FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308126023> ?p ?o ?g. }

• W4308126023 abstract "Human coronaviruses (HCoVs) HCoV-NL63, HCoV-229E, HCoV-HKU1 and HCoV-OC43 have been circulated in the human population worldwide, and they are associated with a broad range of respiratory diseases with varying severity. However, there are neither effective therapeutic drugs nor licensed vaccines available for the treatment and prevention of infections by the four HCoVs. In this study, we collected nasopharyngeal aspirates of children hospitalized for respiratory tract infection in China during 2014-2018 and conducted next-generation sequencing. Sequences of four HCoVs were then selected for an in-depth analysis. Genome sequences of 2 HCoV-NL63, 8 HCoV-229E, 2 HCoV-HKU1, and 6 HCoV-OC43 were obtained. Based on the full-length S gene, a strong temporal signal was found in HCoV-229E and the molecular evolutionary rate was 6 × 10-4 substitutions/site/year. Based on the maximum-likelihood (ML) phylogenetic tree of complete S gene, we designated H78 as a new sub-genotype C2 of HCoV-HKU1, and the obtained P43 sequence was grouped into the reported novel genotype K of HCoV-OC43 circulating in Guangzhou, China. Based on the complete genome, potential recombination events were found to occur as two phenomena, namely intraspecies and interspecies. Moreover, we observed two amino acid substitutions in the S1 subunit of obtained HCoV-NL63 (G534V) and HCoV-HKU1 (H512R), while residues 534 and 512 are important for the binding of angiotensin-converting enzyme 2 and neutralizing antibodies, respectively. Our findings might provide a clue for the molecular evolution of the four HCoVs and help in the early diagnosis, treatment and prevention of broad-spectrum HCoV infection." @default.
• W4308126023 created "2022-11-08" @default.
• W4308126023 creator A5002066834 @default.
• W4308126023 creator A5012389819 @default.
• W4308126023 creator A5018323072 @default.
• W4308126023 creator A5031980913 @default.
• W4308126023 creator A5035880695 @default.
• W4308126023 creator A5042967060 @default.
• W4308126023 creator A5055324098 @default.
• W4308126023 creator A5063863355 @default.
• W4308126023 creator A5088141052 @default.
• W4308126023 creator A5088174174 @default.
• W4308126023 date "2022-11-02" @default.
• W4308126023 modified "2023-09-30" @default.
• W4308126023 title "Molecular evolution of human coronavirus-NL63, -229E, -HKU1 and -OC43 in hospitalized children in China" @default.
• W4308126023 cites W2011374678 @default.
• W4308126023 cites W2043121724 @default.
• W4308126023 cites W2079074163 @default.
• W4308126023 cites W2098998255 @default.
• W4308126023 cites W2102109092 @default.
• W4308126023 cites W2113005072 @default.
• W4308126023 cites W2115897082 @default.
• W4308126023 cites W2118048521 @default.
• W4308126023 cites W2143901293 @default.
• W4308126023 cites W2152207030 @default.
• W4308126023 cites W2230587089 @default.
• W4308126023 cites W2255243349 @default.
• W4308126023 cites W2256544155 @default.
• W4308126023 cites W2306794997 @default.
• W4308126023 cites W2316155243 @default.
• W4308126023 cites W2332629841 @default.
• W4308126023 cites W2336400828 @default.
• W4308126023 cites W2491014331 @default.
• W4308126023 cites W2576706040 @default.
• W4308126023 cites W2620083990 @default.
• W4308126023 cites W2773680311 @default.
• W4308126023 cites W2804822363 @default.
• W4308126023 cites W2940431758 @default.
• W4308126023 cites W2953275535 @default.
• W4308126023 cites W3001897055 @default.
• W4308126023 cites W3004141569 @default.
• W4308126023 cites W3010377921 @default.
• W4308126023 cites W3015294015 @default.
• W4308126023 cites W3034883465 @default.
• W4308126023 cites W3037916911 @default.
• W4308126023 cites W3041924266 @default.
• W4308126023 cites W3045941675 @default.
• W4308126023 cites W3111125496 @default.
• W4308126023 cites W3128993591 @default.
• W4308126023 cites W3144378969 @default.
• W4308126023 cites W3185675133 @default.
• W4308126023 cites W3198439575 @default.
• W4308126023 cites W4200009748 @default.
• W4308126023 cites W4225907029 @default.
• W4308126023 doi "https://doi.org/10.3389/fmicb.2022.1023847" @default.
• W4308126023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36406425" @default.
• W4308126023 hasPublicationYear "2022" @default.
• W4308126023 type Work @default.
• W4308126023 citedByCount "6" @default.
• W4308126023 countsByYear W43081260232023 @default.
• W4308126023 crossrefType "journal-article" @default.
• W4308126023 hasAuthorship W4308126023A5002066834 @default.
• W4308126023 hasAuthorship W4308126023A5012389819 @default.
• W4308126023 hasAuthorship W4308126023A5018323072 @default.
• W4308126023 hasAuthorship W4308126023A5031980913 @default.
• W4308126023 hasAuthorship W4308126023A5035880695 @default.
• W4308126023 hasAuthorship W4308126023A5042967060 @default.
• W4308126023 hasAuthorship W4308126023A5055324098 @default.
• W4308126023 hasAuthorship W4308126023A5063863355 @default.
• W4308126023 hasAuthorship W4308126023A5088141052 @default.
• W4308126023 hasAuthorship W4308126023A5088174174 @default.
• W4308126023 hasBestOaLocation W43081260231 @default.
• W4308126023 hasConcept C104317684 @default.
• W4308126023 hasConcept C135763542 @default.
• W4308126023 hasConcept C141231307 @default.
• W4308126023 hasConcept C159047783 @default.
• W4308126023 hasConcept C193252679 @default.
• W4308126023 hasConcept C54355233 @default.
• W4308126023 hasConcept C86803240 @default.
• W4308126023 hasConceptScore W4308126023C104317684 @default.
• W4308126023 hasConceptScore W4308126023C135763542 @default.
• W4308126023 hasConceptScore W4308126023C141231307 @default.
• W4308126023 hasConceptScore W4308126023C159047783 @default.
• W4308126023 hasConceptScore W4308126023C193252679 @default.
• W4308126023 hasConceptScore W4308126023C54355233 @default.
• W4308126023 hasConceptScore W4308126023C86803240 @default.
• W4308126023 hasFunder F4320337504 @default.
• W4308126023 hasLocation W43081260231 @default.
• W4308126023 hasLocation W43081260232 @default.
• W4308126023 hasLocation W43081260233 @default.
• W4308126023 hasLocation W43081260234 @default.
• W4308126023 hasOpenAccess W4308126023 @default.
• W4308126023 hasPrimaryLocation W43081260231 @default.
• W4308126023 hasRelatedWork W1993951481 @default.
• W4308126023 hasRelatedWork W2002128513 @default.
• W4308126023 hasRelatedWork W2068084996 @default.
• W4308126023 hasRelatedWork W2069184423 @default.
• W4308126023 hasRelatedWork W2097383755 @default.
• W4308126023 hasRelatedWork W2141682026 @default.
• W4308126023 hasRelatedWork W2177037579 @default.

• next