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• W4308122968 abstract "Objective Maximal hyperemia is a key element of invasive physiological examination. The aim of this study was to investigate the efficacy and safety of intracoronary (IC) nicorandil in comparison with adenosine 5′-triphosphate (ATP) intravenous (i.v.) injection for fractional flow reserve (FFR) measurement in coronary artery lesions. Materials and methods In this study, 46 patients who had their FFR measured were enrolled, including 51 lesions. Hyperemia was induced by bolus 2 mg nicorandil and ATP (40 mg ATP + 36 ml saline, weight × 10 ml/h) for FFR measurement. The safety and efficacy of IC nicorandil were evaluated. Results The mean FFR values measured by nicorandil and ATP were 0.810 ± 0.013 and 0.799 ± 0.099, p &lt; 0.001, respectively. There was a strong correlation between FFR measured by nicorandil and ATP ( r = 0.983, R 2 = 0.966, FFR nicorandil = 0.937 × FFR ATP + 0.061). The rate of FFR ≤ 0.75 in the nicorandil and ATP groups was 31.37 vs. 35.29%, respectively ( p = 0.841), the consistency rate was 96.08%; the FFR ≤ 0.8 rate was 41.18 and 43.14%, respectively ( p = 0.674), and the consistency rate was 90.20%. In five lesions, the FFR value measured by nicorandil ranged between 0.79 and 0.82, indicating inconsistency according to FFR ≤ 0.8. The blood pressure changes caused by nicorandil and ATP were 12.96 ± 6.83 and 22.22 ± 11.44 mmHg ( p &lt; 0.001); the heart rate changes were 2.43 ± 1.31 and 6.52 ± 2.87 beats/min, respectively ( p &lt; 0.001); and the PR interval changes were 6.0 (1.0–11.0) and 9.0 (2.0–19.0) ms, respectively ( p &lt; 0.001). Visual analog scale (VAS) scores in the nicorandil group were all in the range 0–2, while in the ATP group were mostly in the range of 3–5. Conclusion Intracoronary bolus of nicorandil (2 mg) infusion induces stable hyperemia, and it could be considered as an alternative drug to ATP for FFR measurement with a lower side effect profile in most patients." @default.
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• W4308122968 date "2022-11-02" @default.
• W4308122968 modified "2023-10-15" @default.
• W4308122968 title "Intracoronary nicorandil induced hyperemia for physiological assessments in the coronary artery lesions" @default.
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• W4308122968 doi "https://doi.org/10.3389/fcvm.2022.1023641" @default.
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