Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308108258> ?p ?o ?g. }
- W4308108258 endingPage "87.e14" @default.
- W4308108258 startingPage "70" @default.
- W4308108258 abstract "The evolution of established cancers is driven by selection of cells with enhanced fitness. Subclonal mutations in numerous epigenetic regulator genes are common across cancer types, yet their functional impact has been unclear. Here, we show that disruption of the epigenetic regulatory network increases the tolerance of cancer cells to unfavorable environments experienced within growing tumors by promoting the emergence of stress-resistant subpopulations. Disruption of epigenetic control does not promote selection of genetically defined subclones or favor a phenotypic switch in response to environmental changes. Instead, it prevents cells from mounting an efficient stress response via modulation of global transcriptional activity. This “transcriptional numbness” lowers the probability of cell death at early stages, increasing the chance of long-term adaptation at the population level. Our findings provide a mechanistic explanation for the widespread selection of subclonal epigenetic-related mutations in cancer and uncover phenotypic inertia as a cellular trait that drives subclone expansion." @default.
- W4308108258 created "2022-11-08" @default.
- W4308108258 creator A5005149415 @default.
- W4308108258 creator A5017774948 @default.
- W4308108258 creator A5019028054 @default.
- W4308108258 creator A5021804289 @default.
- W4308108258 creator A5035473922 @default.
- W4308108258 creator A5040208115 @default.
- W4308108258 creator A5050249920 @default.
- W4308108258 creator A5052723699 @default.
- W4308108258 creator A5052845258 @default.
- W4308108258 creator A5053466745 @default.
- W4308108258 creator A5062281323 @default.
- W4308108258 creator A5064623622 @default.
- W4308108258 creator A5074530517 @default.
- W4308108258 creator A5078706868 @default.
- W4308108258 creator A5083383225 @default.
- W4308108258 date "2023-01-01" @default.
- W4308108258 modified "2023-09-30" @default.
- W4308108258 title "Selective advantage of epigenetically disrupted cancer cells via phenotypic inertia" @default.
- W4308108258 cites W1548779692 @default.
- W4308108258 cites W1829845709 @default.
- W4308108258 cites W1883511910 @default.
- W4308108258 cites W1919257374 @default.
- W4308108258 cites W1922783847 @default.
- W4308108258 cites W1968657935 @default.
- W4308108258 cites W1978154786 @default.
- W4308108258 cites W1986092833 @default.
- W4308108258 cites W1987012261 @default.
- W4308108258 cites W1987971958 @default.
- W4308108258 cites W1992915563 @default.
- W4308108258 cites W1999574084 @default.
- W4308108258 cites W1999966784 @default.
- W4308108258 cites W2007725129 @default.
- W4308108258 cites W2009891171 @default.
- W4308108258 cites W2012674489 @default.
- W4308108258 cites W2025828346 @default.
- W4308108258 cites W2034852369 @default.
- W4308108258 cites W2035252444 @default.
- W4308108258 cites W2036897871 @default.
- W4308108258 cites W2044433401 @default.
- W4308108258 cites W2048122601 @default.
- W4308108258 cites W2055063781 @default.
- W4308108258 cites W2057463164 @default.
- W4308108258 cites W2063669247 @default.
- W4308108258 cites W2075251971 @default.
- W4308108258 cites W2077955829 @default.
- W4308108258 cites W2089923519 @default.
- W4308108258 cites W2103441770 @default.
- W4308108258 cites W2106578986 @default.
- W4308108258 cites W2108871359 @default.
- W4308108258 cites W2114031931 @default.
- W4308108258 cites W2114843025 @default.
- W4308108258 cites W2130410032 @default.
- W4308108258 cites W2146290346 @default.
- W4308108258 cites W2150457798 @default.
- W4308108258 cites W2154218976 @default.
- W4308108258 cites W2154871907 @default.
- W4308108258 cites W2169456326 @default.
- W4308108258 cites W2179438025 @default.
- W4308108258 cites W2179994591 @default.
- W4308108258 cites W2190545194 @default.
- W4308108258 cites W2286142055 @default.
- W4308108258 cites W2303653884 @default.
- W4308108258 cites W2321002580 @default.
- W4308108258 cites W2341539131 @default.
- W4308108258 cites W2490923018 @default.
- W4308108258 cites W2502703983 @default.
- W4308108258 cites W2586373162 @default.
- W4308108258 cites W2586629973 @default.
- W4308108258 cites W2595201960 @default.
- W4308108258 cites W2605897695 @default.
- W4308108258 cites W2609243345 @default.
- W4308108258 cites W2611387862 @default.
- W4308108258 cites W2613362156 @default.
- W4308108258 cites W2741363425 @default.
- W4308108258 cites W2750416916 @default.
- W4308108258 cites W2765242536 @default.
- W4308108258 cites W2767733991 @default.
- W4308108258 cites W2783416966 @default.
- W4308108258 cites W2785610956 @default.
- W4308108258 cites W2797282777 @default.
- W4308108258 cites W2885597648 @default.
- W4308108258 cites W2888546921 @default.
- W4308108258 cites W2897064819 @default.
- W4308108258 cites W2906180136 @default.
- W4308108258 cites W2914425504 @default.
- W4308108258 cites W2949177718 @default.
- W4308108258 cites W2950640427 @default.
- W4308108258 cites W2951158909 @default.
- W4308108258 cites W2952481429 @default.
- W4308108258 cites W3003159103 @default.
- W4308108258 cites W3005287223 @default.
- W4308108258 cites W3006379356 @default.
- W4308108258 cites W3006500278 @default.
- W4308108258 cites W3006653136 @default.
- W4308108258 cites W3015189679 @default.
- W4308108258 cites W3016379099 @default.