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- W4308103428 endingPage "382" @default.
- W4308103428 startingPage "369" @default.
- W4308103428 abstract "Microglia may only represent 10% of central nervous system (CNS) cells but they perform critical roles in development, homeostasis and neurological disease. Microglia are also environmentally regulated, quickly losing their transcriptomic and epigenetic signature after leaving the CNS. This facet of microglia biology is both fascinating and technically challenging influencing the study of the genetics and function of human microglia in a manner that recapitulates the CNS environment. In this review we provide a comprehensive overview of existing in vitro and in vivo methodology to study human microglia, such as immortalized cells lines, stem cell-derived microglia, cerebral organoids and xenotransplantation. Since there is currently no single method that completely recapitulates all hallmarks of human ex vivo adult homeostatic microglia, we also discuss the advantages and limitations of each existing model as a practical guide for researchers." @default.
- W4308103428 created "2022-11-08" @default.
- W4308103428 creator A5005389452 @default.
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- W4308103428 creator A5075983274 @default.
- W4308103428 creator A5085761795 @default.
- W4308103428 date "2023-01-01" @default.
- W4308103428 modified "2023-09-26" @default.
- W4308103428 title "Tools for studying human microglia: In vitro and in vivo strategies" @default.
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