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- W4308128827 endingPage "3447" @default.
- W4308128827 startingPage "3447" @default.
- W4308128827 abstract "Pituitary gonadotropins directly govern ovarian functions, which are in turn regulated by the ovarian steroid hormones. The precise interplay of gonadotropins and steroid hormones is critical for follicle growth and differentiation. Furthermore, autophagy regulates ovarian follicle differentiation. However, how the high-fat-high fructose (HFD-HF) diet regulates gonadotropins and facilitates autophagy-mediated follicular differentiation in the ovary is obscure. We fed prepubertal rats (PND 25) an HFD-HF diet until PND 90. The results showed diminished adenohypophyseal GnRHR, PR, and aromatase expression, whereas AR, ERα, PRLR, and inhibin were augmented, resulting in gonadotropins decline. Interestingly, autophagy biomarkers, Beclin-1, ATG5, ATG12, LC3-II, and LAMP1 were reduced but SQSTM1/p62 was augmented in the ovaries of HFD-HF-fed rats, causing autolysosome to aggregation. The diet altered T, E2, P4, PRL, and their receptors status in the ovary, disturbed estrous cyclicity, and delayed vaginal opening. Ovarian histomorphology exhibited numerous cystic and atretic follicles, along with disturbed follicular maturation and ovulation. Moreover, the reduction of FSHR; steroidogenic proteins; receptor proteins AR, ERβ, PR; and signaling proteins Wnt2 and β-catenin was also noticed in the ovary, whereas PRLR, inhibin, and pGSK3β were augmented. In conclusion, exposure to a prepubertal HFD-HF diet leads to hypogonadotropism and the autophagy-mediated defective differentiation of ovarian follicles, abating fertility in adult rats." @default.
- W4308128827 created "2022-11-08" @default.
- W4308128827 creator A5009256221 @default.
- W4308128827 creator A5039052585 @default.
- W4308128827 creator A5052025540 @default.
- W4308128827 creator A5055342332 @default.
- W4308128827 date "2022-10-31" @default.
- W4308128827 modified "2023-10-01" @default.
- W4308128827 title "High Fat-High Fructose Diet Elicits Hypogonadotropism Culminating in Autophagy-Mediated Defective Differentiation of Ovarian Follicles" @default.
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- W4308128827 doi "https://doi.org/10.3390/cells11213447" @default.
- W4308128827 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36359843" @default.
- W4308128827 hasPublicationYear "2022" @default.