Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308126006> ?p ?o ?g. }
- W4308126006 abstract "Lung cancer is a disease with remarkable heterogeneity. A deep understanding of the tumor microenvironment (TME) offers potential therapeutic strategies against this malignant disease. More and more attention has been paid to the roles of macrophages in the TME. This article briefly summarizes the origin of macrophages, the mutual regulation between anti-tumoral immunity and pro-tumoral statuses derived from macrophage polarization, and the therapeutic opportunities targeting alternately activated macrophages (AAM)-type macrophage polarization. Among them, cellular components including T cells, as well as acellular components represented by IL-4 and IL-13 are key regulators driving the polarization of AAM macrophages. Novel treatments targeting macrophage-associated mechanisms are mainly divided into small molecule inhibitors, monoclonal antibodies, and other therapies to re-acclimate AMM macrophages. Finally, we paid special attention to an immunosuppressive subgroup of macrophages with T cell immunoglobulin and mucin domain-3 (TIM-3) expression. Based on cellular interactions with cancer cells, TIM3+ macrophages facilitate the proliferation and progression of cancer cells, yet this process exposes targets blocking the ligand-receptor recognition. To sum up, this is a systematic review on the mechanism of tumor-associated macrophages (TAM) polarization, therapeutic strategies and the biological functions of Tim-3 positive macrophages that aims to provide new insights into the pathogenesis and treatment of lung cancer." @default.
- W4308126006 created "2022-11-08" @default.
- W4308126006 creator A5032995423 @default.
- W4308126006 creator A5046941806 @default.
- W4308126006 creator A5054498997 @default.
- W4308126006 creator A5075493474 @default.
- W4308126006 creator A5078468431 @default.
- W4308126006 creator A5086762809 @default.
- W4308126006 date "2022-11-02" @default.
- W4308126006 modified "2023-10-07" @default.
- W4308126006 title "Cutting edges and therapeutic opportunities on tumor-associated macrophages in lung cancer" @default.
- W4308126006 cites W1538049069 @default.
- W4308126006 cites W1560466618 @default.
- W4308126006 cites W1663505974 @default.
- W4308126006 cites W1881610795 @default.
- W4308126006 cites W1902699342 @default.
- W4308126006 cites W1910012553 @default.
- W4308126006 cites W1974608253 @default.
- W4308126006 cites W1977067868 @default.
- W4308126006 cites W1978183014 @default.
- W4308126006 cites W1980485314 @default.
- W4308126006 cites W1983484216 @default.
- W4308126006 cites W1995299599 @default.
- W4308126006 cites W1997731331 @default.
- W4308126006 cites W1999419270 @default.
- W4308126006 cites W2000217512 @default.
- W4308126006 cites W2000272838 @default.
- W4308126006 cites W2001713238 @default.
- W4308126006 cites W2001717792 @default.
- W4308126006 cites W2008065206 @default.
- W4308126006 cites W2010876644 @default.
- W4308126006 cites W2011515061 @default.
- W4308126006 cites W2013177587 @default.
- W4308126006 cites W2016209020 @default.
- W4308126006 cites W2019279852 @default.
- W4308126006 cites W2023164440 @default.
- W4308126006 cites W2028292569 @default.
- W4308126006 cites W2031603575 @default.
- W4308126006 cites W2033278321 @default.
- W4308126006 cites W2040272267 @default.
- W4308126006 cites W2042354033 @default.
- W4308126006 cites W2043044540 @default.
- W4308126006 cites W2054841768 @default.
- W4308126006 cites W2055243308 @default.
- W4308126006 cites W2058648826 @default.
- W4308126006 cites W2060672294 @default.
- W4308126006 cites W2065210647 @default.
- W4308126006 cites W2065635612 @default.
- W4308126006 cites W2065869173 @default.
- W4308126006 cites W2066671159 @default.
- W4308126006 cites W2068756420 @default.
- W4308126006 cites W2068793888 @default.
- W4308126006 cites W2069995717 @default.
- W4308126006 cites W2071959986 @default.
- W4308126006 cites W2076743146 @default.
- W4308126006 cites W2085193829 @default.
- W4308126006 cites W2092075198 @default.
- W4308126006 cites W2098888044 @default.
- W4308126006 cites W2100820895 @default.
- W4308126006 cites W2103746815 @default.
- W4308126006 cites W2103950437 @default.
- W4308126006 cites W2106027870 @default.
- W4308126006 cites W2109593516 @default.
- W4308126006 cites W2112101426 @default.
- W4308126006 cites W2116554142 @default.
- W4308126006 cites W2117692326 @default.
- W4308126006 cites W2118416525 @default.
- W4308126006 cites W2119523362 @default.
- W4308126006 cites W2123640179 @default.
- W4308126006 cites W2128856207 @default.
- W4308126006 cites W2130670290 @default.
- W4308126006 cites W2134653497 @default.
- W4308126006 cites W2138694950 @default.
- W4308126006 cites W2140531769 @default.
- W4308126006 cites W2142530756 @default.
- W4308126006 cites W2145024411 @default.
- W4308126006 cites W2145857936 @default.
- W4308126006 cites W2148148250 @default.
- W4308126006 cites W2148667640 @default.
- W4308126006 cites W2148898943 @default.
- W4308126006 cites W2149545956 @default.
- W4308126006 cites W2150678612 @default.
- W4308126006 cites W2153406260 @default.
- W4308126006 cites W2154942206 @default.
- W4308126006 cites W2155906739 @default.
- W4308126006 cites W2156915900 @default.
- W4308126006 cites W2157485001 @default.
- W4308126006 cites W2158809810 @default.
- W4308126006 cites W2161074777 @default.
- W4308126006 cites W2161091841 @default.
- W4308126006 cites W2162085901 @default.
- W4308126006 cites W2163486647 @default.
- W4308126006 cites W2165836181 @default.
- W4308126006 cites W2167485774 @default.
- W4308126006 cites W2234115940 @default.
- W4308126006 cites W2261243847 @default.
- W4308126006 cites W2285436607 @default.
- W4308126006 cites W2314057593 @default.
- W4308126006 cites W2508069933 @default.
- W4308126006 cites W2513641194 @default.