FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308117580> ?p ?o ?g. }

• W4308117580 endingPage "2395" @default.
• W4308117580 startingPage "2395" @default.
• W4308117580 abstract "Pulmonary dysbiosis may predispose people living with HIV (PLWH) to chronic lung disease. Herein, we assessed whether intrapulmonary HIV reservoir size and immune disruption are associated with reduced bacterial lung diversity in PLWH. Bacterial DNA was extracted and PCR-amplified from cell-free bronchoalveolar lavage (BAL) fluid from 28 PLWH and 9 HIV-negative controls. Amplicon sequence variant (ASV) relative abundances and taxonomic identities were analyzed using joint species distribution modeling. HIV-DNA was quantified from blood and pulmonary CD4+ T-cells using ultra-sensitive qPCR. Immunophenotyping of BAL T-cells was performed using flow cytometry. Lung microbiome diversity was lower in smokers than non-smokers and microbiome composition was more variable in PLWH than HIV-negative individuals. Frequencies of effector memory BAL CD4+ and CD8+ T-cells positively correlated with abundance of several bacterial families while frequencies of BAL activated CD4+ T-cells negatively correlated with abundance of most lung bacterial families. Higher HIV-DNA levels in blood, but not in BAL, as well as frequencies of senescent CD4+ T-cells were associated with reduced bacterial diversity. These findings suggest that HIV infection may weaken the relationship between the lung microbiome and smoking status. Viral reservoir and immune activation levels may impact the lung microbiome, predisposing PLWH to pulmonary comorbidities." @default.
• W4308117580 created "2022-11-08" @default.
• W4308117580 creator A5001226555 @default.
• W4308117580 creator A5001473679 @default.
• W4308117580 creator A5006440043 @default.
• W4308117580 creator A5011802278 @default.
• W4308117580 creator A5048796538 @default.
• W4308117580 creator A5055350869 @default.
• W4308117580 creator A5055757054 @default.
• W4308117580 creator A5068439238 @default.
• W4308117580 creator A5079312171 @default.
• W4308117580 date "2022-10-29" @default.
• W4308117580 modified "2023-10-03" @default.
• W4308117580 title "Interplay between the Lung Microbiome, Pulmonary Immunity and Viral Reservoirs in People Living with HIV under Antiretroviral Therapy" @default.
• W4308117580 cites W1616226146 @default.
• W4308117580 cites W1968051421 @default.
• W4308117580 cites W1979995401 @default.
• W4308117580 cites W1995671912 @default.
• W4308117580 cites W2011208161 @default.
• W4308117580 cites W2017037510 @default.
• W4308117580 cites W2034285706 @default.
• W4308117580 cites W2055962849 @default.
• W4308117580 cites W2061575742 @default.
• W4308117580 cites W2086026028 @default.
• W4308117580 cites W2091489722 @default.
• W4308117580 cites W2096288151 @default.
• W4308117580 cites W2105804574 @default.
• W4308117580 cites W2110558548 @default.
• W4308117580 cites W2111898748 @default.
• W4308117580 cites W2115015141 @default.
• W4308117580 cites W2124114936 @default.
• W4308117580 cites W2127366570 @default.
• W4308117580 cites W2150050151 @default.
• W4308117580 cites W2159497758 @default.
• W4308117580 cites W2161283816 @default.
• W4308117580 cites W2209314464 @default.
• W4308117580 cites W2272836689 @default.
• W4308117580 cites W2345165344 @default.
• W4308117580 cites W2345523549 @default.
• W4308117580 cites W2401404581 @default.
• W4308117580 cites W2431182801 @default.
• W4308117580 cites W2493480240 @default.
• W4308117580 cites W2520163688 @default.
• W4308117580 cites W2528396364 @default.
• W4308117580 cites W2555965680 @default.
• W4308117580 cites W2597532406 @default.
• W4308117580 cites W2748440687 @default.
• W4308117580 cites W2772260306 @default.
• W4308117580 cites W2797413896 @default.
• W4308117580 cites W2806389440 @default.
• W4308117580 cites W2883188821 @default.
• W4308117580 cites W2884218459 @default.
• W4308117580 cites W2886197410 @default.
• W4308117580 cites W2887176159 @default.
• W4308117580 cites W2889890740 @default.
• W4308117580 cites W2909615141 @default.
• W4308117580 cites W2917666184 @default.
• W4308117580 cites W2921046021 @default.
• W4308117580 cites W2951174125 @default.
• W4308117580 cites W2957204701 @default.
• W4308117580 cites W2978699383 @default.
• W4308117580 cites W3021158842 @default.
• W4308117580 cites W3034482583 @default.
• W4308117580 cites W3089099444 @default.
• W4308117580 cites W3124112500 @default.
• W4308117580 cites W3194348694 @default.
• W4308117580 cites W3200969974 @default.
• W4308117580 cites W4205415987 @default.
• W4308117580 cites W4206320827 @default.
• W4308117580 cites W4226089338 @default.
• W4308117580 cites W4226293772 @default.
• W4308117580 cites W4295745405 @default.
• W4308117580 doi "https://doi.org/10.3390/v14112395" @default.
• W4308117580 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36366495" @default.
• W4308117580 hasPublicationYear "2022" @default.
• W4308117580 type Work @default.
• W4308117580 citedByCount "1" @default.
• W4308117580 countsByYear W43081175802023 @default.
• W4308117580 crossrefType "journal-article" @default.
• W4308117580 hasAuthorship W4308117580A5001226555 @default.
• W4308117580 hasAuthorship W4308117580A5001473679 @default.
• W4308117580 hasAuthorship W4308117580A5006440043 @default.
• W4308117580 hasAuthorship W4308117580A5011802278 @default.
• W4308117580 hasAuthorship W4308117580A5048796538 @default.
• W4308117580 hasAuthorship W4308117580A5055350869 @default.
• W4308117580 hasAuthorship W4308117580A5055757054 @default.
• W4308117580 hasAuthorship W4308117580A5068439238 @default.
• W4308117580 hasAuthorship W4308117580A5079312171 @default.
• W4308117580 hasBestOaLocation W43081175801 @default.
• W4308117580 hasConcept C126322002 @default.
• W4308117580 hasConcept C143121216 @default.
• W4308117580 hasConcept C167672396 @default.
• W4308117580 hasConcept C196166836 @default.
• W4308117580 hasConcept C203014093 @default.
• W4308117580 hasConcept C2777714996 @default.
• W4308117580 hasConcept C2777961210 @default.
• W4308117580 hasConcept C2779341262 @default.
• W4308117580 hasConcept C54355233 @default.

• next