Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308105901> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W4308105901 abstract "Rapid recovery of blocked coronary artery blood flow after myocardial infarction (MI) is the key to reducing the size of the infarcted area, improving clinical outcome and decreasing mortality. However, ischemia/reperfusion (I/R) injury has a complicated pathological mechanism and is an inevitable complication of coronary artery blood flow recovery. Growth arrest and DNA damage‑inducible α (GADD45A) serves a vital role in myocardial injury induced by I/R. The present study aimed to explore the role and mechanisms of GADD45A in cardiac microvascular endothelial cells (CMEC)‑I/R injury in vivo and in vitro. An I/R injury rat model and a hypoxia/reoxygenation (H/R) cellular model were established, and myocardial tissues were collected for GADD45A detection, 2,3,5‑triphenyltetrazolium chloride staining, H&E staining, and dual staining of CD31 and TUNEL. Serum was also collected for the analysis of creatine kinase and lactate dehydrogenase in I/R rats following GADD45A silencing. Additionally, the protein expression levels of CD31, phosphorylated‑endothelial nitric oxide synthase (p‑eNOS), endothelin‑1 (ET‑1), JNK, p38 MAPK, STAT3 and VEGF were assessed by western blotting. The JNK and p38 MAPK activator, anisomycin, and the JAK2‑STAT3 pathway inhibitor, AG490, were used to determine the involvement of JNK/p38 MAPK pathway and STAT3/VEGF pathway. GADD45A was highly expressed in I/R injury rat and cell models. GADD45A silencing reduced the ischemic area and improved myocardial pathological damage in vivo. Furthermore, the levels of CD31 and p‑eNOS were increased, whereas ET‑1 was decreased by GADD45A silencing in the I/R injury rats. Mechanistically, GADD45A silencing reduced JNK/p38 MAPK expression but activated STAT3/VEGF expression. GADD45A silencing inhibited H/R‑induced viability reduction and apoptosis through MAPK signaling and suppressed angiogenesis via STAT3/VEGF in H/R‑induced CMECs. Overall, GADD45A ameliorated apoptosis and functional injury of CMECs via the JNK/p38 MAPK and STAT3/VEGF pathways." @default.
- W4308105901 created "2022-11-08" @default.
- W4308105901 creator A5006213514 @default.
- W4308105901 creator A5016018178 @default.
- W4308105901 creator A5043815269 @default.
- W4308105901 creator A5060335470 @default.
- W4308105901 creator A5064842058 @default.
- W4308105901 creator A5072225188 @default.
- W4308105901 creator A5082089233 @default.
- W4308105901 date "2022-11-03" @default.
- W4308105901 modified "2023-09-29" @default.
- W4308105901 title "Role of GADD45A in myocardial ischemia/reperfusion through mediation of the JNK/p38 MAPK and STAT3/VEGF pathways" @default.
- W4308105901 cites W1972229479 @default.
- W4308105901 cites W1983970295 @default.
- W4308105901 cites W1986553481 @default.
- W4308105901 cites W1996746173 @default.
- W4308105901 cites W2008872843 @default.
- W4308105901 cites W2010775796 @default.
- W4308105901 cites W2054838993 @default.
- W4308105901 cites W2055781716 @default.
- W4308105901 cites W2072772974 @default.
- W4308105901 cites W2107277218 @default.
- W4308105901 cites W2113162775 @default.
- W4308105901 cites W2145190952 @default.
- W4308105901 cites W2151767758 @default.
- W4308105901 cites W2158439676 @default.
- W4308105901 cites W2163405265 @default.
- W4308105901 cites W2171595458 @default.
- W4308105901 cites W2192080449 @default.
- W4308105901 cites W2276448528 @default.
- W4308105901 cites W2569535276 @default.
- W4308105901 cites W2605501320 @default.
- W4308105901 cites W2739449149 @default.
- W4308105901 cites W2790075228 @default.
- W4308105901 cites W2794459899 @default.
- W4308105901 cites W2810435886 @default.
- W4308105901 cites W29530928 @default.
- W4308105901 cites W2963547988 @default.
- W4308105901 cites W2965404232 @default.
- W4308105901 cites W2971590687 @default.
- W4308105901 cites W3014625906 @default.
- W4308105901 cites W3043857828 @default.
- W4308105901 cites W3092726210 @default.
- W4308105901 cites W3111133491 @default.
- W4308105901 doi "https://doi.org/10.3892/ijmm.2022.5200" @default.
- W4308105901 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36331027" @default.
- W4308105901 hasPublicationYear "2022" @default.
- W4308105901 type Work @default.
- W4308105901 citedByCount "2" @default.
- W4308105901 countsByYear W43081059012023 @default.
- W4308105901 crossrefType "journal-article" @default.
- W4308105901 hasAuthorship W4308105901A5006213514 @default.
- W4308105901 hasAuthorship W4308105901A5016018178 @default.
- W4308105901 hasAuthorship W4308105901A5043815269 @default.
- W4308105901 hasAuthorship W4308105901A5060335470 @default.
- W4308105901 hasAuthorship W4308105901A5064842058 @default.
- W4308105901 hasAuthorship W4308105901A5072225188 @default.
- W4308105901 hasAuthorship W4308105901A5082089233 @default.
- W4308105901 hasBestOaLocation W43081059011 @default.
- W4308105901 hasConcept C126322002 @default.
- W4308105901 hasConcept C184235292 @default.
- W4308105901 hasConcept C2780114680 @default.
- W4308105901 hasConcept C541997718 @default.
- W4308105901 hasConcept C57074206 @default.
- W4308105901 hasConcept C71924100 @default.
- W4308105901 hasConcept C86803240 @default.
- W4308105901 hasConcept C95444343 @default.
- W4308105901 hasConceptScore W4308105901C126322002 @default.
- W4308105901 hasConceptScore W4308105901C184235292 @default.
- W4308105901 hasConceptScore W4308105901C2780114680 @default.
- W4308105901 hasConceptScore W4308105901C541997718 @default.
- W4308105901 hasConceptScore W4308105901C57074206 @default.
- W4308105901 hasConceptScore W4308105901C71924100 @default.
- W4308105901 hasConceptScore W4308105901C86803240 @default.
- W4308105901 hasConceptScore W4308105901C95444343 @default.
- W4308105901 hasIssue "6" @default.
- W4308105901 hasLocation W43081059011 @default.
- W4308105901 hasLocation W43081059012 @default.
- W4308105901 hasLocation W43081059013 @default.
- W4308105901 hasOpenAccess W4308105901 @default.
- W4308105901 hasPrimaryLocation W43081059011 @default.
- W4308105901 hasRelatedWork W2014007142 @default.
- W4308105901 hasRelatedWork W2026123741 @default.
- W4308105901 hasRelatedWork W2029394706 @default.
- W4308105901 hasRelatedWork W2338316173 @default.
- W4308105901 hasRelatedWork W2357307238 @default.
- W4308105901 hasRelatedWork W2363406581 @default.
- W4308105901 hasRelatedWork W2373402090 @default.
- W4308105901 hasRelatedWork W2381991956 @default.
- W4308105901 hasRelatedWork W2394372752 @default.
- W4308105901 hasRelatedWork W3145217296 @default.
- W4308105901 hasVolume "50" @default.
- W4308105901 isParatext "false" @default.
- W4308105901 isRetracted "false" @default.
- W4308105901 workType "article" @default.