 @default.
- W4308063241 cites W3008139277 @default.
- W4308063241 cites W3046483114 @default.
- W4308063241 cites W3082399975 @default.
- W4308063241 cites W3120249811 @default.
- W4308063241 cites W3132494856 @default.
- W4308063241 cites W3179896107 @default.
- W4308063241 cites W4255739262 @default.
- W4308063241 doi "https://doi.org/10.21203/rs.3.rs-1886973/v1" @default.
- W4308063241 hasPublicationYear "2022" @default.
- W4308063241 type Work @default.
- W4308063241 citedByCount "0" @default.
- W4308063241 crossrefType "posted-content" @default.
- W4308063241 hasAuthorship W4308063241A5003642180 @default.
- W4308063241 hasAuthorship W4308063241A5007410863 @default.
- W4308063241 hasAuthorship W4308063241A5008008825 @default.
- W4308063241 hasAuthorship W4308063241A5015042324 @default.
- W4308063241 hasAuthorship W4308063241A5036499113 @default.
- W4308063241 hasAuthorship W4308063241A5046452161 @default.
- W4308063241 hasAuthorship W4308063241A5059603277 @default.
- W4308063241 hasAuthorship W4308063241A5062826296 @default.
- W4308063241 hasAuthorship W4308063241A5088142461 @default.
- W4308063241 hasBestOaLocation W43080632411 @default.
- W4308063241 hasConcept C111566952 @default.
- W4308063241 hasConcept C126322002 @default.
- W4308063241 hasConcept C134018914 @default.
- W4308063241 hasConcept C135870905 @default.
- W4308063241 hasConcept C185592680 @default.
- W4308063241 hasConcept C20904676 @default.
- W4308063241 hasConcept C2777180221 @default.
- W4308063241 hasConcept C2777451236 @default.
- W4308063241 hasConcept C2777477808 @default.
- W4308063241 hasConcept C2778198053 @default.
- W4308063241 hasConcept C555293320 @default.
- W4308063241 hasConcept C62231903 @default.
- W4308063241 hasConcept C71924100 @default.
- W4308063241 hasConcept C98274493 @default.
- W4308063241 hasConceptScore W4308063241C111566952 @default.
- W4308063241 hasConceptScore W4308063241C126322002 @default.
- W4308063241 hasConceptScore W4308063241C134018914 @default.
- W4308063241 hasConceptScore W4308063241C135870905 @default.
- W4308063241 hasConceptScore W4308063241C185592680 @default.
- W4308063241 hasConceptScore W4308063241C20904676 @default.
- W4308063241 hasConceptScore W4308063241C2777180221 @default.
- W4308063241 hasConceptScore W4308063241C2777451236 @default.
- W4308063241 hasConceptScore W4308063241C2777477808 @default.
- W4308063241 hasConceptScore W4308063241C2778198053 @default.
- W4308063241 hasConceptScore W4308063241C555293320 @default.
- W4308063241 hasConceptScore W4308063241C62231903 @default.
- W4308063241 hasConceptScore W4308063241C71924100 @default.
- W4308063241 hasConceptScore W4308063241C98274493 @default.
- W4308063241 hasLocation W43080632411 @default.
- W4308063241 hasOpenAccess W4308063241 @default.
- W4308063241 hasPrimaryLocation W43080632411 @default.
- W4308063241 hasRelatedWork W2000010456 @default.
- W4308063241 hasRelatedWork W2019806229 @default.
- W4308063241 hasRelatedWork W2025645904 @default.
- W4308063241 hasRelatedWork W2064940611 @default.
- W4308063241 hasRelatedWork W2091844621 @default.
- W4308063241 hasRelatedWork W2156093747 @default.
- W4308063241 hasRelatedWork W2464596983 @default.
- W4308063241 hasRelatedWork W2748952813 @default.
- W4308063241 hasRelatedWork W2963017100 @default.
- W4308063241 hasRelatedWork W4246710695 @default.
- W4308063241 isParatext "false" @default.
- W4308063241 isRetracted "false" @default.
- W4308063241 workType "article" @default.