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- W4308128276 endingPage "6431" @default.
- W4308128276 startingPage "6431" @default.
- W4308128276 abstract "Mitochondria are important organelles whose primary role is generating energy through the oxidative phosphorylation (OXPHOS) system. Cardiomyopathy, a common clinical disorder, is frequently associated with pathogenic mutations in nuclear and mitochondrial genes. To date, a growing number of nuclear gene mutations have been linked with cardiomyopathy; however, knowledge about mitochondrial tRNAs (mt-tRNAs) mutations in this disease remain inadequately understood. In fact, defects in mt-tRNA metabolism caused by pathogenic mutations may influence the functioning of the OXPHOS complexes, thereby impairing mitochondrial translation, which plays a critical role in the predisposition of this disease. In this review, we summarize some basic knowledge about tRNA biology, including its structure and function relations, modification, CCA-addition, and tRNA import into mitochondria. Furthermore, a variety of molecular mechanisms underlying tRNA mutations that cause mitochondrial dysfunctions are also discussed in this article." @default.
- W4308128276 created "2022-11-08" @default.
- W4308128276 creator A5033280910 @default.
- W4308128276 creator A5077106342 @default.
- W4308128276 creator A5082947829 @default.
- W4308128276 date "2022-10-30" @default.
- W4308128276 modified "2023-09-29" @default.
- W4308128276 title "Mitochondrial Cardiomyopathy: The Roles of mt-tRNA Mutations" @default.
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