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- W4308125788 abstract "Cofactors are crucial for the biosynthesis of natural compounds, and cofactor engineering is a useful strategy for enzyme optimization due to its potential to enhance enzyme efficiency. Secoisolariciresinol dehydrogenase (SIRD) was reported to convert secoisolariciresinol into matairesinol in an NAD + -dependent reaction. Here, a SIRD designated as Ii SIRD2 identified from Isatis indigotica was found to utilize NADP + as the cofactor. To explore the structural basis for this unique cofactor preference, model-based structural analysis was carried out, and it was postulated that a variation at the GXGGXG glycine-rich motif of Ii SIRD2 alters its cofactor preference. This study paves way for future investigations on SIRD cofactor specificity and cofactor engineering to improve SIRD’s catalytic efficiency." @default.
- W4308125788 created "2022-11-08" @default.
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- W4308125788 date "2022-11-02" @default.
- W4308125788 modified "2023-09-26" @default.
- W4308125788 title "Identification and investigation of a novel NADP+-dependent secoisolariciresinol dehydrogenase from Isatis indigotica" @default.
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- W4308125788 doi "https://doi.org/10.3389/fpls.2022.1035121" @default.
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