Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308102582> ?p ?o ?g. }
- W4308102582 abstract "Reduction and oxidation reactions are essential for biochemical processes. They are part of metabolic pathways and signal transduction. Reactive oxygen species (ROS) as second messengers and oxidative modifications of cysteinyl (Cys) residues are key to transduce and translate intracellular and intercellular signals. Dysregulation of cellular redox signaling is known as oxidative distress, which has been linked to various pathologies, including neurodegeneration. Alzheimer's disease (AD) is a neurodegenerative pathology linked to both, abnormal amyloid precursor protein (APP) processing, generating Aβ peptide, and Tau hyperphosphorylation and aggregation. Signs of oxidative distress in AD include: increase of ROS (H 2 O 2 , O 2 •− ), decrease of the levels or activities of antioxidant enzymes, abnormal oxidation of macromolecules related to elevated Aβ production, and changes in mitochondrial homeostasis linked to Tau phosphorylation. Interestingly, Cys residues present in APP form disulfide bonds that are important for intermolecular interactions and might be involved in the aggregation of Aβ. Moreover, two Cys residues in some Tau isoforms have been shown to be essential for Tau stabilization and its interaction with microtubules. Future research will show the complexities of Tau, its interactome, and the role that Cys residues play in the progression of AD. The specific modification of cysteinyl residues in redox signaling is also tightly connected to the regulation of various metabolic pathways. Many of these pathways have been found to be altered in AD, even at very early stages. In order to analyze the complex changes and underlying mechanisms, several AD models have been developed, including animal models, 2D and 3D cell culture, and ex-vivo studies of patient samples. The use of these models along with innovative, new redox analysis techniques are key to further understand the importance of the redox component in Alzheimer's disease and the identification of new therapeutic targets in the future." @default.
- W4308102582 created "2022-11-08" @default.
- W4308102582 creator A5025319223 @default.
- W4308102582 creator A5078774136 @default.
- W4308102582 creator A5089939752 @default.
- W4308102582 date "2022-11-03" @default.
- W4308102582 modified "2023-10-05" @default.
- W4308102582 title "Redox signaling and metabolism in Alzheimer's disease" @default.
- W4308102582 cites W1145544071 @default.
- W4308102582 cites W120058826 @default.
- W4308102582 cites W1423566601 @default.
- W4308102582 cites W1493499695 @default.
- W4308102582 cites W1542215809 @default.
- W4308102582 cites W1562901370 @default.
- W4308102582 cites W1607181948 @default.
- W4308102582 cites W1804731458 @default.
- W4308102582 cites W1955466454 @default.
- W4308102582 cites W1964476920 @default.
- W4308102582 cites W1967203590 @default.
- W4308102582 cites W1967355893 @default.
- W4308102582 cites W1968362444 @default.
- W4308102582 cites W1970259736 @default.
- W4308102582 cites W1972306266 @default.
- W4308102582 cites W1973923802 @default.
- W4308102582 cites W1974643117 @default.
- W4308102582 cites W1975287242 @default.
- W4308102582 cites W1977390472 @default.
- W4308102582 cites W1977635041 @default.
- W4308102582 cites W1980709154 @default.
- W4308102582 cites W1983523416 @default.
- W4308102582 cites W1983937216 @default.
- W4308102582 cites W1985855558 @default.
- W4308102582 cites W1986783906 @default.
- W4308102582 cites W1989167108 @default.
- W4308102582 cites W1989861729 @default.
- W4308102582 cites W1990293508 @default.
- W4308102582 cites W1990653561 @default.
- W4308102582 cites W1997684038 @default.
- W4308102582 cites W1999749739 @default.
- W4308102582 cites W2000309456 @default.
- W4308102582 cites W2006059120 @default.
- W4308102582 cites W2010390315 @default.
- W4308102582 cites W2011124873 @default.
- W4308102582 cites W2014843089 @default.
- W4308102582 cites W2017879322 @default.
- W4308102582 cites W2021654785 @default.
- W4308102582 cites W2027122806 @default.
- W4308102582 cites W2027250745 @default.
- W4308102582 cites W2029342214 @default.
- W4308102582 cites W2031880534 @default.
- W4308102582 cites W2033017137 @default.
- W4308102582 cites W2036911946 @default.
- W4308102582 cites W2039098481 @default.
- W4308102582 cites W2040258716 @default.
- W4308102582 cites W2040710063 @default.
- W4308102582 cites W2041265105 @default.
- W4308102582 cites W2046826354 @default.
- W4308102582 cites W2047428823 @default.
- W4308102582 cites W2048718653 @default.
- W4308102582 cites W2049081132 @default.
- W4308102582 cites W2049660003 @default.
- W4308102582 cites W2049796821 @default.
- W4308102582 cites W2050054515 @default.
- W4308102582 cites W2050860441 @default.
- W4308102582 cites W2052020575 @default.
- W4308102582 cites W2056357865 @default.
- W4308102582 cites W2057714820 @default.
- W4308102582 cites W2059700478 @default.
- W4308102582 cites W2062643218 @default.
- W4308102582 cites W2062893281 @default.
- W4308102582 cites W2063886117 @default.
- W4308102582 cites W2064248739 @default.
- W4308102582 cites W2064736886 @default.
- W4308102582 cites W2066223581 @default.
- W4308102582 cites W2066551411 @default.
- W4308102582 cites W2068826328 @default.
- W4308102582 cites W2069862107 @default.
- W4308102582 cites W2072329091 @default.
- W4308102582 cites W2075563207 @default.
- W4308102582 cites W2077905824 @default.
- W4308102582 cites W2083211943 @default.
- W4308102582 cites W2089141103 @default.
- W4308102582 cites W2089818796 @default.
- W4308102582 cites W2089855345 @default.
- W4308102582 cites W2089926295 @default.
- W4308102582 cites W2090013938 @default.
- W4308102582 cites W2091293475 @default.
- W4308102582 cites W2092613198 @default.
- W4308102582 cites W2094652904 @default.
- W4308102582 cites W2094869059 @default.
- W4308102582 cites W2095563693 @default.
- W4308102582 cites W2098548022 @default.
- W4308102582 cites W2098815154 @default.
- W4308102582 cites W2102117809 @default.
- W4308102582 cites W2105442740 @default.
- W4308102582 cites W2108386295 @default.
- W4308102582 cites W2109977411 @default.
- W4308102582 cites W2118040247 @default.
- W4308102582 cites W2120162345 @default.
- W4308102582 cites W2122056834 @default.