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• W4308122664 endingPage "8329" @default.
• W4308122664 startingPage "8316" @default.
• W4308122664 abstract "Consolidation systemic therapy (ST) given after concurrent radiotherapy (RT) and ST (RT-ST) is frequently practiced in locally advanced inoperable nonsmall cell lung cancer (NSCLC). Little is known, however, about the fate of patients achieving different responses after concurrent phases of the treatment.we searched the English-language literature to identify full-length articles on phase II and Phase III clinical studies employing consolidation ST after initial concurrent RT-ST. We sought information about response evaluation after the concurrent phase and the outcome of these patient subgroups, the patterns of failure per response achieved after the concurrent phase as well as the outcome of these subgroups after the consolidation phase.Eighty-seven articles have been initially identified, of which 20 studies were excluded for various reasons, leaving, therefore, a total of 67 studies for our analysis. Response evaluation after the concurrent phase was performed in 36 (54%) studies but in only 14 (21%) response data were provided, while in 34 (51%) studies patients underwent a consolidation phase regardless of the response. No study provided any outcome (survivals, patterns of failure) as per response achieved after the concurrent phase.Information regarding the outcome of subgroups of patients achieving different responses after the concurrent phase and before the administration of the consolidation phase is still lacking. This may negatively affect the decision-making process as it remains unknown which patients may preferentially benefit from the consolidation of ST." @default.
• W4308122664 created "2022-11-08" @default.
• W4308122664 creator A5010728834 @default.
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• W4308122664 creator A5058609591 @default.
• W4308122664 creator A5067265895 @default.
• W4308122664 date "2022-10-31" @default.
• W4308122664 modified "2023-09-25" @default.
• W4308122664 title "Consolidation Systemic Therapy in Locally Advanced, Inoperable Nonsmall Cell Lung Cancer—How to Identify Patients Which Can Benefit from It?" @default.
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• W4308122664 doi "https://doi.org/10.3390/curroncol29110656" @default.
• W4308122664 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36354716" @default.
• W4308122664 hasPublicationYear "2022" @default.
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