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- W4308100565 endingPage "102492" @default.
- W4308100565 startingPage "102492" @default.
- W4308100565 abstract "Eukaryotic DNA is packaged into nucleosomes, which further condenses into chromosomes. The telomeres, which form the protective end-capping of chromosomes, play a pivotal role in ageing and cancer. Recently, significant advances have been made in understanding the nucleosomal and telomeric chromatin structure at the molecular level. In addition, recent studies shed light on the nucleosomal organisation at telomeres revealing its ultrastructural organisation, the atomic structure at the nucleosome level, its dynamic properties, and higher-order packaging of telomeric chromatin. Considerable advances have furthermore been made in understanding the structure, function and organisation of shelterin, telomerase and CST complexes. Here we discuss these recent advances in the organisation of telomeric nucleosomes and chromatin and highlight progress in the structural understanding of shelterin, telomerase and CST complexes." @default.
- W4308100565 created "2022-11-08" @default.
- W4308100565 creator A5001849365 @default.
- W4308100565 creator A5002711994 @default.
- W4308100565 creator A5036968132 @default.
- W4308100565 date "2022-12-01" @default.
- W4308100565 modified "2023-10-14" @default.
- W4308100565 title "Telomeric chromatin structure" @default.
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- W4308100565 doi "https://doi.org/10.1016/j.sbi.2022.102492" @default.
- W4308100565 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36335846" @default.
- W4308100565 hasPublicationYear "2022" @default.