Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308128836> ?p ?o ?g. }
- W4308128836 endingPage "3449" @default.
- W4308128836 startingPage "3449" @default.
- W4308128836 abstract "(1) Background: statins have been considered an attractive class of drugs in the pharmacological setting of COVID-19 due to their pleiotropic properties and their use correlates with decreased mortality in hospitalized COVID-19 patients. Furthermore, it is well known that statins, which block the mevalonate pathway, affect γδ T lymphocyte activation. As γδ T cells participate in the inflammatory process of COVID-19, we have investigated the therapeutical potential of statins as a tool to inhibit γδ T cell pro-inflammatory activities; (2) Methods: we harvested peripheral blood mononuclear cells (PBMCs) from COVID-19 patients with mild clinical manifestations, COVID-19 recovered patients, and healthy controls. We performed ex vivo flow cytometry analysis to study γδ T cell frequency, phenotype, and exhaustion status. PBMCs were treated with Atorvastatin followed by non-specific and specific stimulation, to evaluate the expression of pro-inflammatory cytokines; (3) Results: COVID-19 patients had a lower frequency of circulating Vδ2+ T lymphocytes but showed a pronounced pro-inflammatory profile, which was inhibited by in vitro treatment with statins; (4) Conclusions: the in vitro capacity of statins to inhibit Vδ2+ T lymphocytes in COVID-19 patients highlights a new potential biological function of these drugs and supports their therapeutical use in these patients." @default.
- W4308128836 created "2022-11-08" @default.
- W4308128836 creator A5004648556 @default.
- W4308128836 creator A5010991352 @default.
- W4308128836 creator A5028162881 @default.
- W4308128836 creator A5038857342 @default.
- W4308128836 creator A5041560313 @default.
- W4308128836 creator A5051995497 @default.
- W4308128836 creator A5052785938 @default.
- W4308128836 creator A5080411648 @default.
- W4308128836 date "2022-10-31" @default.
- W4308128836 modified "2023-09-30" @default.
- W4308128836 title "Phenotypical and Functional Alteration of γδ T Lymphocytes in COVID-19 Patients: Reversal by Statins" @default.
- W4308128836 cites W1550875496 @default.
- W4308128836 cites W1594525188 @default.
- W4308128836 cites W1717893338 @default.
- W4308128836 cites W1981174960 @default.
- W4308128836 cites W1985206926 @default.
- W4308128836 cites W1987612522 @default.
- W4308128836 cites W1990438214 @default.
- W4308128836 cites W1993904515 @default.
- W4308128836 cites W2009470002 @default.
- W4308128836 cites W2032841359 @default.
- W4308128836 cites W2046651079 @default.
- W4308128836 cites W2079821054 @default.
- W4308128836 cites W2092059547 @default.
- W4308128836 cites W2093135927 @default.
- W4308128836 cites W2095956260 @default.
- W4308128836 cites W2101844022 @default.
- W4308128836 cites W2104585349 @default.
- W4308128836 cites W2106410542 @default.
- W4308128836 cites W2131894979 @default.
- W4308128836 cites W2134497001 @default.
- W4308128836 cites W2137983259 @default.
- W4308128836 cites W2143835519 @default.
- W4308128836 cites W2156519908 @default.
- W4308128836 cites W2170263258 @default.
- W4308128836 cites W2222665820 @default.
- W4308128836 cites W2345375613 @default.
- W4308128836 cites W2537610262 @default.
- W4308128836 cites W2570787279 @default.
- W4308128836 cites W2586240034 @default.
- W4308128836 cites W2755703997 @default.
- W4308128836 cites W2761411245 @default.
- W4308128836 cites W2766906828 @default.
- W4308128836 cites W2773191002 @default.
- W4308128836 cites W2911162287 @default.
- W4308128836 cites W2990093433 @default.
- W4308128836 cites W3009859788 @default.
- W4308128836 cites W3011761677 @default.
- W4308128836 cites W3012421327 @default.
- W4308128836 cites W3014003872 @default.
- W4308128836 cites W3014808081 @default.
- W4308128836 cites W3019360767 @default.
- W4308128836 cites W3023838751 @default.
- W4308128836 cites W3024483427 @default.
- W4308128836 cites W3028395950 @default.
- W4308128836 cites W3032808434 @default.
- W4308128836 cites W3034818843 @default.
- W4308128836 cites W3035860713 @default.
- W4308128836 cites W3035931817 @default.
- W4308128836 cites W3036683212 @default.
- W4308128836 cites W3037373536 @default.
- W4308128836 cites W3039572263 @default.
- W4308128836 cites W3041494167 @default.
- W4308128836 cites W3041886785 @default.
- W4308128836 cites W3048268189 @default.
- W4308128836 cites W3049325061 @default.
- W4308128836 cites W3080393158 @default.
- W4308128836 cites W3080527067 @default.
- W4308128836 cites W3081770779 @default.
- W4308128836 cites W3082341874 @default.
- W4308128836 cites W3085824346 @default.
- W4308128836 cites W3089169829 @default.
- W4308128836 cites W3092817099 @default.
- W4308128836 cites W3110730557 @default.
- W4308128836 cites W3112470441 @default.
- W4308128836 cites W3113491368 @default.
- W4308128836 cites W3119953938 @default.
- W4308128836 cites W3126500637 @default.
- W4308128836 cites W3132610875 @default.
- W4308128836 cites W3132811058 @default.
- W4308128836 cites W3132895255 @default.
- W4308128836 cites W3135727443 @default.
- W4308128836 cites W3148409844 @default.
- W4308128836 cites W3154294714 @default.
- W4308128836 cites W3164929511 @default.
- W4308128836 cites W3171244696 @default.
- W4308128836 cites W3193439971 @default.
- W4308128836 cites W3193480463 @default.
- W4308128836 cites W3199984496 @default.
- W4308128836 cites W3208066292 @default.
- W4308128836 cites W3208089728 @default.
- W4308128836 cites W3208453889 @default.
- W4308128836 cites W3210027344 @default.
- W4308128836 cites W4283167619 @default.
- W4308128836 doi "https://doi.org/10.3390/cells11213449" @default.
- W4308128836 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36359845" @default.