Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308121388> ?p ?o ?g. }
- W4308121388 endingPage "1812" @default.
- W4308121388 startingPage "1812" @default.
- W4308121388 abstract "Hepatic fibrosis (HF) is a major cause of liver-related disorders and together with cancer-associated fibroblasts can favor liver cancer development by modulating the tumor microenvironment. Advanced HF, characterized by an excess of extracellular matrix (ECM), is mediated by TGF- β1, that activates hepatic stellate cells (HSCs) and fibroblasts. A TGF-β1 receptor inhibitor, LY2157299 or Galunisertib (GLY), has shown promising results against chronic liver progression in animal models, and we show that it can be further improved by enhancing GLYs bioavailability through encapsulation in polymeric polygalacturonic-polyacrylic acid nanomicelles (GLY-NMs). GLY-NMs reduced HF in an in vivo rat model of liver fibrosis induced by intraperitoneal injection of CCl4 as shown by the morphological, biochemical, and molecular biology parameters of normal and fibrotic livers. Moreover, GLY-NM was able to induce recovery from HF better than free GLY. Indeed, the encapsulated drug reduces collagen deposition, hepatic stellate cells (HSCs) activation, prevents fatty degeneration and restores the correct lobular architecture of the liver as well as normalizes the serum parameters and expression of the genes involved in the onset of HF. In summary, GLY-NM improved the pharmacological activity of the free TGF- β1 inhibitor in the in vivo HF treatment and thus is a candidate as a novel therapeutic strategy." @default.
- W4308121388 created "2022-11-08" @default.
- W4308121388 creator A5008216039 @default.
- W4308121388 creator A5014075065 @default.
- W4308121388 creator A5014971889 @default.
- W4308121388 creator A5016813330 @default.
- W4308121388 creator A5034086427 @default.
- W4308121388 creator A5035055059 @default.
- W4308121388 creator A5050905987 @default.
- W4308121388 creator A5068700641 @default.
- W4308121388 creator A5069175811 @default.
- W4308121388 creator A5075457339 @default.
- W4308121388 creator A5076765975 @default.
- W4308121388 creator A5090718934 @default.
- W4308121388 date "2022-11-01" @default.
- W4308121388 modified "2023-10-16" @default.
- W4308121388 title "Therapeutic Effect of Polymeric Nanomicelles Formulation of LY2157299-Galunisertib on CCl4-Induced Liver Fibrosis in Rats" @default.
- W4308121388 cites W1844303090 @default.
- W4308121388 cites W1975088956 @default.
- W4308121388 cites W1981742209 @default.
- W4308121388 cites W2000369852 @default.
- W4308121388 cites W2064297038 @default.
- W4308121388 cites W2072277020 @default.
- W4308121388 cites W2079684286 @default.
- W4308121388 cites W2090468777 @default.
- W4308121388 cites W2099540110 @default.
- W4308121388 cites W2107144403 @default.
- W4308121388 cites W2114134841 @default.
- W4308121388 cites W2118435333 @default.
- W4308121388 cites W2136280424 @default.
- W4308121388 cites W2142988890 @default.
- W4308121388 cites W2151802718 @default.
- W4308121388 cites W2159373818 @default.
- W4308121388 cites W2167663690 @default.
- W4308121388 cites W2284013896 @default.
- W4308121388 cites W2296389641 @default.
- W4308121388 cites W2325596649 @default.
- W4308121388 cites W2411225414 @default.
- W4308121388 cites W2518660884 @default.
- W4308121388 cites W2562178994 @default.
- W4308121388 cites W2568294638 @default.
- W4308121388 cites W2587892042 @default.
- W4308121388 cites W2589123355 @default.
- W4308121388 cites W2735395814 @default.
- W4308121388 cites W2755540671 @default.
- W4308121388 cites W2770398624 @default.
- W4308121388 cites W2777017684 @default.
- W4308121388 cites W2785704704 @default.
- W4308121388 cites W2792387493 @default.
- W4308121388 cites W2800612868 @default.
- W4308121388 cites W2806380625 @default.
- W4308121388 cites W2807911134 @default.
- W4308121388 cites W2890324251 @default.
- W4308121388 cites W2890778790 @default.
- W4308121388 cites W2898066186 @default.
- W4308121388 cites W2900802770 @default.
- W4308121388 cites W2932470287 @default.
- W4308121388 cites W2960880851 @default.
- W4308121388 cites W2962221292 @default.
- W4308121388 cites W2975116744 @default.
- W4308121388 cites W2986691533 @default.
- W4308121388 cites W2995835183 @default.
- W4308121388 cites W3014599953 @default.
- W4308121388 cites W3033726977 @default.
- W4308121388 cites W3035713209 @default.
- W4308121388 cites W3081755994 @default.
- W4308121388 cites W3083451306 @default.
- W4308121388 cites W3093956657 @default.
- W4308121388 cites W3101391063 @default.
- W4308121388 cites W3103789003 @default.
- W4308121388 cites W3134477587 @default.
- W4308121388 cites W3146786433 @default.
- W4308121388 cites W3184845355 @default.
- W4308121388 cites W3205825978 @default.
- W4308121388 cites W4200255438 @default.
- W4308121388 cites W4285088739 @default.
- W4308121388 doi "https://doi.org/10.3390/jpm12111812" @default.
- W4308121388 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36579532" @default.
- W4308121388 hasPublicationYear "2022" @default.
- W4308121388 type Work @default.
- W4308121388 citedByCount "1" @default.
- W4308121388 countsByYear W43081213882023 @default.
- W4308121388 crossrefType "journal-article" @default.
- W4308121388 hasAuthorship W4308121388A5008216039 @default.
- W4308121388 hasAuthorship W4308121388A5014075065 @default.
- W4308121388 hasAuthorship W4308121388A5014971889 @default.
- W4308121388 hasAuthorship W4308121388A5016813330 @default.
- W4308121388 hasAuthorship W4308121388A5034086427 @default.
- W4308121388 hasAuthorship W4308121388A5035055059 @default.
- W4308121388 hasAuthorship W4308121388A5050905987 @default.
- W4308121388 hasAuthorship W4308121388A5068700641 @default.
- W4308121388 hasAuthorship W4308121388A5069175811 @default.
- W4308121388 hasAuthorship W4308121388A5075457339 @default.
- W4308121388 hasAuthorship W4308121388A5076765975 @default.
- W4308121388 hasAuthorship W4308121388A5090718934 @default.
- W4308121388 hasBestOaLocation W43081213881 @default.
- W4308121388 hasConcept C142724271 @default.
- W4308121388 hasConcept C150903083 @default.