FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308123926> ?p ?o ?g. }

• W4308123926 abstract "Hepatocellular carcinoma (HCC) is the most prevalent pathological type of liver cancer worldwide with high mortality and poor prognosis. N6-methyladenosine (m6A) can modify RNAs such as mRNA, lncRNA, miRNA, and tRNA, thereby playing a critical role in the pathogenesis of HCC. However, the role of m6A-associated small nuclear RNA (snRNA) in the prognostic value and immunotherapeutic response in HCC remains unclear.In this study, snRNA expression data, gene mutation data, and clinical data of HCC patients were acquired from The Cancer Genome Atlas (TCGA) database. We used the least absolute shrinkage and selection operator (LASSO) Cox regression analysis to identify significant prognostic m6A-associated snRNAs, and then developed a multivariate Cox model based on the selected snRNAs. HCC patients were split into low- and high-risk groups based on the median risk score. We subsequently performed Kaplan-Meier curve analysis to estimate overall survival (OS) by clinicopathological characteristics and tumor mutational burden (TMB) status in low- and high-risk HCC patients. Finally, we compared the immunotherapeutic response as represented by tumor immune dysfunction and exclusion (TIDE) scores between the two risk groups.Eight m6A-associated snRNAs were selected as independent predictors to develop the risk model. Our results revealed that the OS of HCC patients in the high-risk group was significantly worse than that in the low-risk group on clinicopathologic characteristics, including age (≤65 years and >65 years), gender (male), grade (G I-II and G III-IV) and TNM staging (Stage I-II and Stage III-IV). In addition, the OS of low-TMB and low-risk group was longer than that of high-TMB and high-risk group. The TIDE score indicated that HCC patients in the high-risk group were more susceptible to immunotherapy.Our study suggests that m6A-associated snRNAs may be useful biomarkers for the prognosis of HCC and that m6A-associated snRNA models can predict the effect of immunotherapy in HCC patients." @default.
• W4308123926 created "2022-11-08" @default.
• W4308123926 creator A5011991827 @default.
• W4308123926 creator A5017140872 @default.
• W4308123926 creator A5037131488 @default.
• W4308123926 creator A5064466730 @default.
• W4308123926 creator A5073070877 @default.
• W4308123926 creator A5075596275 @default.
• W4308123926 creator A5082941373 @default.
• W4308123926 date "2022-11-02" @default.
• W4308123926 modified "2023-10-01" @default.
• W4308123926 title "Implications of m6A-associated snRNAs in the prognosis and immunotherapeutic responses of hepatocellular carcinoma" @default.
• W4308123926 cites W1970633843 @default.
• W4308123926 cites W1975364025 @default.
• W4308123926 cites W1987109078 @default.
• W4308123926 cites W2031709894 @default.
• W4308123926 cites W2033821807 @default.
• W4308123926 cites W2064751862 @default.
• W4308123926 cites W2140995557 @default.
• W4308123926 cites W2165605869 @default.
• W4308123926 cites W2616848081 @default.
• W4308123926 cites W2769856951 @default.
• W4308123926 cites W2770747479 @default.
• W4308123926 cites W2883872430 @default.
• W4308123926 cites W2886498337 @default.
• W4308123926 cites W2891713480 @default.
• W4308123926 cites W2912048746 @default.
• W4308123926 cites W2972600793 @default.
• W4308123926 cites W2977528366 @default.
• W4308123926 cites W2990161111 @default.
• W4308123926 cites W3014385623 @default.
• W4308123926 cites W3019133351 @default.
• W4308123926 cites W3020963897 @default.
• W4308123926 cites W3027304397 @default.
• W4308123926 cites W3043883227 @default.
• W4308123926 cites W3044553904 @default.
• W4308123926 cites W3081143873 @default.
• W4308123926 cites W3086576215 @default.
• W4308123926 cites W3096121935 @default.
• W4308123926 cites W3128646645 @default.
• W4308123926 cites W3133117790 @default.
• W4308123926 cites W3133536578 @default.
• W4308123926 cites W3133844279 @default.
• W4308123926 cites W3165561687 @default.
• W4308123926 cites W3193242816 @default.
• W4308123926 cites W3204680924 @default.
• W4308123926 cites W4200066640 @default.
• W4308123926 cites W4205255097 @default.
• W4308123926 cites W4206368060 @default.
• W4308123926 cites W4206961595 @default.
• W4308123926 cites W4210774372 @default.
• W4308123926 cites W4211182482 @default.
• W4308123926 cites W4212895371 @default.
• W4308123926 cites W4220886525 @default.
• W4308123926 cites W4223421663 @default.
• W4308123926 cites W4225427531 @default.
• W4308123926 cites W4232342538 @default.
• W4308123926 doi "https://doi.org/10.3389/fimmu.2022.1001506" @default.
• W4308123926 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36405741" @default.
• W4308123926 hasPublicationYear "2022" @default.
• W4308123926 type Work @default.
• W4308123926 citedByCount "2" @default.
• W4308123926 countsByYear W43081239262023 @default.
• W4308123926 crossrefType "journal-article" @default.
• W4308123926 hasAuthorship W4308123926A5011991827 @default.
• W4308123926 hasAuthorship W4308123926A5017140872 @default.
• W4308123926 hasAuthorship W4308123926A5037131488 @default.
• W4308123926 hasAuthorship W4308123926A5064466730 @default.
• W4308123926 hasAuthorship W4308123926A5073070877 @default.
• W4308123926 hasAuthorship W4308123926A5075596275 @default.
• W4308123926 hasAuthorship W4308123926A5082941373 @default.
• W4308123926 hasBestOaLocation W43081239261 @default.
• W4308123926 hasConcept C121608353 @default.
• W4308123926 hasConcept C126322002 @default.
• W4308123926 hasConcept C143998085 @default.
• W4308123926 hasConcept C146357865 @default.
• W4308123926 hasConcept C151730666 @default.
• W4308123926 hasConcept C2778019345 @default.
• W4308123926 hasConcept C50382708 @default.
• W4308123926 hasConcept C71924100 @default.
• W4308123926 hasConcept C86803240 @default.
• W4308123926 hasConceptScore W4308123926C121608353 @default.
• W4308123926 hasConceptScore W4308123926C126322002 @default.
• W4308123926 hasConceptScore W4308123926C143998085 @default.
• W4308123926 hasConceptScore W4308123926C146357865 @default.
• W4308123926 hasConceptScore W4308123926C151730666 @default.
• W4308123926 hasConceptScore W4308123926C2778019345 @default.
• W4308123926 hasConceptScore W4308123926C50382708 @default.
• W4308123926 hasConceptScore W4308123926C71924100 @default.
• W4308123926 hasConceptScore W4308123926C86803240 @default.
• W4308123926 hasLocation W43081239261 @default.
• W4308123926 hasLocation W43081239262 @default.
• W4308123926 hasLocation W43081239263 @default.
• W4308123926 hasOpenAccess W4308123926 @default.
• W4308123926 hasPrimaryLocation W43081239261 @default.
• W4308123926 hasRelatedWork W1974713739 @default.
• W4308123926 hasRelatedWork W2045692320 @default.
• W4308123926 hasRelatedWork W2212763461 @default.
• W4308123926 hasRelatedWork W2295614744 @default.
• W4308123926 hasRelatedWork W2356105190 @default.

• next